Depression of Glucose Transport in the Myocardium by Elevated Fatty Acids: Regulatory Feedback Affected by Stress

  • I. Bihler
  • P. C. Sawh
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 46)


Of the numerous manifestations of acute stress one of the more prominent is the mobilization of fatty acids and their increased utilization. This metabolic adjustment has a variety of consequences, one of which is the supression of glucose utilization by cardiac and skeletal muscle.


Glucose Transport Fatty Acid Oxidation Glucose Utilization Sugar Transport Glucose Transport System 
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  1. 1.
    Cahill GF: Physiology of insulin in man. Diabetes (20): 785–799, 1971.PubMedGoogle Scholar
  2. 2.
    Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose-fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet (1): 790–794, 1963.PubMedGoogle Scholar
  3. 3.
    Neely JR, Bowman RH, Morgan HE: Effects of ventricular pressure development and palmitate on glucose transport. Am J Physiol (216): 804–811, 1969.PubMedGoogle Scholar
  4. 4.
    Morgan HE, Henderson MJ, Regen DM, Park CR: Regulation of glucose uptake in muscle. 1) The effects of insulin and anoxia on transport and phosphorylation in the isolated perfused heart of normal rats. J Biol Chem (236): 253–261, 1961.PubMedGoogle Scholar
  5. 5.
    Elbrink J, Bihler I: Membrane transport: Its relation to cellular metabolic rates. Science (188): 1177–11842+1975.PubMedCrossRefGoogle Scholar
  6. 6.
    Bihler I, Ho TK, Sawh PC: Isolation of Ca -tolerant myocytes from adult rat heart. Can J Physiol Pharmacol (62): 581–588, 1984.PubMedCrossRefGoogle Scholar
  7. 7.
    Bihler I, Sawh PC: Membrane transport of sugars and its Ca2+-dependent regulation in isolated cardiac myocytes. Fed Proc (43): 771, 1984.Google Scholar
  8. 8.
    Sawh PC, Bihler I: The perifused left atrium: A preparation for studies on sugar transport in the myocardium. Can J Physiol Pharmacol (54): 708–713, 1976.PubMedCrossRefGoogle Scholar
  9. 9.
    Kono T, Colowick SP: Stereospecific sugar transport caused by uncouplers and SH inhibitors in rat diaphragm. Arch Biochem Biophys (93): 514–519, 1961.PubMedCrossRefGoogle Scholar
  10. 10.
    Bihler, I, Sawh PC: The effect of oxidative metabolic substrates on the membrane transport of sugars and on the action of ouabain in skeletal muscle in vitro. Can J Physiol Pharmacol (51): 371–377, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Tubbs PK, Chase JFA: Inhibition of carnitine palmitoyltransferase by 2-bromoacyl esters of coenzyme A and carnitine. Abstracts 4th Meeting FEBS. Universitetsforlaget, Oslo, 1967, abstr. No. 539.Google Scholar
  12. 12.
    Clausen T: The effect of insulin on glucose transport in muscle cells, Curr Topics Membr Transp (6): 169–226, 1975.Google Scholar
  13. 13.
    Clausen T: The role of calcium in the activation of the glucose transport system. Cell Calcium (1): 311–325, 1980.CrossRefGoogle Scholar
  14. 14.
    Gomez F, Jequier E, Chabot V, Buber V, Felber J-P: Carbohydrate and lipid oxidation in normal human subjects: Its influence on glucose tolerance and insulin response to glucose. Metabolism (21): 381–391, 1972.PubMedCrossRefGoogle Scholar
  15. 15.
    Randle PJ: Apparent reversal of insulin resistance in cardiac muscle in alloxan-diabetes by 2-bromostearate. Nature (221): 777, 1969.PubMedCrossRefGoogle Scholar
  16. 16.
    Burgess RA, Butt WD, Baggaley A: Some effects of α-bromopalmitate, a inhibitor of fatty acid oxidation, on carbohydrate metabolism in the rat. Biochem J (109): 38P-39P, 1968.Google Scholar
  17. 17.
    Bihler I: Ionic effects in the regulation of sugar transport in muscle. In: Mehlman MA, Hanson RW (eds) The role of membranes in metabolic regulation. Academic Press New York, 1972, pp 411–422.Google Scholar
  18. 18.
    Bihler, I, Sawh PC: Effect of fatty acid oxidation on sugar transport in muscle. Fed Proc (31): 287 abs, 1972.Google Scholar
  19. 19.
    Bihler, I, Sawh PC: Dual effect of fatty acids on the regulation of sugar transport in heart muscle. Proc Can Fed Biol Soc (17): 147, 1974.Google Scholar
  20. 20.
    Nayler WG, Ferrari G, Williams A: Protective effect of pretreatment with Verapamil, Nifedipine and Propranolol on mitochondrial function in the ischemic and reperfused myocardium. Am J Cardiol (46): 242–248, 1980.PubMedCrossRefGoogle Scholar
  21. 21.
    Bihler, I, Bigornia L, MacDonald LM, Sawn PC: Stimulation of sugar transport in muscle by Li+: role of Ca Pharmacologist (22): 201, 1980.Google Scholar
  22. 22.
    Tsien RY: A non-disruptive technique for loading calcium buffers and indicators into cells. Nature (290): 527–528, 1981.PubMedCrossRefGoogle Scholar
  23. 23.
    Lopaschuk GD, Katz S, McNeill JH: The effect of alloxan and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylarnitines. Can J Physiol Pharmacol (61): 439–448, 1983.PubMedCrossRefGoogle Scholar
  24. 24.
    Werner JC, Schuler HG, Rannels A, Whitman V: Fatty acid metabolism in the isolated fetal and newborn pig heart. Fed Proc (42): 1257, 1983.Google Scholar
  25. 25.
    Paulson DJ, Ward K, Sheratt HSA, Shug AL: Effects of sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate on the metabolism and function of the ischemic myocardium. Fed Proc (43): 903, 1984.Google Scholar
  26. 26.
    Kolterman OG, Gray RS, Griffin J, Burstein P. Insel J, Scarlett JA, Olefsky JM: Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest (68): 937–969, 1981.CrossRefGoogle Scholar
  27. 27.
    Ciaraldi TP, Kolterman OG, Scarlett JA, Kao M, Olefsky JM: Role of glucose transport in the postreceptor defect of non-insulin-dependent diabetes mellitus. Diabetes (31): 1016–1022, 1982.PubMedGoogle Scholar
  28. 28.
    Bachman E, Weber E, Zbinden G: Biochemical aspects of cardiotoxic effects of a novel type hypoglycemic agent in rats. J Mol Cell Cardiol (15): Suppl. 1, p. 67, 1983.Google Scholar
  29. 29.
    Bielefeld DR, Vary TC, Neely JR: site of inhibition of fatty acid oxidation by lactate and oxfenicine in cardiac muscle. Fed Proc (42): 1258, 1983.Google Scholar
  30. 30.
    Rosen P, Reinauer H: The effect of a new carnitine-palmitoyltransferase-inhibitor on glucose metabolism and insulin sensitivity of the rat heart. J Mol Cell Cardiol (15): Suppl. 1, p. 353, 1983.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • I. Bihler
    • 1
  • P. C. Sawh
    • 1
  1. 1.Department of Pharmacology and TherapeuticsUniversity of ManitobaWinnipegCanada

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