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RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding pp 76–92Cite as

A New Class of Human Endogenous Retroviral Genes

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Part of the book series: Developments in Oncology ((DION,volume 28))

Abstract

Several factors have been implicated in the etiology of human breast cancer. The potential involvement of members of the Retroviridae family of viruses has represented a major focus of investigation (1 for review). This is primarily a result of studies of mammary cancer in laboratory mice, where infectious type-B oncoviruses (mouse mammary tumor virus, MMTV) have been shown to be associated with a high incidence of mammary tumors. With the exception of species of the genus Mus (2,3) and Rattus (4), attempts to identify DNA sequences related to the MMTV genome in DNAs of all other mammalian species tested have not been consistently successful (5,6). Other studies (7,8), using liquid hybridization and MMTV cDNA probes, reported the presence of RNA species, in human mammary tumors, related to the viral genome. The lack of uniform probes, the potential for contamination of cDNA preparations with cellular DNA or RNA, and the relative lack of sensitivity of liquid hybridization techniques made these findings difficult to interpret.

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Author information

Authors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    Robert Callahan, Ing-Ming Chiu, Toby Horn, Igbal Ali, Joan Robbins, Stuart Aaronson & Jeffrey Schlom

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  1. Robert Callahan
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  2. Ing-Ming Chiu
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  3. Toby Horn
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  4. Igbal Ali
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  5. Joan Robbins
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  6. Stuart Aaronson
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  7. Jeffrey Schlom
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Editor information

Editors and Affiliations

  1. AMC Cancer Research Center, Denver, Colorado, USA

    Philip Furmanski , Jean Carol Hager  & Marvin A. Rich ,  & 

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© 1985 Martinus Nijhoff Publishing, Boston

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Callahan, R. et al. (1985). A New Class of Human Endogenous Retroviral Genes. In: Furmanski, P., Hager, J.C., Rich, M.A. (eds) RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding. Developments in Oncology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2583-3_7

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  • DOI: https://doi.org/10.1007/978-1-4613-2583-3_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9620-1

  • Online ISBN: 978-1-4613-2583-3

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