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Psychoneuroimmunologic Contributions to the Study of Rheumatic Diseases

  • Chapter
Immunology of Rheumatic Diseases

Abstract

Psychosocial factors are related to the predisposition to and the precipitation and/or perpetuation of a variety of pathophysiological processes, including those involving immunologic defense mechanisms. That is not to say that psychosocial factors cause disease. I know of no organic disease that is directly “caused” by psychological or social conditions. There is abundant evidence, however, that psychosocial variables contribute to the development and progression of disease—not just some diseases, those referred to as “psychosomatic,” but, to a greater or lesser extent, virtually all diseases. One can adopt this position without denying the existence of “germs.” In the real world, however, individuals are rarely exposed to pathogens in a dose or via a route that unconditionally elicits clinical disease. Health, rather than illness, is the norm, and it is not uncommon to observe large individual differences among individuals exposed to common pathogenic stimuli.

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Authors and Affiliations

  1. Division of Behavioral and Psychosocial Medicine, Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Robert Ader

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  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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Ader, R. (1985). Psychoneuroimmunologic Contributions to the Study of Rheumatic Diseases. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_25

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  • DOI: https://doi.org/10.1007/978-1-4613-2493-5_25

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