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Chronic and Acute Leukemias in Adults pp 175–208Cite as

Chemosensitivity of In Vitro Colony Forming Units as a Predictor of Response to Antileukemic Drugs

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 26))

Abstract

Leukemia is a clonal disease secondary to malignant transformation of one or more normal hematopoietic stem cells. These leukemic stem cells are capable of proliferation and self renewal. They give rise to one or more dominant clones of cells that eventually fill the bone marrow and suppress normal hematopoiesis in the patient. At this time clinical disease becomes apparent with signs and symptoms of marrow failure. The population of blasts in acute leukemia contains cells capable of colony formation in culture [1–6]. These cells are called leukemic colony forming units, L-CFU. If the colonies are harvested from culture and replated, some also contain cells capable of forming colonies so that proliferation of stem cells capable of self renewal can be demonstrated. There is substantial evidence that L-CFU which replicate extensively in vitro and form large colonies are identical or closely related to the leukemic stem cell responsible for maintenance of the leukemic clone in the patient [7, 8].

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Authors
  1. John J. Hutton
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Editors and Affiliations

  1. Section of Medical Oncology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA

    Clara D. Bloomfield

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© 1985 Martinus Nijhoff Publishers, Boston

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Hutton, J.J. (1985). Chemosensitivity of In Vitro Colony Forming Units as a Predictor of Response to Antileukemic Drugs. In: Bloomfield, C.D. (eds) Chronic and Acute Leukemias in Adults. Cancer Treatment and Research, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2581-9_6

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  • DOI: https://doi.org/10.1007/978-1-4613-2581-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9619-5

  • Online ISBN: 978-1-4613-2581-9

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