Abstract
Atherosclerosis is a multifactorial pathogenetic process, involving a number of environmental stimuli as primary factors in both the etiology and pathogenesis of the lesions (1). It seems clear for example that serum lipids, hypertension, and cigarette smoking all play roles in the determination of the geographic distribution of atherosclerosis, and within geographic areas, these variables seem to act as risk factors for extent and severity of atherosclerosis and its sequelae (coronary heart disease [CHD], cerebrovascular disease) (2,3). A close look at the evidence, reveals however, that a significant proportion of the variability in CHD and atherosclerosis is unexplained by these “traditional” risk factors (4). Most CHD does not occur in high risk groups and most high risk individuals do not get the disease (5). The primary risk factors, even when taken in combination, still fail to account for the appearance of symptoms in a majority of new CHD cases (6).
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© 1985 Martinus Nijhoff Publishing, Boston
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Kaplan, J.R., Manuck, S.B., Clarkson, T.B. (1985). Psychosocial Stress and Atherosclerosis in Cynomolgus Macaques. In: Beamish, R.E., Singal, P.K., Dhalla, N.S. (eds) Stress and Heart Disease. Developments in Cardiovascular Medicine, vol 45. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2587-1_21
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DOI: https://doi.org/10.1007/978-1-4613-2587-1_21
Publisher Name: Springer, Boston, MA
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