Abstract
Prostacyclin (PGI2), a major product of prostaglandin endoperoxide (PGH2) metabolism in blood vessels, has potent vasodilator and platelet antiaggregatory activity (1). Therefore, modulation of PGI2 synthetase activity is of prime physiological importance in the regulation of blood vessel function. Reducing agents, such as GSH, have been reported to augment prostaglandin production by protecting the cyclooxygenase enzyme system (arachidonic acid → PGH2) from self-catalyzed deactivation (2). However, little evidence exists for the effects of these agents upon augmenting prostacyclin synthetase activity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Vane JR: Adventures and excursions in bioassay: the stepping stones to prostacyclin. Br. J. Pharmacol. (79):821–838, 1983.
Egan RW, Paxton J, Kuehl FA, Jr: Mechanism for irreversible self-deactivation of prostaglandin synthetase. J. Biol. Chem. (251):7329–7335, 1976.
Lowry OH, Rosebrough NJ, Farr AL, Randall RS: Protein measurement with folin phenol reagent. J. Biol. Chem. (193):265–275, 1951.
Kerstein MD, Saroyan M, McMullen-Laird M, Hyman AL, Kadowitz PJ, McNamara DB: Metabolism of prostaglandins in human saphenous vein. J. Surg. Res. (35):91–100, 1983.
She HS, McNamara DB, Spannhake EW, Hyman AL, Kadowitz PJ: Metabolism of prostaglandin endoperoxide by microsomes from cat lung. Prostaglandins (21):531–541, 1981.
McNamara DB, Roulet MJ, Hyman AL, Kadowitz PJ: Characterization of a calcium-accumulating mitochondrial fraction isolated from bovine intrapulmonary vein. Can. J. Physiol. Pharmacol. (57): 1107–1113, 1979.
McNamara DB, Roulet MJ, Gruetter CA, Hyman AL, Kadowitz PJ: Correlation of prostaglandin-induced mitochondrial calcium release with contraction in bovine intrapulmonary vein. Prostaglandins (20):311–320, 1980.
Gerritsen ME, Printz MP: Sites of prostaglandin synthesis in the bovine heart and isolated bovine coronary microvessels. Circ. Res. (49):1152–1163, 1981.
Meister A, Anderson ME: Glutathione. Ann. Rev. Biochem. (52): 711–760, 1983.
Farooqui MYH, Ahmed A: Circadian periodicity of tissue glutathione and its relationship with lipid peroxidation in rats. Life Sci. (34):2413–2418, 1984.
Thomas G, Skrinska V, Lucas F, Butkus A: Platelet glutathione and thromboxane synthesis in diabetes mellitus. Fed. Proc. (43): 1040, 1984.
Romson JL, Hook BG, Rigot VH, Schork MA, Swanson DP, Lucchesi BR: The effect of ibuprofen on accumulation of Indium-111-labeled platelets and leukocytes in experimental myocardial infarction. Circulation (66): 1002–1011, 1982.
Fantone JC, Kinnes DA: Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils. Biochem. Biophys. Res. Commun. (113):506–512, 1983.
Lefer AM, Ogletree MS, Smith JB, Silver MJ, Nicolaou KC, Gasic GP: Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial infarction. Science (200): 52–54, 1978.
Okuma M, Takayma H, Uchino H: Generation of prostacyclin-!ike substance and lipid peroxidation in vitamin E-deficient rats. Prostaglandins (19):527–536, 1980.
Needleman P: Organic nitrate metabolism. Ann. Rev. Pharmacol. (16):81–93, 1976.
Schror K, Grodzinska L, Darius H: Stimulation of coronary vascular prostacyclin and inhibition of human platelet thromboxane A2 after low dose nitroglycerin. Thromb. Res. (23):59–67, 1981.
Beetens JR, Claeys M, Herman AG: Vitamin C increases the formation of prostacyclin by aortic rings from various species and neutralizes the inhibitory effect of the 15-hydroxy-arachidonic acid. Br. J. Pharmacol. (80):249–254, 1983.
McMullen-Laird M, McNamara DB, Kerstein MD, Hyman AL, Kadowitz PJ: Human lung metabolism of prostaglandin endoperoxide. Circulation (66II):166, 1982.
McNamara DB, Hussey JL, Kerstein MD, Rosenson RJ, Hyman AL, Kadowitz PJ: Modulation of prostacyclin synthetase and unmasking of PGE2 isomerase in bovine coronary arterial microsomes. Biochem. Biophys. Res. Commun. (118):33–39, 1984.
Hyman AL, Kadowitz PJ, Lands WEM, Crawford CG, Fried J, Barton J: Coronary vasodilator activity of 13,14-dehydroprosta-cyclin methyl ester: comparison with prostacyclin and other prostanoids. Proc. Natl. Acad. Sci. USA (75):3522–3526, 1978.
Bunting S, Moncada S, Vane JR: The prostacyclin-thromboxane A2 balance: pathophysiological and therapeutic implications. Br. Med. Bull. (39):271–276, 1983.
Carrier R, Cragoe EJ, Ethier D, Ford-Hutchinson AW, Girard Y, Hall RA, Hamel P, Rokach J, Share NN, Stone CA, Yusko P: Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung. Br. J. Pharmacol. (82):389–395, 1984.
Greenberg S: Effect of prostacyclin and 9α,11α-epoxymethano-prostaglandin H2 on calcium and magnesium fluxes and tension development in canine intralobar pulmonary arteries and veins. J. Pharmacol. Exp. Ther. (219):326–337, 1981.
Carsten ME, Miller JD: Effects of prostaglandins and oxytocin on calcium release from a uterine microsomal fraction. J. Biol. Chem. (252):1576–1581, 1977.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
McNamara, D.B. et al. (1985). Modulation of Coronary Arterial Prostacyclin Synthetase Activity. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pathogenesis of Stress-Induced Heart Disease. Developments in Cardiovascular Medicine, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2589-5_29
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2589-5_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9623-2
Online ISBN: 978-1-4613-2589-5
eBook Packages: Springer Book Archive