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Sudden Cardiac Death — Failure or Effect of Antiarrhythmic Drug Therapy?

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Cardiac Arrhythmias: New Therapeutic Drugs and Devices

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 47))

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Abstract

Cardiac arrhythmias probably underlie the majority of incidents of sudden cardiac death. Data from out-of-hospital rescue squads1,2, from coronary care units3 and from chance events captured on dynamic ECG recorders4 show that ventricular tachyarrhythmias (ventricular tachycardia, ventricular flutter and ventricular fibrillation) are the commonest arrhythmias implicated.

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References

  1. Schaffer WA, Cobb LA. Recurrent ventricular fibrillation and modes of death in survivors of out-of-hospital ventricular fibrillation. New Eng J Med 293:259–262, 1975

    Article  PubMed  CAS  Google Scholar 

  2. Liberthson RR, Nagel EL, Hirschman JC, Nussenfeld SR, Blackbourne 3D, Davis JH. Pathophysiologic observations in prehospital ventricular fibrillation and sudden cardiac death. Circulation 49:790–798, 1974

    PubMed  CAS  Google Scholar 

  3. Julian DG, Valentine PA, Miller GG. Disturbances of rate rhythm and conduction in acute myocardial infarction. Am J Med 37:915–927, 1964

    Article  PubMed  CAS  Google Scholar 

  4. Roelandt J, Klootwijk J, Lumsen J, Janse MJ. Sudden death during long term ambulatory monitoring. Eur Heart J 5:7–20, 1984

    PubMed  CAS  Google Scholar 

  5. Adgey AAJ, Allen JD, Geddes JS, James RGG, Webb SW, Zaida SA, Pantridge JF. Acute phase of myocardial infarction. Lancet 2:501–504, 1971

    Article  PubMed  CAS  Google Scholar 

  6. Lie KI, Liem KL, Schuilenberg RM, David GK, Durrer D. Early identification of patients developing late in-hospital ventricular fibrillation after discharge from the coronary care unit. A 5.5 year retrospective study of 1897 patients. Am J Cardiol 41:674–677, 1978

    Article  PubMed  CAS  Google Scholar 

  7. Hauer RNW, Lie KI, Liem KL, Durrer D. Long-term prognosis in patients with bundle branch block complicating acute anteroseptal infarction. Am J Cardiol 49:1581–1585, 1982.

    Article  PubMed  CAS  Google Scholar 

  8. Geddes JS, Adgey AAJ, Pantridge JF. Prognosis after recovery from ventricular fibrillation complicating ischaemic heart disease. Lancet 2:273–275, 1969.

    Google Scholar 

  9. McKenna WJ, England D, Doi YL, Deanfield JE, Oakley CM, Goodwin JF. Arrhythmia in hypertrophic cardiomyopathy: I Influence on prognosis. Br Heart J 46:168–172, 1981.

    Article  PubMed  CAS  Google Scholar 

  10. Horowitz LN, Josephson ME, Kastor JA. Intracardiac electrophysiologic studies as a method for the optimization of drug therapy in chronic ventricular arrhythmia. Prog Cardiovasc Dis 23:81–98, 1980.

    Article  PubMed  CAS  Google Scholar 

  11. Campbell RWF. Does non beta-blocking antiarrhythmic therapy prevent sudden cardiac death? In:Morganroth J, Moore EN (eds) Sudden death and congestive heart failure: diagnosis and treatment. Martinus Nijhoff, The Hague, 1983, pp l40–154.

    Google Scholar 

  12. Myerburg RJ, Conde C, Sheps DS, Appel RA, Kiem I, Sung RJ, Castellanos A. Antiarrhythmic drug therapy in survivors of pre-hospital cardiac arrest: comparison of effects on chronic ventricular arrhythmias and recurrent cardiac arrest. Circulation 59:855–863, 1979.

    PubMed  CAS  Google Scholar 

  13. Ruskin JN, DiMarco JP, Garan H. Out-of-hospital cardiac arrest. N Engl J Med 30:607–613, 1980.

    Article  Google Scholar 

  14. Horn HR, Hadidian Z, Johnson JL, Vassallo HG, Williams JH, Young MD. III. Chronic tocainide therapy studies. Safety evaluation of tocainide in the American emergency use program. Am Heart J 100:1037–1040, 1980.

    Article  PubMed  CAS  Google Scholar 

  15. Ryden L, Ariniego R, Amman K, Herlitz J, Hjalmarson A, Holberg S, Reyes C, Smedgard P, Swedberg K, Vedin A, Waagstein F, Waldenstrom A, Wilhelmsson C, Wedel H, Yamamoto M. A double-blind trial of metoprolol in acute myocardial infarction. Effects on ventricular tachyarrhythmias. New Engl J Med 308:614–618, 1983.

    Article  PubMed  CAS  Google Scholar 

  16. The Norwegian Muticenter Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. New Engl J med 304:801–807, 1981.

    Article  Google Scholar 

  17. B-Blocker Heart Attack Trial Research Group. A randomized trial of propranalol in patients with acute myocardial infarction. JAMA 247:1707–1714, 1982.

    Article  Google Scholar 

  18. Hjalmarson A, Herlitz J, Malek I, Ryden L, Vedin A, Waldenstrom A, Wedel H, Elmfeldt D, Holmberg S, Nyberg G, Swedberg K, Waagstein F, Waldenstrom J, Wilhelmsen L, Wilhelmsson C. Effect on mortality of metoprolol in acute myocardial infarction. A double blind randomized trial. Lancet 2:823–827, 1981.

    Article  PubMed  CAS  Google Scholar 

  19. Schwartz PJ. The idiopathic long QT syndrome. The need for a prospective registry. Eur Heart J 4:529–531, 1983

    PubMed  CAS  Google Scholar 

  20. McKenna WJ. Arrhythmia and prognosis in hypertrophic cardiomyopathy. Eur Heart J 4(suppl F): 225–234, 1983.

    PubMed  Google Scholar 

  21. Winkle RA, Mason JW, Griffin JC, Ross D. Malignant ventricular tachyarrhythmias associated with the use of encainide. Am Heart J 102:854–864, 1981.

    Google Scholar 

  22. Nicholson MR, Campbell RWF, Julian DG. Ventricular tachycardia — management with encainide.(abs) Circulation 64:37, 1981

    Google Scholar 

  23. Kennelly BM. Comparison of lidoflazine and quinidine in prophylactic treatment of arrhythmias. Br Heart J 39:540–546, 1977.

    Article  PubMed  CAS  Google Scholar 

  24. Ruskin JN, McGovern B, Garan H, DiMarco JP, Kelly E. Antiarrhythmic drugs: a possible cause of out-of-hospital cardiac arrest. N Engl J Med 309:1302–1306, 1983.

    Article  PubMed  CAS  Google Scholar 

  25. Denes P, Gabster A, Huang SK. Clinical, electrocardiographic and follow-up observations in patients having ventricular fibrillation during Holter monitoring. Role of quinidine therapy. Am J Cardiol 48:9–16, 1981.

    Article  PubMed  CAS  Google Scholar 

  26. McGovern B, Garan H, Kelly, Ruskin JN. Adverse reactions during treatment with amiodarone hydrochloride. Br Med J 287:175–180, 1983

    Article  CAS  Google Scholar 

  27. Nathan AW, Hellestrand KJ, Bexton RS, Banim SO, Spurrell RAJ, Camm AJ. Proarrhythmic effect of the new antiarrhythmic agent flecainide acetate. Am Heart J 107:222–228, 1984.

    Article  PubMed  CAS  Google Scholar 

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© 1985 Martinus Nijhoff Publishing, Boston

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Campbell, R.W.F. (1985). Sudden Cardiac Death — Failure or Effect of Antiarrhythmic Drug Therapy?. In: Morganroth, J., Moore, E.N. (eds) Cardiac Arrhythmias: New Therapeutic Drugs and Devices. Developments in Cardiovascular Medicine, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2595-6_12

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  • DOI: https://doi.org/10.1007/978-1-4613-2595-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9626-3

  • Online ISBN: 978-1-4613-2595-6

  • eBook Packages: Springer Book Archive

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