Restrictive and Infiltrative Cardiomyopathy

  • Robert J. Howard
  • Harry Rakowski


Restrictive cardiomyopathy is far less common in North America than the congestive and hypertrophic myopathies. The terms refers to a condition characterized by a ‘stiff heart’ due to rigid ventricular walls with impaired diastolic filling. Infiltration or fibrosis of the myocardium is the usual cause [1]. Hemodynamic studies demonstrate a characteristic dip and plateau configuration typical of diastolic dysfunction, while systolic function is often normal. All of the restrictive cardiomyopathies are infiltrative, however, the converse is not always true as not all infiltrative cardiomyopathies are primarily restrictive. The clinical and hemodynamic characteristics of infiltrative cardiomyopathies occupy a spectrum from the classic restrictive type to the purely congestive.


Cardiac Sarcoidosis Constrictive Pericarditis Cardiac Amyloidosis Hypereosinophilic Syndrome Progressive Systemic Sclerosis 
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  1. 1.
    Braunwald E: Heart Disease. A Textbook of Cardiovascular Medicine. WB Saunders, Philadelphia, London, Toronto. 1980, pp 1460–1472.Google Scholar
  2. 2.
    Hirschmann JV: Pericardial constriction. Amer Heart. J 96:110, 1978.PubMedCrossRefGoogle Scholar
  3. 3.
    Meany E, Shabetai R, Bhargava V, Shearer M, Weidner C, Mangiardi LH, Smalling R & Peterson K: Cardiac amyloidosis, constrictive pericarditis and restrictive cardiomyopathy. Amer J Cardiol 38:547, 1976.CrossRefGoogle Scholar
  4. 4.
    Schroeder JS, Billingham ME & Rider AK: Cardiac amyloidosis: Diagnosis by transvenous endomyocardial biopsy. Amer J Med 59:269–273, 1975.PubMedCrossRefGoogle Scholar
  5. 5.
    Lorell B, Alderman E & Mason JW: Cardiac sarcoidosis: Diagnosis with endomyocardial biopsy and treatment with corticosteroids. Amer J Cardiol 42:143–146, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Child JS, Levisman JA, Abbasi AS & McAlpin RN: Echo-cardiographic manifestations of infiltrative cardiomyopathy. Chest 70:726–731, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Child JS, Krivokapich J & Abbasi AS: Increased right ventricular wall thickness on echocardiography in amyloid infiltrative cardiomyopathy. Amer J Cardiol 44:1391–1395, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Borer JS, Henry WL & Epstein SE: Echocardiographic observations in patients with systemic infiltrative disease involving the heart. Amer J Cardiol 39:184–188, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Rakowski H, Boughner DR, Sole MJ & Wigle ED: The echocardiographic diagnosis of amyloid cardiomyopathy. Circulation 54:II-84, 1976 (abstract).Google Scholar
  10. 10.
    Siqueira-Filho AG, Cunha C, Tajik AJ, Seward JB, Schattenberg TT & Giuliani ER: M-mode and two-dimensional echocardiographic features in cardiac amyloidosis. Circulation 63:188–196, 1981.PubMedCrossRefGoogle Scholar
  11. 11.
    Chiaramida SA, Goldman MA, Zema MJ, Pizzarello RA & Goldberg HM: Real-time cross-sectional echocardiographic diagnosis of infiltrative cardiomyopathy due to amyloid. J Clin Ultrasound 8:58–62, 1980.PubMedCrossRefGoogle Scholar
  12. 12.
    Joynt L, Boyle D, Rakowski H, Popp R & Beaver B: Identification of tissue parameters by digital processing of real-time ultrasonic-clinical cardiac data. In: Linzer M (ed) Ultrasonic Tissue Characterization II. National Bureau of Standards, Spec Publ 525, 1979.Google Scholar
  13. 13.
    Meany E, Shabetai R, Bhargava V, Shearer M, Weidner C, Mangiardi LM, Smalling R & Peterson K: Cardiac amyloidosis, constrictive pericarditis and restrictive cardiomyopathy. Amer J Cardiol 38:547–556, 1976.CrossRefGoogle Scholar
  14. 14.
    Buja LM, Khoi NB & Roberts WC: Clinically significant amyloidosis: Clinicopathologic findings in 15 patients. Amer J Cardiol 26:394–405, 1970.PubMedCrossRefGoogle Scholar
  15. 15.
    Loeffler W: Endocarditis parietalis fibroplastica mit Bluteosineophile. Ein eigenartiges Krankheitsblid. Schweitz Med Wochenschr 66:817, 1936.Google Scholar
  16. 16.
    Chusid MJ, Dale DC, West BC & Wolff SM: The hypereosinophilic syndrome: Analysis of fourteen cases with review of the literature. Medicine 51:1, 1975.CrossRefGoogle Scholar
  17. 17.
    Parrillo JE, Borer JS, Henry WL, Wolff SM & Fauci As: The cardiovascular manifestations of the hypereosinophilic syndrome. Prospective study of 26 patients with review of the literature. Amer J Med 67:573, 1979.CrossRefGoogle Scholar
  18. 18.
    Olsen EG: Endomyocardial fibrosis and IÄfflers endocarditis parietalis fibroplatica. Postgrad Med J 53228, 1977.Google Scholar
  19. 19.
    Brockington IF & Olsen EGJ: Löffler’s endocarditis and Davies’ endomyocardial fibrosis. Amer Heart J 85:308, 1973.CrossRefGoogle Scholar
  20. 20.
    Puigbo JJ, Acquatella H, Schiller NB, Tortoledo F, Cornbellas I, Casal H, Giordano H & Hirschhant E: Two-dimensional echocardiographic findings in Endomyocardial Fibrosis. Circulation IV-48, 1981 (abstract).Google Scholar
  21. 21.
    Gottdiener JS, Schooley RT, Maron BJ & Fauci AS: Cardiac abnormality in the hypereosinophilic syndrome-Identification of a unique mechanism for mitral regurgitation by two-dimensional echocardiography. Circulation II-18, 1979 (abstract).Google Scholar
  22. 22.
    Davies JNP & Coles RM: Some considerations regarding obscure disease affecting the mural endocardium. Amer Heart J 59:606, 1960.CrossRefGoogle Scholar
  23. 23.
    Roberts WC, Buja LM & Ferrans VJ: Löffler’s fibroplastic parietal endocarditis, eosinophilic leukemia, and Davies’ endomyocardial fibrosis: the same disease at different stages? Pathol Microbiol 36:90–95, 1970.Google Scholar
  24. 24.
    Chew CYC, Ziady GM, Raphael MJ, Nellen M & Oakley CM: Primary restrictive cardiomyomyopathy. Non tropical endomyocardial fibrosis and hypereosinophilic heart disease. Brit Heart J 39:399–413, 1977.PubMedCrossRefGoogle Scholar
  25. 25.
    Hess OM, Turina M, Senning A, Goebel NH, Scholer Y & Krayenbuehl HP: Pre-and post-operative findings in patients with endomyocardial fibrosis. Brit Heart J 40:406–415, 1978.PubMedCrossRefGoogle Scholar
  26. 26.
    Buja LM & Roberts WC: Iron in the heart, etiology and clinical significance. Amer J Med 51:209, 1971.PubMedCrossRefGoogle Scholar
  27. 27.
    Henry WL, Nienhuis AW, Wiener M, Miller DR, Canale VC & Piomelli S: Echocardiographic abnormalities in patients with transfusion dependant anemia and secondary myocardial iron deposition. Amer J Med 64:647–555, 1978.CrossRefGoogle Scholar
  28. 28.
    Silverman KJ, Hutchins GM & Bulkley BH: Cardiac sarcoid: A clinicopathological study of 84 unselected patients with systemic sarcoidosis. Circulation 58604, 1978.Google Scholar
  29. 29.
    Roberts WC, McAllister HA & Ferrans VJ: Sarcoidosis of the heart. A clinicopathological study of 35 necropsy patients (Group 1) and review of 78 previously described necropsy patients (Group 2). Amer J Cardiol 63:86, 1977.Google Scholar
  30. 30.
    Lorell B, Alderman E & Mason JW: Cardiac sarcoidosis. Diagnosis with cardiomyocardial biopsy and treatment with corticosteroids. Amer J Cardiol 42:143–146, 1978.PubMedCrossRefGoogle Scholar
  31. 31.
    Bulkley BH, Ridolfi RL & Salyer WR: Myocardial lesions of progressive systemic sclerosis. Circulation 530, 1976.Google Scholar
  32. 32.
    Smith J, Clements PJ, Levisman J, Furst D & Ross M: Echocardiographic features of progressive systemic sclerosis (PSS). Correlation with hemodynamic and postmortem studies. Amer J Med 66:28–33, 1979.PubMedCrossRefGoogle Scholar
  33. 33.
    Gottdiener JS, Moutsopoulos HM & Decker JL: Echo-cardiographic identification of cardiac abnormality in scleroderma and related disorders. Amer J Med 66:391398, 1979.Google Scholar
  34. 34.
    Eggebrecht RF & Kleiger RE: Echocardiographic patterns in scleroderma. Chest 71à6–51, 1977.Google Scholar
  35. 35.
    Alexander E, Heuser R, Weiss JL, Firestein GS, Leitl G, Wagner HN, Stevens MB & Becker LC: Scleroderma heart disease: evidence for cold induced abnormalities of myocardial perfusion and function. Circulation 64:IV-24, 1981 (abstract).Google Scholar
  36. 36.
    Graham-Smith DG: The Carcinoid Syndrome. White Friars Press London, 1972, p 61.Google Scholar
  37. 37.
    Howard RJ, Drobac M, Rider WD, Keane Ti, Finlayson J, Silver MD, Wigle ED & Rakowski H: Carcinoid heart disease: Diagnosis by two-dimensional echocardiography. Circulation 66:1059–1065, 1982.PubMedCrossRefGoogle Scholar
  38. 38.
    Callahan JA, Wroblewski EM, Reeder GS, Edwards WD, Seward JB & Tajid AJ: Echocardiographic features of carcinoid heart disease. Amer J Cardiol 50:762–768, 1981.CrossRefGoogle Scholar
  39. 39.
    Roberts WC & Sjoerdsma A: The cardiac disease associated with the carcinoid syndrome (Carcinoid heart disease). Amer J Med 36:5, 1964.PubMedCrossRefGoogle Scholar

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© Martinus Nijhoff Publishing, Boston/Dordrecht/Lancaster 1985

Authors and Affiliations

  • Robert J. Howard
  • Harry Rakowski

There are no affiliations available

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