Liver Cancer pp 297-312 | Cite as

Radiation Therapy of Hepatobiliary Tumors

  • Steven A. Leibel
Part of the Developments in Oncology book series (DION, volume 30)


External beam radiation therapy has played a limited role in the management of patients with hepatic or extrahepatic biliary carcinoma. The dose of radiation that can be administered to the liver or extrahepatic biliary tract is limited by the radiation tolerance of the normal tissues. The conclusion that radiation therapy is of little benefit to patients with hepatic malignancies has been based on the results of treatment using doses of 2,000–3,000 rad, a dose which is insufficient to locally control solid tumors. However, it has been demonstrated that external beam irradiation can result in significant symptomatic palliation in patients with metastatic disease to the liver. Response rates may be enhanced by combining radiation therapy with chemotherapy [1] or other agents which selectively sensitize the tumor relative to the normal tissue [2]. Ongoing research indicates that improved response rates may be achieved in primary hepatoma by multimodality programs combining radiation therapy, chemotherapy, and radiolabeled antibodies [3].


Hepatic Metastasis External Beam Irradiation Gallbladder Carcinoma Extrahepatic Bile Duct Hepatic Malignancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Martinus Nijhoff Publishing, Boston/Dordrecht/Lancaster 1985

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  • Steven A. Leibel

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