Bovine Leukemia Virus: Past, Present and Future
Enzootic bovine leukemia has been perceived as an infectious cancer since about 50 years. Appearance of tumor cases has been linked to introduction, in a naïve herd, of animals coming from a “tumor case” herd and experimental transmission experiments easily showed that an agent was indeed most probably involved. The exact nature of the agent remained elusive until 1969, when Miller and coworkers (1) observed virus particles in short term cultures of lymphocytes from animals in persistent lymphocytosis, a condition frequently associated with increased risk of leukemia. Since 1969, the virus itself, its host-range and mode of propagation, its interactions with the host and ways of leukemogenesis, ... have been the subject of intense investigation. The nucleotide sequence of several BLV proviruses is now known, thus allowing deep insight to be gained into virus integration and expression and hypotheses to be put forward about putative modes of action. Times are now ripe and the tools are available to undertake a detailed analysis of the chain of events that starts at infection and ends with full blow of the tumor phase. It had been observed, already in 1972 (2), that BLV behaved as a separate entity from the then known retroviruses.
KeywordsLong Terminal Repeat Bovine Leukemia Virus Nucleic Acid Binding Protein Amino Acid Sequence Data Feline Leukemia Virus
Unable to display preview. Download preview PDF.
- 1.Miller J.M., Miller L.D., Olson C. and Gillette K.G.: Virus-like particles in phytohaemagglutinin-stimulated lymphocyte cultures with reference to bovine lymphosarcoma. J. Nat. Cancer Inst. (43): 1297–1305, 1979.Google Scholar
- 5.Kashmiri S.V.S., Mehdi R. and Ferrer J.F.: Molecular cloning of covalently closed circular DNA of bovine leukemia virus. J. Virol. (49): 583–587, 1983.Google Scholar
- 10.Burny A., Bruck C., Cleuter Y., Couez D., Dekegel D., Deschamps J., Ghysdael J., Gilden R.V., Kettmann R., Marbaix G., Mammerickx M. and Portetelle D.: Leukemogenesis by bovine leukemia virus. In: Mechanisms of viral leukemogenesis vol. 1, eds J. Goldmann and O. Jarrett, Edinburgh, Churchill Livingstone. 1976,pp. 229–260.Google Scholar
- 12.Czernilofsky A.P., De Lorbe W., Swanstrom R., Varmus H.E., Bishop J.M., Fischer E. and Goodman H.M.: The nucleotide sequence of an untranslated but conserved domain at the 3’ end of the avian sarcoma virus genome. Nucl. Ac. Res. (8): 2967 2984, 1980.Google Scholar
- 17.Rice N.R., Stephens R.M., Couez D., Deschamps J., Kettmann R., Burny A. and Gilden R.V.: The nucleotide sequence of the env gene and post-env region of bovine leukemia virus. Virology, in press, 1984.Google Scholar
- 18.Schultz A.M., Copeland T.D. and Oroszlan S.: The envelope proteins of bovine leukemia virus: purification and sequence analysis. Virology 135, in press, 1984.Google Scholar
- 22.Burny A., Bruck C., Chantrenne H., Cleuter Y., Dekegel D., Ghysdael J., Kettmann R., Leclercq M., Leunen J., Mammerickx M. and Portetelle D.: Bovine leukemia virus: molecular biology and epidemiology. In: Viral Oncology, ed G. Klein. New York, Raven Press, 1980, pp. 231–289.Google Scholar
- 31.Bruck C., Rensonnet N., Portetelle D., Cleuter Y., Mammerickx M., Burny A., Mamoun R., Guillemain B., Van der Maaten M.J. and Ghysdael J.: Biologically active epitopes of bovine leukemia virus glycoprotein gp51: their dependence on protein glycosylation and genetic variability. Virology. In press, 1984.Google Scholar
- 33.Bruck C., Mathot S., Portetelle D., Franssen J.D., Herion P. and Burny A.: Monoclonal antibodies define eight independent antigenic sites on the bovine leukemia virus envelope glycoprotein gp51. Virology (122): 343–352, 1982a.Google Scholar
- 35.Bruck C., Portetelle D., Mammerickx M., Mathot S. and Burny A.: Epitopes of bovine leukemia virus glycoprotein gp51 recognized by sera of infected cattle and sheep. Leukaemia Res.8: in press, 1984.Google Scholar