Abstract
The development and clinical use of plasma proteins has a history of sporadic quantum jumps coupled with years of stagnation. The quantum jumps occur with the development of new technology, whereas the stagnation occurs when there is unimaginative management of the plasma resource and lack of funding for new product development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cohn EJ, Strong LE, Hughes WL Jr, Mulford DJ, Ashworth JN, Melin M, Taylor HL: Preparation and properties of serum and plasma proteins. IV. A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids. J Am Chem Soc, 1946; 68: 459–75.
Bering EA Jr: Chemical, clinical, and immunological studies on the products of human plasma fractionation. XX. The development of fibrin foam as a hemostatic agent and for use in conjunction with human thrombin. J Clin Invest, 1944; 23: 586–90.
Bove JR: Fibrinogen — is the benefit worth the risk? Transfusion, 1978; 18: 129–36.
Alexander B, Landwehr G: Studies of hemophilia. II. The assay of the antihemophilic clot-promoting principle in normal human plasma with some observations on the relative potency of certain plasma fractions. J Clin Invest, 1948; 27: 98–105.
Melin M, Jansky JW, Leonardos G, Di Francesco A, Pennell RB, Tullis JL: The preparation of a prothrombincontaining fraction from human plasma by chromatography. Vox Sang, 1964; 9: 227 (abstract).
Curling JM (ed): Methods of Plasma Protein Fractionation. Academic Press, New York, 1980.
Choo KH, Gould KG, Rees DJG, Brownlee GG: Molecular cloning of the gene for human anti-haemophilic factor IX. Nature, 1982; 299: 178–80.
Chandra T, Kurachi K, Davie EW, Woo SLC: Induction of a1-antitrypsin mRNA and cloning of its cDNA. Biochem Biophys Res Commun, 1981; 103: 751–58.
Suggs SV, Wallace RB, Hirose T, Kawashima EH, Itakura K: Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human (32-microglobulin. Proc Natl Acad Sci USA, 1981; 78: 6613–17.
Lawn RM, Adelman J, Bock SC, Franke AE, Houck CM, Najarian RC, Seeburg PH, Wion KL: The sequence of human serum albumin cDNA and its expression in E. coli. Nucleic Acids Res, 1981; 9: 6103–14.
Ricca GA, Hamilton RW, McLean JW, Conn A, Kalinyak JE, Taylor JM: Rat ai-acid glycoprotein mRNA. Cloning of double-stranded eDNA and kinetics of induction of mRNA levels following acute inflammation. J Biol Chem, 1981; 256: 10362–68.
Crabtree GR, Kant JA: Molecular cloning of eDNA for the α, β, and γ chains of rat fibrinogen. A family of coordinately regulated genes. J Biol Chem, 1981; 256: 9718–23.
Odink KG, Fey G, Wiebauer K, Diggelmann H: Mouse complement components C3 and C4. Characterization of their messenger RNA and molecular cloning of complementary DNA for C3. J Biol Chem, 1981; 256: 1453–58.
Prochownik EV, Orkin SH: Isolation of the human anti-thrombin III gene. Blood, 1982; 60 (suppl. 1): 806 (abstract).
Sinkovics JG, Dreesman GR: Monoclonal antibodies of hybridomas. Rev Infect Dis, 1983; 5: 9–34.
Gadek JE, Hosea SW, Gelfand JA, Santaella M, Wickerhauser M, Triantaphyllopoulos DC, Frank MM: Replacement therapy in hereditary angioedema. Successful treatment of acute episodes of angioedema with partly purified Cl inhibitor. N Engl J Med, 1980; 302: 542–46.
Gadek JE, Klein HG, Holland PV, Crystal RG: Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects. J Clin Invest, 1981; 68: 1158–65.
Skillman JJ: Use of colloid in massive transfusions. In: Massive Transfusion in Surgery and Trauma, Collins JA, Murawski K, Shafer AW (eds). Alan R. Liss, New York, 1982: 65–68.
Smith T: Active immunity produced by so-called balanced or neutral mixtures of diphtheria toxin and antitoxin. J Exp Med, 1909; 11: 241–56.
Finn R, Clarke CA, Donohoe WTA, McConnell RB, Sheppard PM, Lehane D, Kulke W: Experimental studies on the prevention of Rh haemolytic disease. Br Med J, 1961; 1: 1486–90.
Pollack W, Gorman JG, Hager HJ, Freda VJ, Tripodi D: Antibody-mediated immune suppression to the Rh factor: animal models suggesting mechanism of action. Transfusion, 1968; 8: 134–45.
Freda VJ, Gorman JG, Pollack W: Rh Factor: prevention of isoimmunization and clinical trial on mothers. Science, 1966; 151: 828–30.
Chedid L, Parant M, Parant F, Boyer F: A proposed mechanism for natural immunity to enterobacterial pathogens. J Immunol, 1968; 100: 292–301.
Braude AI, Douglas H: Passive immunization against the local Shwartzman reaction. J Immunol, 1972; 108: 505–12.
Braude AI, Douglas H, Davis CE: Treatment and prevention of intravascular coagulation with antiserum to endotoxin. J Infect Dis, 1973; 128: S157–64.
Ziegler EJ, Douglas H, Sherman JE, Davis CE, Braude AI: Treatment of E. coli and Klebsiella bacteremia in agranulocytic animals with antiserum to a UDP-Gal epimerase-deficient mutant. J Immunol, 1973; 111: 433–38.
Ziegler EJ, McCutchan JA, Fierer J, Glauser MP, Sadoff JC, Douglas H, Braude AI: Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coll. N Engl J Med, 1982; 307: 1225–30.
Wyke RJ, Tsiquaye KN, Thornton A, White Y, Portmann B, Das PK, Zuckerman AJ, Williams R: Transmission of non-A non-B hepatitis to chimpanzees by factor-IX concentrates after fatal complications in patients with chronic liver disease. Lancet, 1979; 1: 520–24.
Sugg U, Schnaidt M, Schneider W, Lissner R: Clotting factors and non-A, non-B hepatitis. N Engl J Med, 1980; 303: 943.
Gellis SS, Neefe JR, Stokes J Jr, Strong LE, Janeway CA, Scatchard G: Chemical, clinical, and immunological studies on the products of human plasma fractionation. XXXVI. Inactivation of the virus of homologous serum hepatitis in solutions of normal human serum albumin by means of heat. J Clin Invest, 1948; 27: 239–44.
Scatchard G, Gibson ST, Woodruff LM, Batchelder AC, Brown A: Chemical, clinical, and immunological studies on the products of human plasma fractionation. IV. A study of the thermal stability of human serum albumin. J Clin Invest, 1944; 23: 445–53.
Heimburger N, Schwinn H, Gratz P, Lüben G, Kumpe G, Herchenhan B: Faktor VIII-Konzentrat, hochgereinigt and in Lösung erhitzt. Arzneim-Forsch, 1981; 31: 619–22.
Fernandes PM, Lundblad JL: Pasteurized therapeutically active protein compositions. Eur Pat Appl, 1980; 35: 204.
Dolana G, Tse D, Thomas W, Kingdon HS: Hepatitis risk reduction in hemophilia; a heated factor VIII preparation. Blood, 1982; 60: (suppl. 1), 768 (abstract).
Tabor E, Aronson DL, Gerety RJ: Removal of hepatitisB-virus infectivity from factor-IX complex by hepatitis-B immuneglobulin. Lancet, 1980; 2: 68–70.
Brummelhuis HGJ, Over J, Duivis-Vorst CC, Wilson-de Sturler LA, Ates G, Hoek PJ, Reerink-Brongers EE: Contribution to the optimal use of human blood. IX. Elimination of hepatitis B transmission by (potentially) infectious plasma derivatives. Vox Sang, 1983; 45: 205–16.
Prince AM, Stephan W, Brotman B: ß-propiolactone/ultraviolet irradiation: a review of its effectiveness for inactivation of viruses in blood derivatives. Rev Infect Dis, 1983; 5: 92–107.
Prince AM, Stephan W, Brotman B, van den Ende MC: Evaluation of the effect of betapropiolactone/ultraviolet irradiation (BPL/UV) treatment of source plasma on hepatitis transmission by factor IX complex in chimpanzees. Thromb Haemost, 1980; 44: 138–42.
Newman J, Johnson AJ, Karpatkin MH, Puszkin S: Methods for the production of clinically effective intermediate-and high-purity factor-VIII concentrates. Br J Haematol, 1971; 21: 1–20.
Weinstein M, Deykin D: Comparison of factor VIII-related von Willebrand factor proteins prepared from human cryoprecipitate and factor VIII concentrate. Blood, 1979; 53: 1095–1105.
Janson PA, Jubelirer SJ, Weinstein MJ, Deykin D: Treatment of the bleeding tendency in uremia with cryoprecipitate. N Engl J Med, 1980; 303: 1318–22.
Kasper CK: Thromboembolic complications. Thromb Diath Haemorrh, 1975; 33: 640–44.
Kingdon HS, Lundblad RL, Veltkamp JJ, Aronson DL: Potentially thrombogenic materials in factor IX concentrates. Thromb Diath Haemorrh, 1975; 33: 617–31.
Giles AR, Nesheim ME, Hoogendoorn H, Tracy PB, Mann KG: The coagulant-active phospholipid content is a major determinant of in vivo thrombogenicity of prothrombin complex (factor IX) concentrates in rabbits. Blood, 1982; 59: 401–7.
Magner A, Aronson DL: Toxicity of factor IX concentrates in mice. Develop Biol Stand, 1979; 44: 185–88.
Dike GWR, Griffiths D, Bidwell E, Snape TJ, Rizza CR: A factor VII concentrate for therapeutic use. Br J Haematol, 1980; 45: 107–18.
Kosow DP, Behre HE, Orthner CL, Menache D: Preparation and properties of a factor IX concentrate depleted of prothrombin and factor X. Thromb Haemost, 1983; 50: 116 (abstract).
Hultin MB: Activated clotting factors in factor IX concentrates. Blood, 1979; 54: 1028–38.
Seligsohn U, Kasper CK, Osterud B, Rapaport SI: Activated factor VII: presence in factor IX concentrates and persistence in the circulation after infusion. Blood, 1979; 53: 828–37.
Sjamsoedin UM, Heijnen L, Mauser-Bunschoten EP, van Geijlswijk JL, van Houwelingen H, van Asten P, Sixma JJ: The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII. A double-blind clinical trial. N Engl J Med, 1981; 305: 717–21.
Lusher JM, Shapiro SS, Palascak JE, Rao AV, Levine PH, Blatt PM and the hemophilia study group: Efficacy of prothrombin-complex concentrates in hemophiliacs with antibodies to factor VIII. A multicenter therapeutic trial. N Engl J Med, 1980; 303: 421–25.
Stenflo J: A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization. J Biol Chem, 1976; 251: 355–63.
Kisiel W: Human plasma protein C. Isolation, characterization, and mechanism of activation by α-thrombin. J Clin Invest, 1979; 64: 761–69.
Opie EL, Barker BI: Leucoprotease and anti-leucoprotease of mammals and of birds. J Exp Med, 1907; 9: 20721.
Aoki N, Saito H, Kamiya T, Koie K, Sakata Y, Kobakura M: Congenital deficiency of α2-plasmin inhibitor associated with severe hemorrhagic tendency. J Clin Invest, 1979; 63: 877–84.
Sharp HL, Bridges RA, Krivit W, Freier EF: Cirrhosis associated with alpha-l-antitrypsin deficiency: a previously unrecognized inherited disorder. J Lab Clin Med, 1969; 73: 934–39.
Laurell CB, Eriksson S: The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. Scand J Clin Lab Invest, 1963; 15: 132–40.
Vogelaar EF, Brummelhuis HGJ, Krijnen HW: Contributions to the optimal use of human blood. III. Large-scale preparation of human Cl esterase inhibitor concentrate for clinical use. Vox Sang, 1974; 26: 118–27.
van der Starre P, Sinclair D, Damen J, Brummelhuis H: Inhibition of the hypotensive effect of plasma protein solutions by C1esterase inhibitor. J Thorac Cardiovasc Surg, 1980; 79: 738–40.
Egeberg O: Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh, 1965; 13: 516–30.
Thaler E, Lechner K: Antithrombin III and thromboembolism. Clin Haematol, 1981; 10: 369–90.
Mannucci PM, Boyer C, Wolf M, Tripodi A, Larrieu MJ: Treatment of congenital antithrombin III deficiency with concentrates. Br J Haematol, 1982; 50: 531–35.
Brandt P: Observations during the treatment of antithrombin-III deficient women with heparin and antithrombin concentrate during pregnancy, parturition, and abortion. Thromb Res, 1981; 22: 15–24.
Jespersen J, Rasmussen NR, Toftgaard C: Observations during the treatment with antithrombin-III concentrate of a case of tampon-related toxic shock syndrome and disseminated intravascular coagulation. Discrepancies between functional and immunologic determinations of antithrombin. Thromb Res, 1982; 26: 457–62.
Laursen B, Mortensen JZ, Frost L, Hansen KB: Disseminated intravascular coagulation in hepatic failure treated with antithrombin III. Thromb Res, 1981; 22: 701–4.
Schipper HG, ten Cate JW: Antithrombin III transfusion in patients with hepatic cirrhosis. Br J Haematol, 1982; 52: 25–33.
Blauhut B, Necek S, Vinazzer H, Bergmann H: Substitution therapy with an antithrombin III concentrate in shock and DIC. Thromb Res, 1982; 27: 271–78.
Haak HL, Stolk JC, Gratama JW, van Hulsteyn H, Briet E: Use of antithrombin III concentrate in stable diffuse intravascular coagulation. A case report. Acta Haematol, 1982; 68: 28–33.
Kakkar VV: The clinical use of anti-thrombin III. Thromb Haemost, 1979; 42: 265 (abstract).
Alving BM, Hojima Y, Pisano JJ, Mason BL, Buckingham RE Jr, Mozen MM, Finlayson JS: Hypotension associated with prekallikrein activator (Hageman-factor fragments) in plasma protein fraction. N Engl J Med, 1978; 299: 66–70.
Heinonen J, Peltola K, Himberg JJ, Suomela H: Correlation of hypotensive effect of plasma protein fraction with prekallikrein activator activity: a clinical study in patients having openheart surgery. Ann Thorac Surg, 1982; 33: 24449.
van Rosevelt RF, Bakker JC, Sinclair DM, Damen J, van Mourik JA: Bradykinin-mediated hypotension after infusion of plasma-protein fraction. J Lab Clin Med, 1982; 100: 288–95.
Finlayson JS: Albumin products. Sem Thromb Hemost, 1980; 6: 85–120.
Finlayson JS: Immune globulins. Sem Thromb Hemost, 1979; 6: 44–74.
Bowman JM, Chown B, Lewis M, Pollock JM: Rh isoimmunization during pregnancy: antenatal prophylaxis. Can Med Assoc J, 1978; 118: 623–27.
Beasley RP, Hwang LY, Lin CC, Stevens CE, Wang KY, Sun TS, Hsieh FJ, Szmuness W: Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Initial report of a randomised double-blind placebo-controlled trial. Lancet, 1981; 2: 388–93.
Finlayson JS: Immune globulins with special reference to their role in bacterial and viral infections. In: Medical Microbiology, vol 1., Easmon CSF, Jeljaszewicz J (eds). Academic Press, London, 1982: 129–82.
Schultze HE, Schwick G: Über neue Möglichkeiten intravenöser Gammaglobulin-Applikation. Dtsch Med Wschr, 1962; 87: 1643–50.
Alving BM, Finlayson JS (eds): Immunglobulins: Characteristics and Uses of Intravenous Preparations. DHHS Publication No. (FDA)-80–9005, U.S. Government Printing Office, Washington, 1980.
Römer J, Morgenthaler JJ, Scherz R, Skvaril F: Characterization of various immunoglobulin preparations for intravenous application. I. Protein composition and antibody content. Vox Sang, 1982; 42: 62–73.
Nolte MT, Pirofsky B, Gerritz GA, Golding B: Intravenous immunoglobulin therapy for antibody deficiency. Clin Exp Immunol, 1979; 36: 237–43.
Ammann AJ, Ashman RF, Buckley RH, Hardie WR, Krantmann HJ, Nelson J, Ochs H, Stiehm ER, Tiller T, Wara DW, Wedgwood R: Use of intravenous γ-globulin in antibody immunodeficiency: results of a multicenter controlled trial. Clin Immunol Immunopathol, 1982; 22: 60–67.
Cunningham-Rundles C, Smithwick EM, Siegal FP, Day NK, Cunningham-Rundles S, Koziner B, Lion A, Barandun S, O’Malley J, Good RA: Treatment of primary humoral immunodeficiency disease with intravenous (pH 4.0 treated) gammaglobulin. In: Immunohemotherapy. A Guide to Immunoglobulin Prophylaxis and Therapy, Nydegger UE (ed). Academic Press, London, 1981: 283–90.
Duswald KH, Müller K, Seifert J, Ring J: Wirksamkeit von i.v. Gammaglobulin gegen bakterielle Infektionen chirurgischer Patienten. Ergebnisse einer kontrollierten, randomisierten klinischen Studie. Munch Med Wschr, 1980; 122: 832–36.
Kornhuber B: Administration of intravenous immunoglobulin to children with malignant diseases. In: Immunoglobulins: Characteristics and Uses of Intravenous Preparations, Alving BM, Finlayson JS (eds). DHHS Publication No. (FDA)-80–9005, U.S. Government Printing Office, Washington, 1980: 107–10.
Condie RM, Hall BL, Howard RJ, Fryd D, Simmons RL, Najarian JS: Treatment of life-threatening infections in renal transplant recipients with high-dose intravenous human IgG. Transplant Proc, 1979; 11: 66–68.
Winston DJ, Ho WG, Rasmussen LE, Lin CH, Chu CL, Merigan TC, Gale RP: Use of intravenous immune globulin in patients receiving bone marrow transplants. J Clin Immunol, 1982; 2: 42S - 47S.
Imbach P, Barandun S, d’Apuzzo V, Baumgartner C, Hirt A, Morell A, Rossi E, Schöni M, Vest M, Wagner HP: High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet, 1981; 1: 1228–31.
Fehr J, Hofmann V, Kappeler U: Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin. N Engl J Med, 1982; 306: 1254–58.
Pirofsky B: Which is the factual basis, in theory and clinical practice, for the use of intravenous gammaglobulin in the treatment of severe bacterial infections? Vox Sang, 1979; 37: 126–28.
Köhler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 1975; 256: 495–97.
Olsson L, Kaplan HS: Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity. Proc Natl Acad Sci USA, 1980; 77: 5429–31.
Croce CM, Linnenbach A, Hall W, Steplewski Z, Koprowski H: Production of human hybridomas secreting antibodies to measles virus. Nature, 1980; 288: 488–89.
Smith TW, Butler VP Jr, Haber E, Fozzard H, Marcus FI, Bremner WF, Schulman IC, Phillips A: Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Experience in 26 cases. N Engl J Med, 1982; 307: 1357–62.
Miller RA, Maloney DG, Warnke R, Levy R: Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N Engl J Med, 1982; 306: 517–22.
Cohen S, Pick E, Oppenheim JJ (eds): Biology of the Lymphokines. Academic Press, New York, 1979.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishers. Boston/Dordrecht/Lancaster
About this chapter
Cite this chapter
Aronson, D.L., Finlayson, J.S. (1985). Plasma proteins for therapeutic use: past, present and future. In: Das, P.C., Sibinga, C.T.S., Halie, M.R. (eds) Supportive therapy in haematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2577-2_7
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2577-2_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9617-1
Online ISBN: 978-1-4613-2577-2
eBook Packages: Springer Book Archive