The human tumor clonogenic assay used to study ovarian cancers

  • Charles E. Welander
Part of the Cancer Treatment and Research book series (CTAR, volume 23)

Abstract

During the last decade, the treatment of ovarian cancer has changed markedly as the available armamentarium of cytotoxic drugs has improved. It remains apparent that surgical cytoreduction (debulking) procedures are useful, particularly in those cases where the largest mass of residual tumor can be reduced to less than 1 cm in size [1]. However, even more important than the degree of surgical debulking which can be achieved is the apparent improvement in clinical response rates seen with new innovations in chemotherapy. The Gynecologic Oncology Group (GOG) conducted a large randomized trial between 1976 and 1979 of suboptimal (> 3 cm tumor bulk) untreated ovarian cancers (Protocol #22), which showed that melphalan alone was as effective as the combination of cyclophosphamide and doxorubicin in the observed response rates and survival durations [2]. However, the subsequent GOG Protocol # 47 showed that the addition of cisplatin to cyclophosphamide and doxorubicin improved response rates from 46% to 71% with the median duration of survival increasing from 9.5 months to 15.0 months [3]. The fact, however, becomes apparent that a. survival duration of 15 months is not a cure, and the good benefits which cisplatin bestowed on patients with ovarian cancers are limited. The empiric choice of chemotherapeutic agents does not necessarily provide maximal benefit to each patient with ovarian cancer.

Keywords

Oncol Interferon Doxorubicin Melphalan Cyclophosphamide 

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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • Charles E. Welander

There are no affiliations available

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