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Metabolic Interactions of Selenium with Cadmium, Mercury, and Silver

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Advances in Nutritional Research

Part of the book series: Advances in Nutritional Research ((ANUR,volume 7))

Abstract

Until the discovery of the essentiality of selenium by- Schwarz and Foltz (1957), the only physiological significance of this element was thought to be its toxicity. The finding that selenium could prevent dietary liver necrosis in rats resulted in a reassessment of this element. Interestingly, this same year the properties of a newly discovered enzyme, glutathione peroxidase (GSH-Px), were reproted (Mills, 1957). However, it took a decade and a half to discover that this enzyme has a relationship to selenium (Rotruck et al., 1973). GSH-Px has been shown to be a selenoenzyme, containing 4 g atoms of selenium/mole protein (Oh et al., 1974). Another equally important discovery was that selenium could counteract the toxicity of some heavy metals. Thus, this rather unusual feature of one element such as selenium, which is highly toxic itself at elevated levels, counteracting the toxicity of heavy metal stimulated intensive research on the relationship of selenium to other elements. The purpose of this review is to discuss some of the metabolic relationship of selenium to cadmium, mercury, and silver. A briefly discussion of some of these interactions has been presented previously (Ridlington and Whanger, 1981). Several reviews are available in the interactions of selenium with heavy metals, and these maybe useful for further reading (Parizek et al., 1971, 1974; Diplock, 1976; Rimerman et al., 1977; Whanger, 1981).

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  1. Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon, 97331, USA

    P. D. Whanger

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  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

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Whanger, P.D. (1985). Metabolic Interactions of Selenium with Cadmium, Mercury, and Silver. In: Draper, H.H. (eds) Advances in Nutritional Research. Advances in Nutritional Research, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2529-1_9

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