Antibodies to DNA Epiphenomena or Pathogens?
The study of antibodies directed against DNA began in the 1950s with the discovery of the L.E. cell by Hargraves. Several investigators found that the L.E. cell phenomenon resulted from ingestion of altered nuclear material by circulating phagocytic cells. Close examination of that material showed that it consisted of DNA-protein (predominantly DNA-histone) and IgG. Thus, the existence of antibodies to the supposedly “forbidden” constituents of the human nucleus was recognized.
KeywordsTestosterone Androgen Proteinuria Nucleoside Cytosine
Unable to display preview. Download preview PDF.
- Adams, R. L. P. (ed.), 1976, Davidson’s The Biochemistry of the Nucleic Acids, Academic Press, New York.Google Scholar
- Alarcon-Segovia, D., 1975, Drug induced systemic lupus erythematosus and related syndromes, Clin. Rheum. Dis. 1: 573–592.Google Scholar
- Andrezejewski, C., Jr., Stollar, B. D., Lalor, T. M., and Schwartz, R. S., 1980, Hybridoma auto-antibodies to DNA, J. Immunol. 124: 1499–1503.Google Scholar
- Arnett, F. C., Jr., 1983, Systemic lupus erythematosus: Current state of the genetic hypothesis, in: Current Topics in Rheumatology ( B. H. Hahn, F. C. Arnett, T. M. Zizic, and M. C. Hochberg, eds.), The Upjohn Co., Kalamazoo, MI, pp. 1–160.Google Scholar
- Eschar, Z., Benecerraf, B., and Katz, D. H., 1975, Induction of tolerance to nucleic acid determinants by administration of a complex of nucleoside D-glutamic acid and D-lysine (D-GL), J. Immunol. 114: 872–876.Google Scholar
- Fries, J. F., and Holman, H. R., 1975, Systemic Lupus Erythematosus: A Clinical Analysis, W. B. Saunders, Philadelphia.Google Scholar
- Hahn, B. H., Sharp, G. C., Irvin, W. S., Kantor, O. S., Gardner, C. A., Bagby, M., Perry, H. M., Jr., and Osterland, C. K., 1972, Immune responses to hydralazine and nuclear antigens in hydralazine-induced lupus erythematosus, Am. J. Med. 76: 365–374.Google Scholar
- Izui, J., Lambert, P.-H., and Miescher, P. A., 1976, In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA, J. Exp. Med. 144: 428–443.Google Scholar
- Jarros, E. M., Gjaravo, N. E., and Hughes, G. R. V., 1983, Cardiolipin antibodies: Detection by radioimmunoassay and association with thrombosis in SLE, Lancet 2: 1211–1214.Google Scholar
- Jerne, N. K., 1971, Towards a network theory of the immune system, Ann. Immunol. 125C: 373–377.Google Scholar
- Roths, J. B., 1979, in: Genetic Control of Autoimmune Disease (N. R. Rose, P. E. Bigazzi, and N. L. Warner, eds.), Elsevier/North-Holland, New York, pp. 207–217.Google Scholar
- Schecter, Y., Maron, R., Elias, D., and Cohen, I. R., 1982, Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin, Science 216: 452–454.Google Scholar
- Seligmann, M., 1957, Mise en evidence dans le serum de malades atteints de lupus erythemateux dissemine d’une substance determinant une reaction de precipitation avec l’acide desoxyribonucleique, C. R. Acad. Sci. (D) (Paris) 245: 243–247.Google Scholar
- Talal, N., 1980, Tolerance and autoimmunity, in: Clinical Immunology ( C. P. Parker, ed.), W. B. Saunders, Philadelphia, pp. 105–109.Google Scholar
- Tan, E. M., 1976, Sunlight as a potential aetiological factor in systemic lupus erythematosus, in: Modern Topics in Rheumatology ( G. R. Hughes, ed.), Year Book Publishers, Chicago, pp. 99–106.Google Scholar