Abstract
Diabetics exhibit a higher risk of developing cardiovascular disease than the normal population (1). Recently, alterations in the cardiovascular actions of the eicosanoids have been implicated in the vascular disorders associated with diabetes mellitus (2). In this regard, we have shown that vascular tissue from diabetic animals exhibits increased reactivity towards endoperoxide analogs (3), platelet produced eicosanoids (4) and leukotrienes (5). We have also shown that vascular tissue from diabetic rats develop altered production of prostacyclin (3) and leukotrienes (6).
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References
Garcia MJ, McNamara PM, Gordon T, Kannel W: Morbidity and mortality in diabetics in the Framingham population. Diabetes (23):105–111, 1974.
Naveh-Floman N, Maisseiev 3: Prostanoids and thromboxane A2 involvement in diabetic retinopathy. Metab Pediat Syst Ophthal (6):321–325, 1982.
Roth DM, Reibel DK, Lefer AM: Vascular responsiveness and eicosanoid production in diabetic rats. Diabetologia (24):372–376, 1983.
Reibel DK, Roth DM, Lefer BL, Lefer AM: Hyperreactivity of coronary vasculature in platelet-perfused hearts from diabetic rats. Am 3 Physiol (245):H640-H645, 1983.
Roth DM, Reibel DK, Lefer AM: Altered coronary vascular responsiveness to leukotrienes in alloxan-diabetic rats. Circ Res (54):388–395, 1984.
Roth DM, Smith JB, Lefer AM: Leukotriene production in isolated tissues of diabetic rats. Prostaglandins Leukotrienes Med 1984.
Broderick R, Tulenko T: Cholesterol increases norepinephrine (NE) sensitivity in perfused rabbit femoral arteries. Fed Proc (42):1347, 1983.
Spector AA, Hoak JC, Fry GL, Denning GM, Stoll LL, Smith JB: Effect of fatty acid modification on prostacyclin production by cultured human endothelial cells. J Clin Invest (65):1003–1012, 1980.
Raabo E, Terkildsen TC: On the enzymatic determination of blood glucose. Scand J Clin Lab Invest (12):402–408, 1960.
Ingerman-Wojenski C, Silver MJ, Smith JB, Macarak E: Bovine endothelial cells in culture produce thromboxane as well as prostacyclin. J Clin Invest (67):1292–1296, 1981.
Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol (37):911–917, 1959.
Rudel LL, Morris MD: Determination of cholesterol using O-phthalaldehyde. J Lipid Res (14):364–386, 1973.
Bartlett GB: Phosphorous assay in column chromatography. J Biol Chem (234):466–468, 1959.
Harrison HE, Johnson M: Vascular prostacyclin release and metabolic derangement in diabetes. Horm Metab Res Suppl (11):43–49, 1981.
Silberbauer K, Schernthaner G, Sinzinger H, Piza-Katzer H, Winter M: Decreased vascular prostacyclin in juvenile-onset diabetes. N Engl J Med (300):366–367, 1979.
Wey H, Subbiah MTR: 6-keto-PGF, synthesis in diabetic rat aorta: effect of substrate concentration and cholesterol feeding. Proc Soc Biol Med (171):251–257, 1982.
Rogers SP, Larkins RG: Production of 6-oxo-PGF1 by rat aorta: influence of diabetes, insulin treatment, and caloric deprivation. Diabetes (30):935–939, 1981.
Landgraf-Leurs MMC, Landgraf R, Loy A, Weber PC, Herberg LL: Aggregation and thromboxane formation by platelets and vascular prostacyclin production from BB rats. An animal model for type 1 diabetes. Prostaglandins (24):37–47, 1982.
Galli C, Agradi E, Petroni A, Tremoli E: Differential effects of dietary fatty acids on the accumulation of arachidonic acid and its metabolic conversion through cyclooxygenase and lipoxygenase in platelets and vascular tissue. Lipids (16):165–172, 1981.
Holman RT, Johnson SB, Gerrard JM, Mauer SM, Kupcho-Sandberg S, Brown DM: Arachidonic acid deficiency in streptozotocin-induced diabetes. Proc Nat Acad Sci USA (80):2375–2379, 1983.
Sabine JR: Membrane homeostasis: Is there an optimum level of membrane cholesterol? Bioscience Rep (3):337–344, 1983.
Yeagle PL: Cholesterol modulation of Na+ K+) — ATPase ATP hydrolyzing activity in the human erythrocyte. Biochem Biophys Acta (727):39–44, 1983.
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© 1985 Martinus Nijhoff Publishing, Boston
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Roth, D.M., Reibel, D.K., Lefer, A.M. (1985). Lipid Analysis of Aortic Tissue from Alloxan-Diabetic Rats. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pathogenesis of Stress-Induced Heart Disease. Developments in Cardiovascular Medicine, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2589-5_35
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DOI: https://doi.org/10.1007/978-1-4613-2589-5_35
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9623-2
Online ISBN: 978-1-4613-2589-5
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