Abstract
Although many animal models are useful for evaluating new antiarrhythmic agents, it must be admitted that no animal model is ideal, nor can any single animal model alone predict antiarrhythmic efficacy in man. The selection of which animal model(s) to use depends first of all on whether one is “screening” for a new active compound or alternatively, “evaluating” an already identified active antiarrhythmic drug. This paper will deal primarily with models designed to evaluate mechanisms of action and effectiveness of new antiarrhythmic agents.
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References
Moore EN and Spear JF: Acute animal models for the study of antiarrhythmic drugs for the prevention of sudden coronary death. In: Clinical Pharmacology of Antiarrhythmic Therapy. Ed. Lucchesi, BR, Dingell, JV and Schwarz RP Jr. Raven Press, N.Y. pp. 31–46, 1984.
Wiggers, CJ, and Wegria R: Ventricular fibrillation due to a single localized induction and condenser shock applied during the vulnerable phase of ventricular systole. Am. J. Physiol. 128: 500–505.
Euler DE and Moore EN: Continuous fractionated electrical activity after stimulation of the ventricles during the vulnerable period: evidence for local reentry. Am. J. Cardiol. 46: 783–791, 1980.
Han J: Ventricular vulnerability during acute coronary occlusion. Am. J Cardiol. 24: 857–864, 1969.
Greenberg, HM and Dwyer, EM. Eds. Sudden Coronary Death Ann. NY Acad. Sci. 382: 1–484, 1982.
Kaplinsky, E, Ogawa S, Balke CW and Dreifus LS: Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model. Circ. 60: 397–403, 1979.
Harris, AS and Rojas, AG: Initiation of ventricular fibrillation due to coronary occlusion. Exp. Med. Surg. 1: 105–122, 1943.
Moore, EN, Spear, JF, Feldman HS and Moller R: Electrophysiological properties of a new antiarrhythmic drug — Tocainide. Am. J. Cardiol. 41: 703–708, 1978.
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© 1985 Martinus Nijhoff Publishing, Boston
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Moore, E.N., Spear, J.F. (1985). What Animal Models are Useful in Selecting New Antiarrhythmic Drugs?. In: Morganroth, J., Moore, E.N. (eds) Cardiac Arrhythmias: New Therapeutic Drugs and Devices. Developments in Cardiovascular Medicine, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2595-6_1
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DOI: https://doi.org/10.1007/978-1-4613-2595-6_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9626-3
Online ISBN: 978-1-4613-2595-6
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