Pathophsiology of Coronary Artery Disease in Humans

  • Peter F. Cohn
  • Pantel S. Vokonas


The clinical presentation of coronary artery disease is familiar to most physicians, but the pathophysiologic basis of myocardial ischemia in humans—with its relevant therapeutic implications—has become evident only within the last two decades. There had once been almost no hemodynamic or metabolic information regarding mechanisms of the anginal state in humans, for example, but now there are a great number of such studies in the medical literature. To these have been added new investigations of the coronary circulation. The purpose of the present chapter is to review the important pathoanatomic and pathophysiologic features of coronary artery disease in humans and to relate them to the clinical setting whenever possible.


Coronary Artery Disease Myocardial Ischemia Angina Pectoris Myocardial Blood Flow Coronary Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Peter F. Cohn
  • Pantel S. Vokonas

There are no affiliations available

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