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Immunology of Rheumatic Diseases pp 221–235Cite as

Antibodies to DNA Epiphenomena or Pathogens?

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Abstract

The study of antibodies directed against DNA began in the 1950s with the discovery of the L.E. cell by Hargraves. Several investigators found that the L.E. cell phenomenon resulted from ingestion of altered nuclear material by circulating phagocytic cells. Close examination of that material showed that it consisted of DNA-protein (predominantly DNA-histone) and IgG. Thus, the existence of antibodies to the supposedly “forbidden” constituents of the human nucleus was recognized.

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Authors and Affiliations

  1. Department of Medicine, Division of Rheumatology, University of California, Los Angeles, California, 90024, USA

    Bevra H. Hahn

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  1. Bevra H. Hahn
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Editors and Affiliations

  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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© 1985 Plenum Publishing Corporation

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Hahn, B.H. (1985). Antibodies to DNA Epiphenomena or Pathogens?. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_8

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  • DOI: https://doi.org/10.1007/978-1-4613-2493-5_8

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