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Total Lymphoid Irradiation

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Immunology of Rheumatic Diseases

Abstract

There remains a great need in medicine for new immunosuppressive therapies that are capable of suppressing disease activity but are not associated with the complications of general cytotoxicity and nonselective immunosuppression. Currently available immunosuppressive drugs are too frequently associated with serious and sometimes lethal complications. We review here the relatively unique immunologic changes associated with total lymphoid irradiation (TLI) and the development of this form of radiotherapy as an immunosuppressive treatment for rheumatic diseases.

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Colorado Health Science Center, USA

    Brian L. Kotzin

  2. Rheumatology Section, Veteran Administration Medical Center, Denver, Colorado, 80220, USA

    Brian L. Kotzin

  3. Department of Medicine, Division of Immunology, Stanford University Medical Center, Stanford, California, 94305, USA

    Samuel Strober

Authors
  1. Brian L. Kotzin
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  2. Samuel Strober
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Editor information

Editors and Affiliations

  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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© 1985 Plenum Publishing Corporation

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Kotzin, B.L., Strober, S. (1985). Total Lymphoid Irradiation. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_30

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  • DOI: https://doi.org/10.1007/978-1-4613-2493-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9509-9

  • Online ISBN: 978-1-4613-2493-5

  • eBook Packages: Springer Book Archive

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