Antibodies to DNA Epiphenomena or Pathogens?
The study of antibodies directed against DNA began in the 1950s with the discovery of the L.E. cell by Hargraves. Several investigators found that the L.E. cell phenomenon resulted from ingestion of altered nuclear material by circulating phagocytic cells. Close examination of that material showed that it consisted of DNA-protein (predominantly DNA-histone) and IgG. Thus, the existence of antibodies to the supposedly “forbidden” constituents of the human nucleus was recognized.
KeywordsSystemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Lupus Nephritis Glomerular Basement Membrane Active Systemic Lupus Erythematosus
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