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Study of Differentiation and Proliferation of Leukemic Cells Using Myeloid Leukemia Cell Lines

  • Chapter
Chronic and Acute Leukemias in Adults

Part of the book series: Cancer Treatment and Research ((CTAR,volume 26))

Abstract

The study of proliferation and differentiation of acute myelogenous leukemia cells is greatly aided by the establishment of human myeloid leukemia cell lines [1–8], (Table 1 and Figure 1). The leukemic lines are blocked at different stages of maturation: The KG-la cells are very young myeloblasts; KG-1 are myeloblasts; HL-60 are promyelocytes; ML-1 and 3 are myelomonoblasts; U937 and THP-1 are monocytoid lines; K562 and HEL are early myeloid blasts and/or erythroblasts. Cells of each of the lines except THP-1 have prominent chromosomal abnormalities and these same changes were also present in the blast cells of the patients. The KG-1, ML-1 and 3, HL-60, THP-1 and U937 cells can be triggered to differentiate to macrophage-like cells. The HL-60 cells can differentiate to granulocytes. The K562 and HEL cells can differentiate to more mature red cell precursors after exposure to several agents.

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  1. H. Phillip Koeffler
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  1. Section of Medical Oncology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA

    Clara D. Bloomfield

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© 1985 Martinus Nijhoff Publishers, Boston

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Koeffler, H.P. (1985). Study of Differentiation and Proliferation of Leukemic Cells Using Myeloid Leukemia Cell Lines. In: Bloomfield, C.D. (eds) Chronic and Acute Leukemias in Adults. Cancer Treatment and Research, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2581-9_2

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  • DOI: https://doi.org/10.1007/978-1-4613-2581-9_2

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