Sudden Cardiac Death — Failure or Effect of Antiarrhythmic Drug Therapy?

  • Ronald W. F. Campbell
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 47)


Cardiac arrhythmias probably underlie the majority of incidents of sudden cardiac death. Data from out-of-hospital rescue squads1,2, from coronary care units3 and from chance events captured on dynamic ECG recorders4 show that ventricular tachyarrhythmias (ventricular tachycardia, ventricular flutter and ventricular fibrillation) are the commonest arrhythmias implicated.


Sudden Cardiac Death Ventricular Fibrillation Antiarrhythmic Drug Ventricular Tachyarrhythmia Ventricular Ectopic Beat 
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  1. 1.
    Schaffer WA, Cobb LA. Recurrent ventricular fibrillation and modes of death in survivors of out-of-hospital ventricular fibrillation. New Eng J Med 293:259–262, 1975PubMedCrossRefGoogle Scholar
  2. 2.
    Liberthson RR, Nagel EL, Hirschman JC, Nussenfeld SR, Blackbourne 3D, Davis JH. Pathophysiologic observations in prehospital ventricular fibrillation and sudden cardiac death. Circulation 49:790–798, 1974PubMedGoogle Scholar
  3. 3.
    Julian DG, Valentine PA, Miller GG. Disturbances of rate rhythm and conduction in acute myocardial infarction. Am J Med 37:915–927, 1964PubMedCrossRefGoogle Scholar
  4. 4.
    Roelandt J, Klootwijk J, Lumsen J, Janse MJ. Sudden death during long term ambulatory monitoring. Eur Heart J 5:7–20, 1984PubMedGoogle Scholar
  5. 5.
    Adgey AAJ, Allen JD, Geddes JS, James RGG, Webb SW, Zaida SA, Pantridge JF. Acute phase of myocardial infarction. Lancet 2:501–504, 1971PubMedCrossRefGoogle Scholar
  6. 6.
    Lie KI, Liem KL, Schuilenberg RM, David GK, Durrer D. Early identification of patients developing late in-hospital ventricular fibrillation after discharge from the coronary care unit. A 5.5 year retrospective study of 1897 patients. Am J Cardiol 41:674–677, 1978PubMedCrossRefGoogle Scholar
  7. 7.
    Hauer RNW, Lie KI, Liem KL, Durrer D. Long-term prognosis in patients with bundle branch block complicating acute anteroseptal infarction. Am J Cardiol 49:1581–1585, 1982.PubMedCrossRefGoogle Scholar
  8. 8.
    Geddes JS, Adgey AAJ, Pantridge JF. Prognosis after recovery from ventricular fibrillation complicating ischaemic heart disease. Lancet 2:273–275, 1969.Google Scholar
  9. 9.
    McKenna WJ, England D, Doi YL, Deanfield JE, Oakley CM, Goodwin JF. Arrhythmia in hypertrophic cardiomyopathy: I Influence on prognosis. Br Heart J 46:168–172, 1981.PubMedCrossRefGoogle Scholar
  10. 10.
    Horowitz LN, Josephson ME, Kastor JA. Intracardiac electrophysiologic studies as a method for the optimization of drug therapy in chronic ventricular arrhythmia. Prog Cardiovasc Dis 23:81–98, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Campbell RWF. Does non beta-blocking antiarrhythmic therapy prevent sudden cardiac death? In:Morganroth J, Moore EN (eds) Sudden death and congestive heart failure: diagnosis and treatment. Martinus Nijhoff, The Hague, 1983, pp l40–154.Google Scholar
  12. 12.
    Myerburg RJ, Conde C, Sheps DS, Appel RA, Kiem I, Sung RJ, Castellanos A. Antiarrhythmic drug therapy in survivors of pre-hospital cardiac arrest: comparison of effects on chronic ventricular arrhythmias and recurrent cardiac arrest. Circulation 59:855–863, 1979.PubMedGoogle Scholar
  13. 13.
    Ruskin JN, DiMarco JP, Garan H. Out-of-hospital cardiac arrest. N Engl J Med 30:607–613, 1980.CrossRefGoogle Scholar
  14. 14.
    Horn HR, Hadidian Z, Johnson JL, Vassallo HG, Williams JH, Young MD. III. Chronic tocainide therapy studies. Safety evaluation of tocainide in the American emergency use program. Am Heart J 100:1037–1040, 1980.PubMedCrossRefGoogle Scholar
  15. 15.
    Ryden L, Ariniego R, Amman K, Herlitz J, Hjalmarson A, Holberg S, Reyes C, Smedgard P, Swedberg K, Vedin A, Waagstein F, Waldenstrom A, Wilhelmsson C, Wedel H, Yamamoto M. A double-blind trial of metoprolol in acute myocardial infarction. Effects on ventricular tachyarrhythmias. New Engl J Med 308:614–618, 1983.PubMedCrossRefGoogle Scholar
  16. 16.
    The Norwegian Muticenter Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. New Engl J med 304:801–807, 1981.CrossRefGoogle Scholar
  17. 17.
    B-Blocker Heart Attack Trial Research Group. A randomized trial of propranalol in patients with acute myocardial infarction. JAMA 247:1707–1714, 1982.CrossRefGoogle Scholar
  18. 18.
    Hjalmarson A, Herlitz J, Malek I, Ryden L, Vedin A, Waldenstrom A, Wedel H, Elmfeldt D, Holmberg S, Nyberg G, Swedberg K, Waagstein F, Waldenstrom J, Wilhelmsen L, Wilhelmsson C. Effect on mortality of metoprolol in acute myocardial infarction. A double blind randomized trial. Lancet 2:823–827, 1981.PubMedCrossRefGoogle Scholar
  19. 19.
    Schwartz PJ. The idiopathic long QT syndrome. The need for a prospective registry. Eur Heart J 4:529–531, 1983PubMedGoogle Scholar
  20. 20.
    McKenna WJ. Arrhythmia and prognosis in hypertrophic cardiomyopathy. Eur Heart J 4(suppl F): 225–234, 1983.PubMedGoogle Scholar
  21. 21.
    Winkle RA, Mason JW, Griffin JC, Ross D. Malignant ventricular tachyarrhythmias associated with the use of encainide. Am Heart J 102:854–864, 1981.Google Scholar
  22. 22.
    Nicholson MR, Campbell RWF, Julian DG. Ventricular tachycardia — management with encainide.(abs) Circulation 64:37, 1981Google Scholar
  23. 23.
    Kennelly BM. Comparison of lidoflazine and quinidine in prophylactic treatment of arrhythmias. Br Heart J 39:540–546, 1977.PubMedCrossRefGoogle Scholar
  24. 24.
    Ruskin JN, McGovern B, Garan H, DiMarco JP, Kelly E. Antiarrhythmic drugs: a possible cause of out-of-hospital cardiac arrest. N Engl J Med 309:1302–1306, 1983.PubMedCrossRefGoogle Scholar
  25. 25.
    Denes P, Gabster A, Huang SK. Clinical, electrocardiographic and follow-up observations in patients having ventricular fibrillation during Holter monitoring. Role of quinidine therapy. Am J Cardiol 48:9–16, 1981.PubMedCrossRefGoogle Scholar
  26. 26.
    McGovern B, Garan H, Kelly, Ruskin JN. Adverse reactions during treatment with amiodarone hydrochloride. Br Med J 287:175–180, 1983CrossRefGoogle Scholar
  27. 27.
    Nathan AW, Hellestrand KJ, Bexton RS, Banim SO, Spurrell RAJ, Camm AJ. Proarrhythmic effect of the new antiarrhythmic agent flecainide acetate. Am Heart J 107:222–228, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Ronald W. F. Campbell

There are no affiliations available

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