Stress-Limiting Systems of the Organism and their Role in Prevention of Ischemic Damages of the Heart

Abstract

It is known that evolutionally formed stress reaction is a necessary common link of the organism various responses to environmental factors. Nevertheless, in so-called hopeless conditions, when the factor affecting the organism is too strong or the environmental situation is too complex the adaptation appears to be impossible. In result, initial disturbances of the homeostasis induced by the environmental factor are preserved for a long time and stress-reaction stimulated by these disturbances achieves an excessive intensity and length. This is precisely the situation in which stress reaction can transform from a common link of adaptation to a common link of pathogenesis of different diseases from the stomach and duodenal ulcerous lesions to the heart ischemic disease and activated blastomatous growth. It means that the stress damage plays an important and sometimes a decisive role in the pathogenesis of major noninfectious diseases their prophylaxis and therapy being the main unsettled problem of modern medicine. Correspondingly, exploration of principles of preventing the stress damage is a necessary stage of the problem solution.