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Immunology of Rheumatic Diseases pp 727–739Cite as

Thymic Hormones and Rheumatoid Arthritis

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Abstract

T-cell differentiation proceeds under the command of several signals, among which thymic hormones (TH) play a central role. A number of T-cell abnormalities have been described in rheumatoid arthritis (RA), both by marker and functional studies. One may raise the question of thymic hormone production in RA and in related immunologic diseases such as systemic lupus erythematosus (SLE). Additionally, since thymic hormones can modulate T-cell functions, one may attempt to improve the clinical status of RA patients by using pharmacological doses of the hormones independently of a preexisting abnormality of thymic hormone production.

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References

  • Ahmed, A., Wong, D. M., Thurman, G. B., Low, T. L. K., and Goldstein, A. I., 1979, T-lymphocyte maturation cell surface markers and immune function, induced by T-lymphocyte cell free products and thymosin polypeptides,Ann. N.Y. Acad. Sci.332: 81–94.

    Article  PubMed  CAS  Google Scholar 

  • Amor, B., Dougados, M., Mery, C., de Gery, A., Choay, J., Dardenne, M., and Bach, J. F., 1984, Thymulin (FTS) in rheumatoid arthritis,Arthritis Rheum. 27:117–118.

    Article  PubMed  CAS  Google Scholar 

  • Auteri, A., Laghi Pasini, F., Pasque, A. L., Bilenchi, R., and Di Perri, T., 1980a, Azione della timopoietina pentapeptide sulla formazione di rosette lifocitarie E di pazienti affetti da artrite reumatoide I.Studio in vitro, Boll. Soc. Ital. Biol. Sper. 4:308–311.

    Google Scholar 

  • Auteri, A., Laghi Pasini, F., Pasqui, A. L., Bilenchi, R., and Di Perri, T., 1980b, Azione della timopoietina pentapeptide sulla formazione di rosette linfociatarie E di pazienti affetti da artrite reumatoide II. Studioin vivo Boll. Soc. Ital. Biol. Sper. 4:312–315.

    Google Scholar 

  • Bach, J. F., 1982, Thymic factors and immunoregulation role in autoimmune diseases, in:Regulation of the Immune Response( D. N. Jacobs and P. L. Ogra, eds.), Karger, Basel, pp. 20–29.

    Google Scholar 

  • Bach, J. F., 1983, Thymulin (FTS-Zn),Clin. Immunol. Allergy3: 133–157.

    CAS  Google Scholar 

  • Bach, J. F., Dardenne, M., Papiernik, M., Barois, A., Levasseur, P., and Le Brigand, H., 1972, Evidence for a serum factor produced by the human thymus,Lancet1: 1056–1058.

    Article  Google Scholar 

  • Bach, J. F., Dardenne, M., and Salomon, J. C., 1973, Studies on thymus products. IV. Absence of serum “thymic activity” in adult NZB and (NZB x NZW) F! mice,Clin. Exp. Immunol.14: 247–256.

    PubMed  CAS  Google Scholar 

  • Bach, J. F., Dardenne, M., and Clot, J., 1975, Evaluation of serum thymic hormone and of circulating T cells in rheumatoid arthritis and in systemic lupus erythematosus,Rheumatology6: 242–250.

    PubMed  CAS  Google Scholar 

  • Bach, M. A., and Charreire, J., 1979, Role of a circulating thymic factor in self recognition and self tolerance,Ann. N.Y. Acad. Sci.332: 55–63.

    Article  PubMed  CAS  Google Scholar 

  • Bach, M. A., Droz, D., Noel, L. H., Blanchard, D., Dardenne, M., and Peking, A., 1980, Effect of long- term treatment with circulating thymic factor on murine lupus,Arthritis Rheum. 23: 1351–1358.

    Article  PubMed  CAS  Google Scholar 

  • Basch, R. S., and Goldstein, G. 1974, Induction of T-cell differentiationin vitroby thymin, a purified polypeptide hormone of the thymus,Proc. Natl. Acad. Sci. U.S.A.71: 1474–1478.

    Article  PubMed  CAS  Google Scholar 

  • Bene, M. C., Faure, G., Bordigoni, P., Olive, S., and Duheille, J., 1982,In vitroinduction of monoclonal antibody-defined T-cell markers in lymphocytes from immunodeficient children by synthetic serum thymic factor (FTS),Clin. Exp. Immunol. 48:423–428.

    PubMed  CAS  Google Scholar 

  • Berrih, S., Savino, W., Azoulay, M., Dardenne, M., and Bach, J. F., 1984, Production of anti-thymulin (FTS) monoclonal antibodies by immunization against hyman thymic epithelial cells,J. Histochem. Cytochem.32: 432–438.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, S., Berrih, S., Dardenne, M., and Bach, J. F., 1983, Régulation in vitro de la secrétion de thymuline par les cellules épithéliales thymiques humaines.C. R. Acad. Sci. (Paris) (D)297: 63–65.

    CAS  Google Scholar 

  • Dardenne, M., and Bach, J. F., 1975, The sheep cell rosette assay for the evaluation of thymic hormones, in:Biological Activity of Thymic Hormones, (D. van Bekkumed.), Kooyker Science, Rotterdam, pp. 235–243.

    Google Scholar 

  • Dardenne, M., and Bach, J. F., 1977, Demonstration and characterization of a serum factor produced by activated T cells,Immunology33: 643.

    PubMed  CAS  Google Scholar 

  • Dardenne, M., Monier, J. C., Biozzi, G., and Bach, J. F., 1974, Studies on thymus products. V. Influence of genetic selection based on antibody production of thymic hormone production,Clin. Exp. Immunol.17: 339–344.

    PubMed  CAS  Google Scholar 

  • Dardenne, M., Pleau, J. M., Blouquit, J. Y., and Bach, J. F., 1980, Characterization of facteur thymique sérique (FTS) in the thymus II. Direct demonstration of the presence of FTS in thymosin fractionV. Clin. Exp. Immunol. 42: 477–482.

    CAS  Google Scholar 

  • Dardenne, M., Pleau, J. M., Savino, W., and Bach, J. F., 1982a, Monoclonal antibody against the serum thymic factor (FTS),Immunol. Lett.48: 61–69.

    Google Scholar 

  • Dardenne, M., Pleau, J. M., Nabarra, B., Lefrancier, P., Derrien, M., Choay, J., and Bach, J. F., 1982b, Contribution of zinc and other metals to the biological activity of the serum thymic factor,Proc. Natl. Acad. Sci. U.S.A.79: 5370–5373.

    Article  PubMed  CAS  Google Scholar 

  • Dardenne, M. Savino, W., Gastinel, L. N., Nabarra, B., and Bach, J. F., 1983, Thymic dysfunction in the mutant diabetic (db/db) mouse,J. Immunol. 130(3): 1195–1199.

    PubMed  CAS  Google Scholar 

  • Duclos, M., Zeidler, H., Liman, W., Pichler, W. J., Rieber, P., and Peter, H. H., 1982, Characterization of blood and synovial fluid lymphocytes from patients with rheumatoid arthritis and other joint diseases by monoclonal antibodies (OKT series) and acid alpha-naphtyl esterase staining,Rheumatol. Int. 2: 75–82.

    Article  PubMed  CAS  Google Scholar 

  • Fabris, N., 1980, Serum thymic factor determination in different human pathologies,Int. J. Immunopharmacol2: 157–160.

    Article  Google Scholar 

  • Faure, G., Bach, M. A., Bene, M. C., Kahn, M. F., Bach, J. F., and Gaucher, A., 1982, Etude des sous- populations lymphocytaires T au cours des rheumatismes inflammatoires chroniques,Rev. Rhum.49: 439–445.

    PubMed  CAS  Google Scholar 

  • Faure, G., Bene, M. C., Tamisier, J. N., Gaucher, A., and Duheille, J., 1984, Thymulin (FTS-Zn) inducedin vitromodulation of T cell subsets markers on lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients,Int. J. Immunopharmacol.6: 381–388.

    Article  PubMed  CAS  Google Scholar 

  • Garaci, E., Ronchetti, R., Del Gobbio, V., Tramutoti, G., Rinaldi-Garaci, C., and Imperato, C., 1978, Decreased serum thymic activity in asthmatic children,J. Allergy Clin. Immunol.62: 357–362.

    Article  PubMed  CAS  Google Scholar 

  • Gastinel, L. N., Dardenne, M., Pleau, J. M., and Bach, J. F., 1984, Studies on the zinc binding to the serum thymic factor,Biochim. Biophys. Acta.797: 147–155.

    PubMed  CAS  Google Scholar 

  • Goldstein, A. L., Guha, A., Zatz, M. M., Hardy, A., and White, A., 1972, Purification and biological activity of thymosin, a hormone of the thymus gland,Proc. Natl. Acad. Sci. U.S.A.69: 1800–1804.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, A. L., Low, T. L. K., McAdoo, M., McLure, J., Thurman, G. B., Rossio, J. J., Lai, C. Y., Chang, D., Wang, S. S., Harvey, C., Ramel, A. H., and Meienhoffer, J., 1977, Thymosin αl: Isolation and sequence analysis of an immunologically active thymic polypeptide,Proc. Natl. Acad. Sci. U.S.A.74: 725–729.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, G., 1974, Isolation of bovine thymin: A polypeptide hormone of the thymus,Nature, 247: 11–14.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, G., 1975, The isolation of thymopoietin (thymin),Ann. N.Y. Acad. Sci.249: 177–183.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, G., 1976, Radioimmunoassay for thymopoietin,J. Immunol.117: 690–692.

    PubMed  CAS  Google Scholar 

  • Goldstein, G., and Lau, C., 1980, Thymopoietin and immunoregulation, in:Polypeptide Hormones( R. F. Beers, Jr., and E. G. Bassett, eds.), Raven Press, New York, pp. 459–465.

    Google Scholar 

  • Goldstein, G., Scheid, M. P., Boyse, E. A., Schlesinger, D. H., and Van Vauwe, J., 1979, A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin,Science204: 1309–1310.

    Article  PubMed  CAS  Google Scholar 

  • Gualde, N., Rigaud, M., and Bach, J. F., 1982, Stimulation of prostaglandin synthesis by the serum factor (FTS),Cell Immunol. 70: 363–366.

    Google Scholar 

  • Hirokawa, K., McClure, J. E., and Goldstein, A. L., (1982) Age related changes in localization of thymosin in the human thymus,Thymus4: 19–29.

    PubMed  CAS  Google Scholar 

  • Israel-Biet, D., Noël, L. H., Bach, M. A., Dardenne, M., and Bach, J. F., 1983, Reversal of the autoimmune disease of (NZB x NZW) F1 mice by cyclosporin A and thymulin (FTS-Zn), Clin. Exp. Immunol. 54:359–365.

    PubMed  CAS  Google Scholar 

  • Iwata, T., Incefy, G. S., Good, R. A., Cunningham-Rundles, S., Dardenne, M., Kapoor, N., Kirkpatrick, D., and O’Reilly, R. J., 1983, Circulating thymic hormone levels in severe combined immunodeficiency,Clin. Exp. Immunol.53: 1–9.

    PubMed  CAS  Google Scholar 

  • Jambon, B., Montagne, P., Bene, M. C., Brayes, M. P., Faure, G., and Duheille, J., 1981, Immunohistologic localization of “facteur thymique sérique (FTS)” in human thymic epithelium,J. Immunol.127: 2055–2059.

    PubMed  CAS  Google Scholar 

  • Laghi-Pasini, F., Auteri, A., Pasqui, A. L., and Di Petro, T., 1980, Immunokinetics of a single dose of thymopoietin pentapeptide,Int. J. Immunopharmacol.2 /3: 154–155.

    Article  Google Scholar 

  • Low, T. L. K., Thurman, G. B., Chincarini, C., McClure, J. E., Marshall, G. D., Hu, S. K., and Goldstein, A. L., 1979, Current status of thymosin research: Evidence for the existence of a family of thymic factors that control T-cell maturation,Ann. N.Y. Acad. Sci.332: 33.

    Article  PubMed  CAS  Google Scholar 

  • McLure, J. E., Lameris, N., Wara, D. W., and Goldstein, A. L., 1981, Immunochemical studies on thymosin: Radioimmunoassay of thymosin al,J. Immunol.128: 368–375.

    Google Scholar 

  • Monier, J. C., Dardenne, M., Pleau, J. M., Schmitt, D., Deschaux, P., and Bach, J. F., 1980, Characterization of the facteur thymique serique (FTS) in the thymus. I. Fixation of anti-FTS antibodies on thymic reticulo-epithelial cells,Clin. Exp. Immunol.42: 470–476.

    PubMed  CAS  Google Scholar 

  • Moutsopoulos, H., Fye, K. H., Sawada, S., Becker, M. J., Goldstein, A., and Talal, N., 1976,In vitroeffect of thymosin on T-lymphocyte rosette formation in rheumatic diseases,Clin. Exp. Immunol. 26:563–573.

    PubMed  CAS  Google Scholar 

  • Osheroff, P. L., 1981, The effect of thymosin on glucocorticoid receptors in lymphoid cells,Cell. Immunol.60: 376.

    Article  PubMed  CAS  Google Scholar 

  • Pfreudschuh, M., Michel, H., Parino, G., Stock, C., Gause, A., and Hunstein, W., 1981, T-lymphocyte subpopulations in rheumatoid arthritis. II. Definition by monoclonal antibodies,Z. Rheumatol.40: 245–249.

    Google Scholar 

  • Pleau, J. M., Dardenne, M., Blouquit, Y., and Bach, J. F., 1977, Structural study of circulating thymic factor: A peptide isolated from pig serum. II. Amino acid sequence, J. Biol. Chem. 252:8045–8047.

    PubMed  CAS  Google Scholar 

  • Pleau, J. M., Pasques, D., Bach, J. F., Gros, E., and Dray, F., 1978, Dosage radioimmunologique du facteur thymique serique (FTS), in:Radioimmunoassay and Related Procedures in Medicine, Vol. II. International Atomic Energy Agency, Vienna, pp. 505–510.

    Google Scholar 

  • Pleau, J. M., Dardenne, M., Blanot, D., Bricas, I., and Bach, J. F., 1979, Antagonistic analogue of serum thymic factor (FTS) interacting with the FTS cellular receptor,Immunol. Lett.1: 179–182.

    Article  CAS  Google Scholar 

  • Pleau, J. M., Fuentes, V., Morgat, J. L., and Bach, J. F., 1980, Specific receptors for the serum thymic factor (FTS) in lymphoblastoid cultured cell lines.Proc. Natl. Acad. Sci. U.S.A.77: 2861–2865.

    Article  PubMed  CAS  Google Scholar 

  • Rinaldi-Garaci, C., Garaci, E., DelGobbo, V., Favalli, C., Jezzi, T., and Goldstein, A. L., 1983, Modulation of endogenous prostaglandins by thymosin αl in lymphocytes,Cell. Immunol.80: 57–65.

    Article  PubMed  CAS  Google Scholar 

  • Savino, W., Dardenne, M., Papiernik, M., and Bach, J. F., 1982, Thymic hormone containing cells, char-acterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies,J. Exp. Med.156: 628–634.

    Article  PubMed  CAS  Google Scholar 

  • Savino, W., Dardenne, M., and Bach, J. F., 1983a, Thymic hormone containing cells II. Evolution of cells containing the serum thymic factor (FTS or thymulin) in normal and autoimmune mice, as revealed by anti-FTS monoclonal antibodies. Relationship with la bearing cells,Clin. Exp. Immunol.52: 1–6.

    PubMed  CAS  Google Scholar 

  • Savino, W., Dardenne, M., and Bach, J. F., 1983b, Thymic hormone containing cells. III. Evidence for a feed-back regulation of the secretion of the serum thymic factor (FTS) by thymic epithelial cells,Clin. Exp. Immunol.52: 7–12.

    PubMed  CAS  Google Scholar 

  • Schlesinger, D. H., and Goldstein, G., 1975, The amino acid sequence of thymopoietin II,Cell5: 361–366.

    Article  PubMed  CAS  Google Scholar 

  • Schmitt, D., Monier, J. C., Dardenne, M., Pleau, J. M., and Bach, J. F., 1982, Location of FTS (facteur thymique serique) in the thymus of normal and autoimmune mice,Thymus4: 221–231.

    PubMed  CAS  Google Scholar 

  • Thrower, P. A., Doyle, D. V., Scott, J., and Huskisson, E. C., 1982, Thymopoietin in rheumatoid arthritis,Rheum. Rehabil.21: 72–77.

    Article  CAS  Google Scholar 

  • Thurman, G. B., Rossio, J. L., and Goldstein, A. L., 1977, Thymosin-induced enhancement of MIF production by peripheral blood lymphocytes of thymectomized guinea pigs, in:Regulatory Mechanisms in Lymphocyte Activation( D. O. Lucas, ed.), Academic Press, New York, pp. 629–631.

    Google Scholar 

  • Trainin, N., and Small, M., 1970, Studies on some physicochemical properties of a thymus humoral factor conferring immunocompetence on lymphoid cells,J. Exp. Med.132: 885–889.

    Article  PubMed  CAS  Google Scholar 

  • Twomey, J. J., Goldstein, G., Lewis, V. M., Bealmear, P. M., and Good, R. A., 1977, Biossay determinations of thymopoietin and thymic hormone levels in human plasma,Proc. Natl. Acad. Sci. U.S.A.74: 2541.

    Article  PubMed  CAS  Google Scholar 

  • Twomey, J. J., Goldstein, G., Lewis, V. M., Bealmear, P. M., and Good, R. A., 1977, Biossay determinations of thymopoietin and thymic hormone levels in human plasma,Proc. Natl. Acad. Sci. U.S.A74:2541.

    Article  PubMed  CAS  Google Scholar 

  • Veys, E. M., Hermans, P., Schindler, J., Kung, P. C., Goldstein, G., Symoens, J., and Van Wauwe, J., 1982a, Evaluation of T cell subsets with monoclonal antibodies in patients with rheumatoid arthritis,J. Rheumatol.9: 25–29.

    PubMed  CAS  Google Scholar 

  • Veys, E. M., Huskisson, E. C., Rosenthal, M., Vischer, T. L., Mielants, H., Thrower, P. A., Scott, J., Ott, H., Scheijgrond, H., and Symoens, J., 1982b, Clinical response to therapy with thymopoietin pentapeptide (TP-5) in rheumatoid arthritis,Ann. Rheum. Dis.41: 441–443.

    Article  PubMed  CAS  Google Scholar 

  • Wetzel, R., Heyweker, H. L., Goeddel, D. V., Jhurani, P., Shapiro, J., Crea, R., Low, T. L. K., McClure, J. E., Thurman, G. B., and Goldstein, A. L., 1980, Production of biologically active N alpha desacetyl thymosin αl inEscherichia colithrough expression of a chemically synthesized gene,J. Biol. Chem.19: 6096–6104.

    CAS  Google Scholar 

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Authors and Affiliations

  1. INSERM U 25, Hopital Necker, 75015, Paris, France

    J. F. Bach & M. Dardenne

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  1. J. F. Bach
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  2. M. Dardenne
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Editors and Affiliations

  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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© 1985 Plenum Publishing Corporation

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Bach, J.F., Dardenne, M. (1985). Thymic Hormones and Rheumatoid Arthritis. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_27

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  • DOI: https://doi.org/10.1007/978-1-4613-2493-5_27

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