Fine Structure of Hereditary Defects of the Central Nervous System in Mice

  • Doris Burda Wilson

Abstract

Of all the laboratory animals that exhibit hereditary defects of the nervous system, the house mouse (Mus musculus) has proven to be one of the richest sources of material. Not only are there numerous inbred strains of mice, but the number and variety of neurological mutations continue to grow. The latter thus serve as useful models for analyzing comparable human disorders. In many instances it is not known whether the mutant condition in an animal represents a human defect until a thorough morphological and physiological study is made. Moreover, although some defects, such as exencephaly, are immediately obvious, others may first be detected only as a behavioral disturbance, such as ataxia. Still other neurological defects may not be at all obvious until various morphological and functional features of the nervous system are methodically observed and tested.

Keywords

Manganese Retina Neuropathy Luminal Neurol 

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Reference

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Doris Burda Wilson
    • 1
  1. 1.Division of Anatomy, Department of Surgery, School of MedicineUniversity of California at San DiegoCaliforniaUSA

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