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Clinical and Biochemical Aspects of Stress and Cardiomyopathy

  • Michael L. Hess
  • H. Page Mauck
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 45)

Abstract

Clinically, a primary cardiomyopathy is defined as a left ventricular ejection fraction of less than 40% in the absence of coronary artery disease, valvular abnormalities or intracardiac shunts. This clinical syndrome thus represents a primary disease of cardiac muscle. The etiology of a cardiomyopathy process is often difficult to define. In the western world, the most common etiologies include ethanol, post viral, and a variety of pharmacological (e.g., anthracycline antibiotics) and toxic agents (e.g., radiation, cobalt and hydrocarbons) (1). The histopathology of all of these lesions tends to present as broad, pale staining myofibers with enlarged and peripheral nuclei and various degrees of necrosis and fibrosis (2). The role of environmental stress as a primary etiology is not well understood and is poorly documented.

Keywords

Sarcoplasmic Reticulum Oxygen Free Radical Squirrel Monkey Shock Stress Anthracycline Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Michael L. Hess
  • H. Page Mauck

There are no affiliations available

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