Renal biopsies: glomerular subcellular features

  • Silvia Casanova
  • Renzo Laschi
Part of the Developments in Nephrology book series (DINE, volume 8)


Electron microscopy is nowadays a routine method in the study of renal biopsies. The doubts existing some years ago about the true validity of such a method, which was considered too sophisticated and too expensive, are now definitively overcome by the accurate analysis of the cost/benefit ratio.


Foam Interferon Fibril Proteinuria Collagenase 


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  1. 1.
    Haynes VDG: The normal human renal glomerulus. Virchows Arch (Cell Pathol) 35: 133–158, 1981.CrossRefGoogle Scholar
  2. 2.
    Grimley PM, Barry DW, Schaff Z: Induction of tubular structures in the endoplasmic reticulum of human lymphoblastoid cells by treatment with 5-bromo-2’deoxyuridine. J Natl Cancer Inst 51: 1751–1755, 1973.PubMedGoogle Scholar
  3. 3.
    Steffes MW, Barbosa J, Basgen J, Sutherland DER, Najarian JS, Mauer SM: Quantitative glomerular morphology of normal human kidney. Lab Invest 49: 82–86,1983.PubMedGoogle Scholar
  4. 4.
    Martinez-Hernandez A, Amenta PS: The basement membrane in pathology. Lab Invest 48: 656–677, 1983.PubMedGoogle Scholar
  5. 5.
    Thompson NM, Holdsworth SR, Glasgow EF, Atkins RC: The mac rophage in the development of experimental glomerulonephritis. Am J Path 94: 223–240,1979.Google Scholar
  6. 6.
    Parthasarathy N, Spiro RG: Effect of diabetes on the glycosamino glycan component of the human glomerular basement membrane. Diabetes 31: 738, 1982.PubMedCrossRefGoogle Scholar
  7. 7.
    Habib R, Gubler MC, Hinglais N, Noël LH, Droz D, Levy M, Mahieu P, Foidart JM, Perrin D, Bois E, Grunfeld JP: Alport’s syndrome: experience at Hospital Necker. Kidney Int 21: S20–S28, 1982.CrossRefGoogle Scholar
  8. 8.
    Hill GS, Jcnis EM, Goodloe S: The nonspecificity of ultrastructural alteration in hereditary nephritis. Lab Invest 31: 516–532, 1974.PubMedGoogle Scholar
  9. 9.
    Spear GS: Alport’s syndrome: A consideration of pathogenesis. Clin Nephrol 1: 336–337, 1973.PubMedGoogle Scholar
  10. 10.
    Olson DL, Anoud SK, Landin BH, Heuser E, Grushkin CM, Lieberman E: Diagnosis of hereditary nephritis by failure of glomeruli to bindanti-glomerular basement membrane antibodies. Pediatrics 96: 697–699, 1980.CrossRefGoogle Scholar
  11. 11.
    Magil A, Chase W. Frohlich J: Unusual biopsy findings in a patient with familial lecithin-cholesterol acyltransferase deficiency. Hum Pathol 13: 283–285, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Hoyer JR, Michael AF, Vernier RL: Renal disease in nail-patella syndrome. Clinical and morphological studies. Kidney Int 2: 231–238 1972.PubMedCrossRefGoogle Scholar
  13. 13.
    Törnroth T: The fate of subepithelial deposits in acute poststreptococcal glomerulonephritis. Lab Invest 35: 461–474, 1976.PubMedGoogle Scholar
  14. 14.
    Hinglais N, Garcia-Torres R, Kleinknecht D: Long-term prognosis in acute glomerulonephritis. The predictive value of early clinical and pathologic features observed in 65 patients. Am J Med 56: 52–60,1974.PubMedCrossRefGoogle Scholar
  15. 15.
    Strife CG, McEnery PT, Mac Adams AJ, West CD: Mem branoproliferative glomerulonephritis with disruption of the glomeru lar basement membrane. Clin Nephrol 7: 65–72, 1977.PubMedGoogle Scholar
  16. 16.
    Preud’Homme JL, Mihaesco E, Guglielmi P, Morel-Maroger L, Gancval D, Danon F, Brouet JC, Miahesco CM, Seligmann M: La maladie des dépôts de channes lîgères ou d’immunoglobulines monoclonales: concepts physiopathogèniques. Nouv Presse Med 11: 3259–3263,1982.PubMedGoogle Scholar
  17. 17.
    Kim Y, Vernier RL, Fish AJ, Michael AF: Immunofluorescence studies of dense deposits disease. The presence of railroad tracks and mesangial rings. Lab Invest 40: 474–480, 1979.PubMedGoogle Scholar
  18. 18.
    Droz D, Noël LH, Nabarra B, Leibovitch: The dense deposits disease of the renal basement membranes. Renal Physiol 3: 415–417, 1980.Google Scholar
  19. 19.
    Feiner H. Gallo G: Ultrastructure in glomerulonephritis associated with cryoglobulinemia: a report of six cases and review of the literature. Am J Pathol 88: 145–162, 1977.PubMedGoogle Scholar
  20. 20.
    Dikman SH, Churg J. Kahn T: Morphologic and clinical correlates in renal amyloidosis. Hum Pathol 12: 160–169, 1981.PubMedCrossRefGoogle Scholar
  21. 21.
    Hsu H-C, Churg J: Goomerular microfibrils in renal disease: A comparative electron microscopic study. Kidney Int 16: 497–504. 1979.PubMedCrossRefGoogle Scholar
  22. 22.
    Pak Poy RKF: Electron microscopy of amphibian renal glomerulus.Austr J Exp Biol Med Sci 35: 583–593, 1957.CrossRefGoogle Scholar
  23. 23.
    Zucchelli P, Casanova S., Sasdelli M, Cagnoli L, Pasquali S: Correlation of proteinuria and ultrastructural glomerular changes in toxaemia of pregnancy. In: Functional ultrastructure of the kidney. Maunsbach AB, Olsen TS, Christensen EI (eds) Academic Press New York, 1980, pp 151–161.Google Scholar
  24. 24.
    Seefeldt T, Bohman O. J∅rgcn HJ, Gundersen G, Maunsbach AB, Posborg Petersen V, Olsen TS: Quantitative relationship betweenglomerular foot process width and proteinuria in glomerulonephritis.Lab Invest 44: 541–546, 1981.PubMedGoogle Scholar
  25. 25.
    Kanwar JS, Rosenzweig LJ, Jabubowski ML: Distribution of the novo synthesized sulfated glycosaminoglycans in the glomerular basement membrane and mesangial matrix. Lab Invest 49: 216–225, 1983.PubMedGoogle Scholar

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© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Silvia Casanova
  • Renzo Laschi

There are no affiliations available

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