Abstract
Although prostaglandin production has been associated with neoplasia, a causal relationship has never been demonstrated. Most mammalian cells have the enzymes that metabolize arachidonic acid, hut the capacity to generate the thromboxanes, prostacyclins, the various prostaglandins, mono- and dihydroxyfatty acids and the peptide-containing leukotrienes from endogenous substrate varies among the cells (1–7). The relative levels of these arachidonic acid metabolites produced endogenously (the cell’s arachidonic acid metabolite profile) also can vary with the cell’s state of differentiation and nutritional history. Examples of how 1) genetic specification (although it should be realized that postreplicative events also are important), 2) differentiation, and 3) nutrition can affect these profiles are given in Table 1, and Fig. 1 and Fig. 2, respectively.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Levine L, Alam A: Deacylation of cellular lipids and arachidonid acid metabolism. Prog in Lipid Res (20): 81–88, 1982.
Levine L, Moskowitz, MA: Alpha- and beta-adrenergic stimulation of arachidonic acid metabolism by cells in culture. Proc Natl Acad Sci USA (76): 6632–6636, 1979.
Coughlin SR, Moskowitz MA, Zetter BR, Antoniades HN, Levine L: Stimulation of prostacyclin synthesis by platelet-derived growth factor. Nature (288): 600–602, 1980.
Coughlin SR, Moskowitz MA, Antoniades HN, Levine L: Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor. Proc Natl Acad Sci USA (78): 7134–7138, 1981.
Kreisberg JI, Karnovsky MJ, Levine L: Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells. Kidney Internat (22): 355–359, 1982.
Levine L, Morgan RA, Lewis RA, Austen KP, Clark DA, Marfat A, Corey EJ: Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis. Proc Natl Acad Sci USA (78): 7692–7696, 1981.
Snoek GT, Levine L: Requirements for protein synthesis and calcium for stimulation of prostaglandin synthesis in cultured rat liver cells by tumor promoters. Cancer Res (43): 4743–4746, 1983.
Bennett A: Prostaglandins and cancer. In: Karim SM (ed) Practical applications of prostaglandins and their synthesis inhibitors. MTP Press Ltd., Lancaster, 1979, pp. 149–188.
Karmali RA: Prostaglandins and cancer. Prostaglandins Med (5): 11–28, 1980.
Levine L: Arachidonic acid transformation and tumor production. Adv Cancer Res (35): 49–79, 1981.
Levine L, Worth N: Eicosapentaenoic acid: Its effects on arachidonic acid metabolism by cells in culture. J Allergy Clin Immunol. (In press).
Oliw E, Granstrom E, Anggard E: The prostaglandins and essential fatty acids. In: Pace-Asciak C, Granstrom E (eds) Prostaglandins and related substances. Elsevier, 1983, pp. 1–44.
Alam I, Voelkel EF, Tashjian AH Jr, Levine L: Analysis by high performance liquid chromatography of cyclooxygenase products of arachidonic acid metabolism in plasma of rabbits bearing the VX2 carcinoma. Prostaglandins Med (4): 227–237, 1980.
Fitzpatrick FA, Aguirre R, Pike JE, Lincoln FH: The stability of 13,14-dihydro-15-keto-PGE2. Prostaglandins (19): 917–913, 1980.
Granstrom E, Hamberg M, Hansson G, Kindahl H: Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins (19): 933–957, 1980.
Granstrom E, Kindahl H: Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: A method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11 β, 16-cyclo-PGE2. Adv Prostaglandin Thromboxane Res (6): 181–182, 1980.
Crumpton MJ: Conformational changes in sperm-whale metmyoglobin due to combination with antibodies to apomyoglobin. Biochem J (100): 223–232, 1965.
Axelrod L, Levine L: Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. Diabetes (31): 994–1001, 1982.
Alam I, Ohuchi K, Levine L: Determination of cyclooxygenase products and prostaglandin metabolites using high pressure liquid chromatography and radioimmunoassay. Anal Biochem (93): 339–345, 1979.
Rigas B, Lewis RA, Austen RA, Corey EJ, Levine L: Identification and quantitation of arachidonic acid metabolic products in rabbit, rat and human saliva. Archs oral Biol (28): 1031–1035, 1983.
Levine L, Cernosek RMG, Van Vunakis H: Specificities of prostaglandins B1, E1α , and F2α antigen-antibody reactions. J Biol Chem (246): 6782–6785, 1971.
Light RJ, Samuelsson B: Identification of prostaglandins in the gorgonian, Plexaura homomalla. Eur J Biochem (28): 232–240, 1972.
Lands WEM, LeTellier PR, Rome LH, Vanderhoek JY: Inhibition of prostaglandin biosynthesis. In: Bergstrom S (ed) Advances in the biosciences (9). 1973, pp. 15–28.
Nugteren DH: Arachidonate lipoxygenase in blood platelets. Biochim Biophys Acta (380): 299–307, 1975.
Levine L, Kobayashi T: Detection of compounds immunologically related to arachidonic acid transformation products in extracts of invertebrates. Prostaglandins Leukotrienes Med (12): 357–369, 1983.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Levine, L. (1985). Radioimmunoassay of Eicosanoids Associated with Tumor Growth. In: Lands, W.E.M. (eds) Biochemistry of Arachidonic Acid Metabolism. Prostaglandins, Leukotrienes, and Cancer, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2597-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2597-0_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9627-0
Online ISBN: 978-1-4613-2597-0
eBook Packages: Springer Book Archive