Summary
Human oncogenes homologous to v-fes, v-myb, v-myc, and v-sis have been cloned in recombinant phage vectors. Their structures have been elucidated by restriction enzyme and heteroduplex analyses, and in the case of c-sis by nucleotide sequencing as well. The complexity of these human genomic sequences is greater than that of the retroviral oncogenes, including multiple intervening sequences. In the cases of c-myb, c-myc, and c-sis, additional exons have been found by hybridization to mRNA or cDNA samples, compared to those characterized by hybridization to the retroviral oncogenes. In addition, a cDNA-containing plasmid with sequences of human c-sis mRNA has been isolated which can transform 3T3 fibroblasts. By somatic cell hybrid analysis and in situ hybridization, the chromosomal location of each of these oncogene homologues was determined, and compared to the chromosomal breakpoints in translocations in specific malignancies.
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References
Maniatis, T., Madison, P.C., Lacy, E., Lauer, J., O’Connell, C., Quon, D., Sin, G.K. and Esfratiadis, A. Cell 15:687–701, 1978.
Maniatis, T., Fritsch, E.F. and Sambrook, J. Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, 1982.
Okayama, H. and Berg, P. Mol. Cell. Biol. 2:161–170, 1982.
Gardner, M.B., Rongey, R.W., Anstein, P. Estes, J.D., Sarma, P., Huebner, R.J. and Richard, G. G. Nature 226:807–809, 1970.
McDonough, S.K., Larsen, S., Brodey, R.S., Stock, N.D. and Hardy, W.D., Jr. Cancer Res. 31:953–956, 1971.
Snyder, S.P. and Theilen, G.H. Nature 221:1074–1075, 1969.
Frankel, A.C., Gilbert, J.H., Porzig, K.J., Scolnick, E.M. and Aaronson, S.A. J. Virol. 20:821–827, 1979.
Shibuya, M., Hanafusa, T., Hanafusa, H. and Stephenson, J.R. Proc. Natl. Acad. Sci. USA 77:6536–6540, 1980.
Franchini, G., Gelmann, E.P., Dalla Favera, R., Gallo, R.C. and Wong-Staal, F. Mol. Cell. Biol. 2:1014–1019, 1982.
Franchini, G., Even, J., Scherr, C.J. and Wong-Staal, F. Nature 290:154–157, 1981.
Scherr, C.J., Fedele, L.A., Oskarsson, M., Maizel, J., Vande Woude, G.F. J. Virol. 34: 200–202, 1980.
Van Beveren, C., Galleshaw, J.A., Jonas, V., Berns, A.J.M., Doolittle, R., Donoghue, D.J. and Verma, I.M. Nature 289:258–262, 1981.
Goff, S.P., Gilboa, E., Witte, O.N. and Baltimore, D. Cell 22:777–785, 1980.
Takeya, T. and Hanafusa, H. Cell 22:881–890, 1983.
Chen, I.S.Y., Wilhelmsen, K.C. and Temin, H.M. J. Virol. 45:104–113, 1983.
Dhar, I.R., Ellis, R.W., Oroszlan, S., Shapiro, B., Maizel, J., Lowy, D. and Scolnick, E. Science 217:934–936, 1982.
Capon, D.J., Chen, E.Y., Levinson, A.D., Seeburg, D.H. and Goeddel, D.V. Nature 302:33–37, 1983.
Ellis, A.W., Lowy, D.R. and Scolnick, E.M. In: Advances in Viral Oncology (Ed. G. Klein), Raven Press, New York, 1982, Vol. 1, pp. 107–126.
Dalla Favera, R., Franchini, G., Martinotti, S., Wong-Staal, F., Gallo, R.C. and Croce, C.M. Proc. Natl. Acad. Sci. USA 79:4714–4717, 1980.
Heisterkamp, N., Groffen, J., Stephenson, J.R., Spurr, N.K., Goodfellow, P.N., Solomon, E., Carritt, B. and Bodmer, W.F. Nature 299:747–750, 1982.
Harper, M.E., Franchini, G., Love, J., Simon, M.I., Gallo, R.C. and Wong-Staal, F. Nature 304:169–171, 1983.
Rowley, J.D., Golomb, H.M. and Doughterty, C. Lancet i: 549–550, 1977.
Graf, T. and Beug, H. Biochim. Biophys. Acta. 516:269–299, 1978.
Rushlow, K.M., Lautenberger, J.A., Papas, T.S., Baluda, M.A., Perbal, B., Chirikjian, J.G. and Reddy, E.P. Science 216:1421–1423, 1982.
Franchini, G., Wong-Staal, F., Baluda, M.A., Lengel, C. and Tronick, S.R. Proc. Natl. Acad. Sci. USA 80:7385–7389, 1983.
3rd International Workshop on Chromosomes in Leukemia. Cancer Res. 42:868–873, 1983.
Westin, E.H., Gallo, R.C., Arya, S.K., Eva, A., Souza, L.M., Baluda, M.A., Aaronson, S.A. and Wong-Staal, F. Proc. Natl. Acad. Sci. USA 29:2194–2198, 1982.
Wake, N., Hreshchyshyn, M.M., Piver, S.M., Matsui, S. and Sandberg, A.A. Cancer Res. 40:4512–4518, 1980.
Trent, J.M. and Salmon, S.E. Cancer Genet. Cytogenet. 2:279–291, 1981.
Mitelman, F. and Levan, G. Hereditas 95:79–139, 1981.
Hann, S.R., Abrams, H.D., Rohrscheider, L.R. and Eisenman, R.N. Cell 21:789–798, 1983.
Dalla Favera, R., Gelmann, E.P., Martinotti, S., Franchini, G., Papas, T.S., Gallo, R.C. and Wong-Staal, F. Proc. Natl. Acad. Sci. USA 79:6497–6501, 1982.
Watt, R., Stanton, L.W., Marcu, K.B., Gallo, R.C., Croce, C.M. and Rovera, G. Nature 303:725–728, 1983.
Saito, H., Hayday, A.C., Wiman, K., Hayward, W.S. andTonegawa, S. Proc. Natl. Acad. Sci. USA 80:7476–7480, 1980.
Stanton, L.W., Watt, R. and Marcu, K. Nature 303:401–406, 1983.
Kohl, N.E., Kanda, N., Schreck, R.R., Bruns, G. Latt, S.A., Gilbert, F. and Alt, F.W. Cell 35:359–367, 1983.
Dalla Favera, R., Brogni, M., Erikson, J., Patterson, D., Gallo, R.C. and Croce, CM. Proc. Natl. Acad. Sci. USA 79:7824–7827, 1982.
Rabbitts,T.H., Forster, A., Baer, R. and Hamlyn, P.H. Nature 306:806–809, 1983.
Croce, C.M., Thierfelder, W., Erikson, J., Nishikura, K., Finan, J., Lenoir, G. and Nowell, C. Proc. Natl. Acad. Sci. USA 80: 6922–6926, 1983.
Erikson, J., Nishikura, K., Ar-Rushdi, A., Finan, J., Emanuel, B., Lenoir, G., Nowell, P.C. and Croce, C.M. Proc. Natl. Acad. Sci. USA 80:7581–7585, 1983.
Hollis, C.F., Mitchell, K.F., Battey, J., Potter, H., Taub, R., Lenoir, C.M. and Leder, P. Nature 307:752–755, 1984.
Gelmann, E.P., Psallidopoulos, M.C., Papas, T.S. and Dalla Favera, R. Nature 306:799–803, 1983.
Rabbitts, T.H., Hamlyn, P.H. and Baer, R. Nature 306: 760–768, 1983.
Battey, J., Moulding, C., Taub, R., Murphy, W., Stewart, T., Potter, H., Lenoir, G. and Leder, P. Cell 34:799–789, 1983.
Hamlyn, P.H. and Rabbitts, T.H. Nature 304:135–139, 1983.
Erikson, J., Ar-Rushi, A., Drwinga, H.L., Nowell, P.C. and Croce, C.M. Proc. Natl. Acad. Sci. USA 80:820–824, 1983.
Klein, G. Nature 294:313–318, 1981.
Nishikura, K., Ar-Rushdi, A., Erikson, J., Watt, R., Rovera, G. and Croce, C.M. Proc. Natl. Acad. Sci. USA 80:4822–4826, 1983.
Shen-Ong, G.L.C., Keath, E.J., Piccoli, S.P. and Cole, M.D. Cell 31:443–452, 1982.
Adams, J.M., Gerondakis, S., Webb, E., Mitchell, J., Bernard, O. and Cory, S. Proc. Natl. Acad. Sci. USA 7:6966–6970, 1982.
Wiener, F., Onno, S., Babonitz, M., Sumegi, J., Wirschubsky, Z., Klein, G., Mushinski, J.F. and Potter, M. Proc. Natl. Acad. Sci. USA 81:1159–1163, 1984.
Calame, K., Kim, S., Lalley, P., Hill, R., Davis, S. and Hood, L. Proc. Natl. Acad. Sci. USA 79:6994–6998, 1982.
Taub, R., Hirsch, I., Morton, C., Lenoir, G., Swan, D., Tronick, S., Aaronson, S. and Leder, P. Proc. Natl. Acad. Sci. USA 79:7837–7841, 1982.
Theilen, G.H., Gould, D., Fowler, M. and Dungworth, D.L. J. Natl. Cancer Inst. 47:88l-889, 1971.
Gelmann, E.P., Wong-Staal, F., Kramer, R.A. and Gallo, R.C. Proc. Natl. Acad. Sci. USA 78:3373–3377, 1981.
Robbins, K.C., Devare, S.G. and Aaronson, S.A. Proc. Natl. Acad. Sci. USA 78: 2918–2922, 1981.
Gelmann, E.P., Petri, B., Cetta, A. and Wong-Staal, F. J. Virol. 41:593–604, 1982.
Wong-Staal, F., Dalla Favera, R., Gelmann, E.P., Manzari, V., Szala, S., Josephs, S.F. and Gallo, R.C. Nature 294:273–275, 1981.
Devare, S.G., Reddy, E.P., Law, D.J., Robbins, K.C. and Aaronson, S.A. Proc. Natl. Acad. Sci. USA 80:731–735, 1983.
Robbins, K.C., Antoniades, H.N., Devare, S.G., Hunkapiller M.W. and Aaronson, S.A. Nature 305:605–608, 1983.
Doolittle, R.F., Hunkapiller, M.W., Hood, L.E., Devare, S.G., Robbins, K.C., Aaronson, S.A. and Antoniades, H. Science 221:275–277, 1983.
Waterfield, M.D., Scrace, G.T., Stroobant, P., Wasteson, A., Westermark, B., Helden, C-H., Huang, J.S. and Deuel, T.F. Nature 304:35–39, 1983.
Deuel, T.F., Huang, J.S., Proffitt, R.T., Chang, D. and Kennedy, B.B. J. Supramolec. Struct. Cell Biochem. Suppl. 5:128, 1981.
Deuel, T.F., Huang, J.S., Proffitt, R.T., Baenziger, J.U., Chang, D. and Kennedy, B.B. J. Biol. Chem. 256: 8896–8899, 1981.
Johnsson, A., Heldin, C-H., Westermark, B. and Wasteson, A. Biochem. Biophys. Res. Commun. 104:66–74, 1982.
Antoniades, H.N. and Hunkapiller, M.W. Science 220:963–965, 1983.
Dalla Favera, R., Gelmann, E.P., Gallo, R.C. and Wong-Staal, F. Nature 292:31–35, 1981.
Josephs, S.F., Guo, C., Ratner, L. and Wong-Staal, F. Science 223:487–491, 1984.
Josephs, S.F., Dalla Favera, R., Gelmann, E.P., Gallo, R.C. and Wong-Staal, F. Science 219:503–505, 1983.
Dalla Favera, R., Gallo, R.C., Giallongo, A. and Croce, C.M. Science 218:686–688, 1982.
Swan, D.C., McBride, O.W., Robbins, K.C., Keithley, D.A., Reddy, E.P. and Aaronson, S.A. Proc. Natl. Acad. Sci. USA 29:4691–4695, 1982.
Bartram, C.R., deKlein, A., Hagemeijer, A., Grosveld, G., Heisterkamp, N. and Groffen, J. Blood 63:223–225, 1984.
deKlein, A., Geurts van Kessel, A., Grosveld, G., Bartram, C.R., Hagemeijer, A., Bootsma, D., Spurr, N.K., Heisterkamp, N., Groffen, J. and Stephenson, J.R. Nature 300:765–767, 1982.
Collins, S. and Groudine, M.T. Proc. Natl. Acad. Sci. USA 80:4813–4817, 1983.
Selden, J.R., Emanuel, B., Wong, E., Cannizzaro, L., Polumbo, A., Erikson, J., Nowell, P.C., Rovera, G. and Croce, C.M. Proc. Natl. Acad. Sci. USA 80:7289–7292, 1983.
Aurias, A., Rimbaut, C., Buffe, D., Dubosset, J. and Mazabraud, A. N. Engl. J. Med. 309:496–497, 1983.
Turc-Carel, C., Philip, I., Berger, M.P., Philip, T. and Lenoir, G.M. N. Engl. J. Med. 309:497–498, 1983.
Westin, E.H., Wong-Staal, F., Gelmann, E.P., Dalla Favera, R., Papas, T.S., Lautenberger, J.A., Eva, A., Reddy, E.P., Tronick, S.R., Aaronson, S.A. and Gallo, R.C. Proc. Natl. Acad. Sci. USA 79:2490–2494, 1982.
Eva, A., Robbins, K.C., Andersen, P.R., Srinivasan, A., Tronick, S.R., Reddy, E.P., Ellmore, N.W., Galen, A.T., Lautenberger, J.A., Papas, T.S., Westin, E.H., Wong-Staal, F., Gallo, R.C. and Aaronson, S.A. Nature 295; 116–119, 1982.
Dalla Favera, R., Wong-Staal, F. and Gallo, R.C. Nature 299:61–63, 1982.
Nowell, P., Finan, J., Dalla Favera, R., Gallo, R.C., Ar-Rushdi, A., Ramaczuk, H., Rovera, G. and Croce, C.M. Nature 306:494–497, 1983.
Little, C.D., Nau, M.M., Carney, D.N., Gazdar, A.F. and Mann, J.D. Nature 306:194–196, 1983.
Alitalo, K., Schwab, M., Lin, C.C., Varmus, H.E. and Bishop, J.M. Proc. Natl. Acad. Sci. USA 80:1707–1711, 1983.
Schwab, M., Alitalo, K., Varmus, H.E. and Bishop, J.M. Nature 303:497–501, 1983.
Clarke, M.F., Westin, E., Schmidt, D., Josephs, S.F., Ratner, L., Wong-Staal, F., Gallo, R.C. and Reitz, J.S., Jr. Nature 308:464–467, 1984.
Stiles, C.D. Cell 33:653–655, 1983.
Kelley, K., Cochran, B.H., Stiles, C.D. and Leder, P. Cell 35:603–610, 1983.
Land, H., Parada, L.F. and Weinberg, R.A. Nature 304: 596–602, 1983.
Shimizu, K., Birnbaum, D., Ruley, M.A., Fasano, O., Suard, Y., Edlund, L., Taparowsky, E., Goldfarb, M. and Wigler, M. Nature 304:497–500, 1983.
Nakano, H., Yamamoto, R., Neville, C., Evans, D., Mizuno, T. and Perucho, M. Proc. Natl. Acad. Sci. USA 81:71–75, 1984.
Tabin, C.J., Bradley, S.M., Bargmann, C.I., Weinberg, R.A., Papageorge, A.G., Scolnick, E.M., Dhar, R., Lowy, D.R. and Chang, E.H. Nature 300:143–149, 1982.
Reddy, E.P., Reynolds, R.K., Santos, E. and Barbacid, M. Nature 300:149–152, 1982.
Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M. and Wigler, M. Nature 300:762–765, 1982.
Capon, D.J., Seeburg, P.H., McGrath, J.P., Hayflick, J.S., Edman, U., Levinson, A.D. and Goeddel, D.V. Nature 304:507–513, 1983.
Taparowsky, E., Shimizu, K., Goldfarb, M. and Wigler, M. Cell 21:581–586, 1983.
Santos, E., Reddy, E.P., Pulciani, S., Feldmann, R.J. and Barbacid, M. Proc. Natl. Acad. Sci. USA 80:4679–4683, 1983.
Santos, E., Martin-Zanca, D., Reddy, E.P., Pierotti, M.A., Delia Porta, G. and Barbacid, M. Science 223:661–664, 1984.
Hayward, W.J., Neel, B.G. and Astrin, S.M. Nature 290: 475–480, 1981.
Neel, B.G., Hayward, W., Robinson, M.L., Fang, J. and Astrin, S.M. Cell 23:323–334, 1981.
Fung, Y.K., Faelly, A.M., Crittenden, L.B. and Kung, H.J. Proc. Natl. Acad. Sci. USA 78:3418–3422, 1981.
Payne, G.S., Bishop, J.M. and Varmus, M.E. Nature 295:209–214, 1982.
Fung, Y.K.T., Crittenden, L.B. and Kung, H.J. J. Virol. 44:742–746, 1982.
Noori-Dalooi, M.R., Swift, R.A., Kung, H.J., Witter, R.L. and Crittenden, L.B. Nature 294:574–576, 1981.
Vennstrom, B. and Bishop, J.M. Cell 28:135–143, 1982.
Fung, Y-K.T., Lewis, W.G., Crittenden, L.B. and Kung, H.J. Cell 33:357–368, 1983.
Blair, D.G., McClements, W.L., Oskarsson, M., Fischinger, P. and Vande Woude, G.F. Proc. Natl. Acad. Sci. USA 77:3504–3508, 1980.
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Ratner, L., Gallo, R.C., Wong-Staal, F. (1985). Cloning of Human Oncogenes. In: Becker, Y., Hadar, J. (eds) Recombinant DNA Research and Viruses. Developments in Molecular Virology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2565-9_2
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