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Immune Complexes, Vasoactive Mediators, and Fibrinoid Necrosis in Connective Tissue Diseases

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Immunology of Rheumatic Diseases

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Abstract

Although the inflammatory mechanisms operative in the various connective tissue diseases are all different, there are certain features common to many of them. These include tissue deposition of circulating immune complexes, a vasculopathy, and fibrinoid necrosis of the surrounding tissue. Other chapters in this text deal with immune complexes, activation of complement, and recruitment and activation of neutrophils, all of which are important aspects of immunologically mediated inflammation. This chapter focuses on the tissue deposition of immune complexes, the role of vasoactive factors in the inflammatory response, and the interrelationship of these events with coagulation and fibrinolysis to cause fibrinoid necrosis.

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References

  • Adu, J., and Williams, D., 1981, DNA-anti DNA circulating complexes in the nephritis of systemic lupus erythematosus, Clin. Exp. Immunol. 43:605–614.

    PubMed  CAS  Google Scholar 

  • Allen, R. A., and Pepper, D. C., 1981, Isolation and properties of human vascular plasminogen activator, Thromb. Haemostas. 45:43–50.

    CAS  Google Scholar 

  • Arnoux, B., Jouvin-Marche, E., Arnoux, A., and Benveniste, J., 1982, Release of PAF-acether from human blood monocytes, Agents Actions 12:713–716.

    PubMed  CAS  Google Scholar 

  • Bajaj, S. P., and Castellino, F. J., 1977, Activation of human plasminogen by equimolar levels of streptokinase, J. Biol. Chem. 252:492–498.

    PubMed  CAS  Google Scholar 

  • Barone, C., Bartolini, C., Jentiloni, N., Greico, A., and Flamini, G., 1981, Systemic lupus erythematosus with only IgE class antinuclear antibodies, Arthritis Rheum. 24:1441–1443.

    PubMed  CAS  Google Scholar 

  • Bar-Shavit, R., Kahn, A., Fenton, J. W., and Wilner, J. D., 1983, Chemotactic response of monocyte to thrombin, J. Cell Biol. 96:282–285.

    PubMed  CAS  Google Scholar 

  • Belch, J. J., Drury, J. K., Capell, H., Forbes, C. D., Newman, P., McKenzie, F., Lieberman, P., and Prentice, C. R. M., 1983, Intermittant epoprostenol (prostacyclin) infusion in patients with Raynaud’s syndrome, Lancet 1:313–315.

    PubMed  CAS  Google Scholar 

  • Beneveniste, J., Henson, P. M., and Cochrane, C. G., 1972, Leucocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and platelet activating factor, J. Exp. Med. 136:1356–1377.

    Google Scholar 

  • Betz, S. J., Lotner, G. Z., and Henson, P. M., 1980, Generation and release of platelet-activating factor (PAF) from enriched preparations of rabbit basophils; failure of human basophils to release PAF, J. Immunol. 125:2749–2755.

    PubMed  CAS  Google Scholar 

  • Binder, B. R., Spragg, J., and Austen, K. F., 1979, Purification and characterization of human vascular plasminogen activator derived from blood vessel pertusates, J. Biol. Chem. 254:1998–2003.

    PubMed  CAS  Google Scholar 

  • Blomback, B., Hessel, B., Hagg, D., and Therkildsen, L., 1978, A two-step fibrinogen-fibrin transition in blood coagulation, Nature 275:501–505.

    PubMed  CAS  Google Scholar 

  • Bock, P. E., and Shore, J. P., 1983, Protein-protein interactions in contact activation of blood coagulation. Characterization of a fluorescein-labeled human high molecular weight kininogen light chain as a probe, J. Biol. Chem. 258:15079–15083.

    PubMed  CAS  Google Scholar 

  • Bock, P. E., Srinivasan, K. R., and Shore, J. D., 1981, Activation of intrinsic blood coagulation by ellagic acid:Insoluble ellagic acid metal ion complexes are the activating species, Biochemistry 20:7258–7266.

    PubMed  CAS  Google Scholar 

  • Bockisch, V. A., and Muller-Eberhard, H. J., 1970, Anaphylatoxin inactivator of human plasma:Its isolation and characterization as a carboxypeptidase, J. Clin. Invest. 49:2427–2436.

    Google Scholar 

  • Bouma, B. N., and Griffin, J. N., 1977, Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII, J. Biol. Chem. 252:6432–6437.

    PubMed  CAS  Google Scholar 

  • Bouma, B. N., Keribiriou, D. M., Vlooswijk, R. A. A., and Griffin, J. H., 1980, Immunological studies of prekallikrein, kallikrein, and high molecular weight kininogen in normal and deficient plasmas and in normal plasma after cold-dependent activation, J. Lab. Clin. Med. 961:693–709.

    Google Scholar 

  • Bouma, B. N., Vlooswijk, R. A. A., and Griffin, J. H., 1983, Immunological studies of human factor XI and its complex with high molecular weight kininogen, Blood 62:1123–1131.

    PubMed  CAS  Google Scholar 

  • Brinckerhoff, C. E., McMillan, R. M., Fahey, J. V., and Harris, E. D., Jr., 1979, Collagenase production by synovial fibroblasts treated with phorbol myristate acetate, Arthritis Rheum. 22:1109–1116.

    PubMed  CAS  Google Scholar 

  • Broze, G. J., Jr., and Majerus, P. N., 1980, Purification and properties of human coagulation factor VII, J. Biol. Chem. 255:1242–1247.

    PubMed  CAS  Google Scholar 

  • Budzynski, A. Z., Marder, V. J., and Schainoff, J. R., 1974, Structure of plasmic degradation products of human fibrinogen. Fibrinopeptide and polypeptide chain analysis, J. Biol. Chem. 249:2294–2302.

    PubMed  CAS  Google Scholar 

  • Busch, C., and Owen, W. G., 1982, Identification in vitro of an endothelial cell surface cofactor for antithrombin III. Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium, J. Clin. Invest. 69:726–729.

    PubMed  CAS  Google Scholar 

  • Camussi, G., Aglietta, M., Coda, R., Bussolino, F., Piacibello, W., and Tetta, C., 1981, Release of platelet activating factor (PAF) and histamine II. The cellular origin of human PAF:Monocytes, polymorphonuclear neutrophils, and basophils, Immunology 42:191–199.

    PubMed  CAS  Google Scholar 

  • Camussi, G., Aglietta, M., Malavasi, F., Tetta, C., Piacibello, W., Sanavio, F., and Bussolino, F., 1983, The release of platelet-activating factor from human endothelial cells in culture, J. Immunol. 131:2397–2403.

    PubMed  CAS  Google Scholar 

  • Chan, J. Y. C., Movat, H. Z., and Burrowes, C. E., 1979, High molecular weight kininogen:Its inability to correct the clotting of kininogen deficient plasma after cleavage of bradykinin by plasma kallikrein, plasmin, or trypsin, Thromb. Res. 14:817–824.

    PubMed  CAS  Google Scholar 

  • Chused, T. M., and Tarplay, T., 1973, Antagonism of vasoactive amines in NZBAV glomerulonephritis. Beneficial effect of methylsergide, Proc. Soc. Exp. Biol. Med. 144:281 - 283.

    PubMed  CAS  Google Scholar 

  • Clark, P. O., Hanahan, D. J., and Pinckard, R. N., 1980, Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils, Biochim. Biophys. Acta 628:69–75.

    PubMed  CAS  Google Scholar 

  • Cochrane, C. G., and Revak, S. D., 1980, Dissemination of contact activation in plasma by plasma kallikrein, J. Exp. Med. 152:608–619.

    PubMed  CAS  Google Scholar 

  • Cochrane, C. G., Wuepper, K. D., Aiken, B. S., Revak, S. D., and Spiegelberg, H. L., 1972, The interaction of Hageman factor and immune complexes, J. Clin. Invest. 51:2736–2745.

    PubMed  CAS  Google Scholar 

  • Cochrane, C. G., Revak, S. D., and Wuepper, K. D., 1973, Activation of Hagemen factor in solid and fluid phase, J. Exp. Med. 138:1564–1578.

    PubMed  CAS  Google Scholar 

  • Cole, E. R., and Bachmann, F. W., 1977, Purification of a plasminogen activator from pig heart, J. Biol. Chem. 252:3729–3737.

    PubMed  CAS  Google Scholar 

  • Collen, D., 1976, Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma, Eur. J. Biochem. 69:209–216.

    PubMed  CAS  Google Scholar 

  • Colman, R. W., 1969, Activation of plasminogen by human plasma kallikrein, Biochem. Biophys. Res. Commun. 35:273–279.

    PubMed  CAS  Google Scholar 

  • Colman, R. W., Bagdasarian, A., Talamo, R. C., Scott, C. F., Seavey, M., Guimaraes, J. A., Pierce, J. V., and Kaplan, A. P., 1975, Williams trait:Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor-dependent pathways, J. Clin. Invest. 56:1650–1662.

    PubMed  CAS  Google Scholar 

  • Dahlen, S. E., Bjork, J., Hedgvist, P., Arfors, K. E., Hammarstrom, S., Lundgren, J. A., and Samuelsson, B., 1981, Leukotrienes promote plasma leakage and leukocyte adhesion in post capillary venules:In vivo effect with relevance to the acute inflammatory response, Proc. Natl. Acad. Sci. U.S.A. 78:3887–3891.

    PubMed  CAS  Google Scholar 

  • Damas, P. S., Hicks, M., and Rosenberg, R. D., 1973, Anticoagulant activity of heparin, Nature 246:355–357.

    Google Scholar 

  • Demopoulos, C. A., Pinckard, R. N., and Hanahan, D. J., 1979, Platelet activating factor. Evidence for 1- 0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators.), J. Biol. Chem. 25:9355–9358.

    Google Scholar 

  • Deuel, T. F., Senior, R. M., Change, D., Griffin, G. L., Heinrickson, R. L., and Kaiser, E. T., 1981, Platelet factor 4 is chemotactic for neutrophils and monocytes, Proc. Natl. Acad. Sci. U.S.A. 78:4584–4587.

    PubMed  CAS  Google Scholar 

  • Deuel, T. F., Senior, R. M., Huang, J. S., and Griffin, G. L., 1982, Chemotaxis of monocytes and neutrophils to platelet-derived growth factor, J. Clin. Invest. 69:1046–1049.

    PubMed  CAS  Google Scholar 

  • DiScipio, R. G., 1982, The activation of the alternative pathway C3 convertase by human plasma kallikrein, Immunology 45:587–595.

    PubMed  CAS  Google Scholar 

  • Dobson, N. J., Lambris, J. D., and Ross, G. D., 1981, Characteristics of isolated erythrocyte commplement receptor type one (CR1, C4b-C3b receptor) and CRi specific antibodies, J. Immunol. 126:693 - 698.

    PubMed  CAS  Google Scholar 

  • Donaldson, V. H., Glueck, H. I., and Fleming, T., 1972, Rheumatoid arthritis in a patient with Hageman trait, N. Engl. J. Med. 286:528–530.

    PubMed  CAS  Google Scholar 

  • Donaldson, V. H., Glueck, H. I., Miller, M. A., Movat, H. Z., and Habal, F., 1976, Kininogen deficiency in Fitzgerald trait:Role of high molecular weight kininogen in clotting and fibrinolysis, J. Lab. Clin. Med. 87:327–337.

    PubMed  CAS  Google Scholar 

  • Drazen, J. M., Austen, K. F., Lewis, R. A., Clark, D. A., Goto, G., Marfat, A., and Corey, E. J., 1980, Comparative airway and vascular reactivity of leukotrienes C-l and D in vivo and in vitro, Proc. Natl. Acad. Sci. 77:4354–4358.

    CAS  Google Scholar 

  • Dunn, J. T., and Kaplan, A. P., 1982, Formation and structure of human Hageman factor fragments, J. Clin. Invest. 70:627–631.

    PubMed  CAS  Google Scholar 

  • Dunn, J. T., Silverberg, M., and Kaplan, A. P., 1982, The cleavage and formation of activated Hageman factor by autodigestion and by kallikrein, J. Biol. Chem. 257:1779–1784.

    PubMed  CAS  Google Scholar 

  • Edwards, R. L., and Rickles, F. R., 1980, The role of human T cells (and T cell products) for monocyte tissue factor generation, J. Immunol. 125:606–609.

    PubMed  CAS  Google Scholar 

  • Erdos, E. C., and Sloane, E. M., 1962, An enzyme in human plasma that inactivated bradykinin and kallidins, Biochem. Pharmacol. 11:585–592.

    PubMed  CAS  Google Scholar 

  • Esmon, C. T., and Jackson, C. M., 1974, The conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor V, J. Biol. Chem. 249:7791–7797.

    PubMed  CAS  Google Scholar 

  • Esmon, C. T., and Owen, W., 1981, Identification of an endothelial cell cofactor for Thrombin-catalyzed activation of protein C, Proc. Natl. Acad. Sci. U.S.A. 78:2249–2252.

    PubMed  CAS  Google Scholar 

  • Esmon, C. T., Suttie, J. W., and Jackson, C. M., 1975, The functional significance of vitamin K action. Difference in phospholipid binding between normal and abnormal prothrombin, J. Biol. Chem. 250:4095–4099.

    PubMed  CAS  Google Scholar 

  • Fields, T. R., Gerardi, E. N., Ghebrehiwet, B., Bennett, R. S., Lawley, T. J., Hall, R. P., Plotz, P., Karsh, J. R., Frank, M. M., and Hamburger, M. I., 1983a, Reticuloendothelial system Fc receptor function in rheumatoid arthritis, J. Rheumatol. 10:550–557.

    PubMed  CAS  Google Scholar 

  • Fields, T. R., Ghebrehiwet, B., and Kaplan, A. P., 1983b, Kinin formation in hereditary angioedema plasma:Evidence against kinin derivation from C2 and in support of “spontaneous” formation of bradykinin, J. Allergy Clin. Immunol. 72:54–60.

    PubMed  CAS  Google Scholar 

  • Flower, R. J., Harvey, E. A., and Kingston, W. P., 1976, Inflammatory effects of prostaglandin D2 in rat and human skin, Br. J. Pharmacol. 56:229–233.

    PubMed  CAS  Google Scholar 

  • Forbes, C. O., Pensky, J., and Ratnoff, O. D., 1970, Inhibition of activated Hageman factor and activated plasma thromboplastin antecedent by purified C inactivator, J. Lab. Clin. Med. 76:809–815.

    PubMed  CAS  Google Scholar 

  • Frank, M. M., Schreiber, A. D., Atkinson, J. P., and Jaffe, C. J., 1977, Pathophysiology of immune hemolytic anemia, Ann. Intern. Med. 87:210–222.

    Google Scholar 

  • Frank, M. M., Hamburger, M. I., Lawley, T. J., Kimberly, R. P., and Plotz, P. H., 1979, Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus, N. Engl. J. Med. 300:518–523.

    PubMed  CAS  Google Scholar 

  • Fries, L. F., Mullins, W. W., Cho, K. R., Plotz, P. H., and Frank, M. M., 1984, Monocyte receptors for the Fc portion of IgG are increased in systemic lupus erythematosus, J. Immunol. 132:685–700.

    Google Scholar 

  • Fujikawa, K., and McMuIlen, B. A., 1983, Amino acid sequence of human ß factor Xlla, J. Biol. Chem. 258:10924–10933.

    PubMed  CAS  Google Scholar 

  • Fujikawa, K., Heimark, R. L., Kurachi, K., and Davie, E. W., 1980, Activation of bovine factor XII (Hageman factor) by plasma kallikrein, Biochemistry 19:1322–1330.

    PubMed  CAS  Google Scholar 

  • Fujimoto, T., O’Hara, S., and Hawiger, J., 1982, Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/Von Willebrand factor on human platelets, J. Clin. Invest. 69:1212–1222.

    PubMed  CAS  Google Scholar 

  • Gallin, J. I., and Kaplan, A. P., 1974, Mononuclear cell chemotactic activity of kallikrein and plasminogen activator and its inhibition by Cl inhibitor and a2 macroglobulin, J. Immunol. 113:1928–1934.

    PubMed  CAS  Google Scholar 

  • Gartner, T. K., Williams, D. C., Minion, F. C., and Phillips, D. R., 1978, Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin, Science 200:1281–1283.

    PubMed  CAS  Google Scholar 

  • Ghebrehiwet, B., Silverberg, M., and Kaplan, A. P., 1981, Activation of the classical pathway of complement by Hageman factor fragment, J. Exp. Med. 153:665–676.

    PubMed  CAS  Google Scholar 

  • Ghebrehiwet, B., Randazzo, B. P., Dunn, J. T., Silverberg, M., and Kaplan, A. P., 1983, Mechanisms of activation of the classical pathway of complement by Hagemen factor fragment, J. Clin. Invest. 71:1450–1456.

    PubMed  CAS  Google Scholar 

  • Gigli, I., Mason, J. W., Colman, R. W., and Austen, K. F., 1970, Interaction of plasma kallikrein with the Cl inhibitor, J. Immunol. 104:574–581.

    PubMed  CAS  Google Scholar 

  • Ginsberg, M. H., Jaques, B., Cochrane, C. G., and Griffin, J. H., 1980, Urate crystal dependent cleavage of Hageman factor in plasma and synovial fluid, J. Lab. Clin. Med. 45:497–506.

    Google Scholar 

  • Goetzl, E. J., and Pickett, W. C., 1981, Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B, J. Exp. Med. 153:482–487.

    PubMed  CAS  Google Scholar 

  • Goetzl, E. J., Derian, C. K., Tauber, A. I., and Valone, F. H., 1980, Novel effects of l-O-hexadecyl-2-acyl- M-glycero-3-phosphorylcholine mediators in human neutrophil functions:Delineation of the specific roles of the acyl substituents, Biochem. Biophys. Res. Commun. 94:881–888.

    PubMed  CAS  Google Scholar 

  • Goldsmith, G., Saito, H., and Ratnoff, O., 1978, The activation of plasminogen by Hageman factor (factor XII) and Hageman factor fragments, J. Clin. Invest. 62:54–60.

    PubMed  CAS  Google Scholar 

  • Granelli-Piperno, P., Vassalli, J. D., and Reich, E., 1977, Secretion of plasminogen activation by human polymorphonuclear leukocytes:Modulation by glucocorticoids and other effectors, J. Exp. Med. 146:1693–1706.

    PubMed  CAS  Google Scholar 

  • Greenquist, A. C., and Colman, R. W., 1975, Bovine factor V: A calcium-containing metalloprotein, Blood 46:769–782.

    PubMed  CAS  Google Scholar 

  • Griffin, J. H., 1978, Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII), Proc. Natl. Acad. Sci. U.S.A. 75:1998–2002.

    PubMed  CAS  Google Scholar 

  • Griffin, J. H., and Beretta, G., 1979, Molecular mechanisms of surface-dependent activation of Hageman factor (factor XII), Adv. Exp. Med. Biol. 120:39–51.

    Google Scholar 

  • Griffin, J. H., and Cochrane, C. G., 1976, Mechanism for the involvement of HMW-kininogen in surface- dependent reactions of Hageman factor, Proc. Natl. Acad. Sci. U.S.A. 73:2559–2563.

    Google Scholar 

  • Griffith, M. J., 1982, The heparin-enhanced antithrombin III/thrombin reaction is saturable with respect to both thrombin and antithrombin III, J. Biol. Chem. 257:13899–13902.

    PubMed  CAS  Google Scholar 

  • Haakenstad, A. O., and Mannick, M., 1974, Saturation of the reticuloendothelial system with soluble immune complexes, J. Immunol. 112:1939–1948.

    PubMed  CAS  Google Scholar 

  • Habal, F. M., Movat, H. Z., and Burrowes, C. E., 1974, Isolation of two functionally different kininnogens from human plasma; separation from proteinase inhibitors and interaction with plasma kallikrein, Biochem. Pharmacol. 23:2291–2302.

    PubMed  CAS  Google Scholar 

  • Hall, R. P., Lawley, T. J., Heck, J. A., and Katz, S. I., 1980, IgA containing immune complexes in dermatitis herpetiformis, Henoch-Schonlein’s purpura systemic lupus erythematosus, and other diseases, Clin. Exp. Immunol. 40:31–37.

    Google Scholar 

  • Halonen, M., Palmer, J. D., Lohman, I. C., McManus, L. M., and Pinckard, K. N., 1980, Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorycholine (AGEPC), a mediator of IgE anaphylaxis in the rabbit, Am. Rev. Respir. Dis. 122:915–924.

    PubMed  CAS  Google Scholar 

  • Hamburger, M. I., Gorevic, P. D., Lawley, T. J., Franklin, E. C., and Frank, M. M., 1979a, Mixed cryoglobulinemia: Association of glomerulonephritis with defective reticuloendothelial system Fc receptor function, Trans. Assoc. Am. Physicians 91:104–112.

    Google Scholar 

  • Hamburger, M. I., Moutsopoulos, H. M., Lawley, T. J., and Frank, M. M., 1979b, Sjogren’s syndrome: A defect in reticuloendothelial system Fc-receptor specific clearance, Ann. Intern. Med. 91:534–538.

    PubMed  CAS  Google Scholar 

  • Hamburger, M. I., Gerardi, E. N., Fields, T. R., and Bennett, R. S., 1981, Reticuloendothelial system Fc receptor function and plasmapheresis in systemic lupus erythematosus. A preliminary report, Artif. Organs 5:264–268.

    PubMed  CAS  Google Scholar 

  • Hamburger, M. I., Lawley, T. J., Kimberly, R. P., Plotz, P. H., and Frank, M. M., 1982, A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus, Arthritis Rheum. 25:48–54.

    PubMed  CAS  Google Scholar 

  • Hanahan, D. J., Demopoulos, C. A., Liehr, J., and Pinckard, R. N., 1980, Identification of platelet-activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine, J. Biol. Chem. 225:5514–5516.

    Google Scholar 

  • Harpel, P. C., 1970, Human plasma alpha 2-macroglobulin. An inhibitor of plasma kallikrein, J. Exp. Med. 132:329–352.

    PubMed  CAS  Google Scholar 

  • Harpel, P. C., 1972, Studies on the interaction between collagen and a plasma kallikrein-like activity, J. Clin. Invest. 51:1813–1822.

    PubMed  CAS  Google Scholar 

  • Harpel, P. C., and Rosenberg, R. O., 1976, α2 Macroglobulin and anti-thrombin-heparin cofactor: Modulators of hemostatic and inflammatory reactions, Prog. Hemostas. Thromb. 3:145–191.

    CAS  Google Scholar 

  • Heck, L. W., and Kaplan, A. P., 1974, Substrates of Hageman factor I. Isolation and characterization of human factor XI (PTA) and inhibition of the activated enzyme by α1 antitrypsin, J. Exp. Med. 140:1615–1630.

    PubMed  CAS  Google Scholar 

  • Heimark, R. L., Kurachi, K., Fujikawa, K., and Davie, E. N., 1980, Surface activation of blood coagulation, fibrinolysis, and kinin formation, Nature 286:456–460.

    PubMed  CAS  Google Scholar 

  • Hibbard, L. S., and Mann, K. G., 1980, The calcium binding properties of bovine factor V, J. Biol. Chem. 255:638–645.

    PubMed  CAS  Google Scholar 

  • Highsmith, R. F., and Rosenberg, R. D., 1974, The inhibition of human plasma by human anti-thrombin-heparin cofactor, J. Biol. Chem. 249:4335–4338.

    PubMed  CAS  Google Scholar 

  • Holmsen, H., 1972, The platelet:Its membrane, physiology, and biochemistry, Clin. Haematol. 1:235–266.

    Google Scholar 

  • Hoyer, L. W., 1981, The factor VIII complex:Structure and function, Blood 58:1–11.

    PubMed  CAS  Google Scholar 

  • Hultin, M. B., 1982, Role of human factor VIII in factor X activation, J. Clin. Invest. 69:950–958.

    PubMed  CAS  Google Scholar 

  • Humphrey, D. M., McManus, L. M., Satouchi, K., Hanahan, D. J., and Pinckard, R. N., 1982, Vasoactive properties of acetyl glyceryl ether phosphorylcholine (AGEPC) and AGEPC analogues, Lab. Invest. 46:422–427.

    PubMed  CAS  Google Scholar 

  • Iida, K., Marnaghi, R., and Nussenzweig, V., 1982, Complement receptor (CRi) deficiency in erythrocytes from patients with systemic lupus erythematosus, J. Exp. Med. 155:1427–1438.

    PubMed  CAS  Google Scholar 

  • Issekutz, A. C., and Movat, H. Z., 1982, The effect of vasodilator prostaglandins on polymorphonuclear leucocyte infiltration and vascular injury, Am. J. Pathol. 107:300–309.

    PubMed  CAS  Google Scholar 

  • Izui, S., Lambert, P. H., and Miescher, P. A., 1976, In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA, J. Exp. Med. 144:428–443.

    PubMed  CAS  Google Scholar 

  • Jaffe, C. J., Vierling, J. M., Jones, E. A., Lawley, T. J., and Frank, M. M., 1978, Receptor specific clearance by the reticuloendothelial system in chronic liver diseases:Demonstration of defective C3b-specific clearance in primary biliary cirrhosis, J. Clin. Invest. 62:1069–1077.

    PubMed  CAS  Google Scholar 

  • Jorg, A., Henderson, W. R., Murphy, R. C., and Klebanoff, J. J., 1982, Leukotriene generation by eosinophils, J. Exp. Med. 155:390–402.

    PubMed  CAS  Google Scholar 

  • Kane, W. H., Lindhout, M. J., Jackson, C. M., and Majerus, P. W., 1980, Factor Va dependent binding of factor Xa to platelets, J. Biol. Chem. 255:1170–1174.

    PubMed  CAS  Google Scholar 

  • Kaplan, A. P., 1983, Hageman factor dependent pathways:Mechanism of initiation and bradykinin formation, Fed. Proc. 42:3123–3127.

    PubMed  CAS  Google Scholar 

  • Kaplan, A. P., and Austen, K. F. 1970, A prealbumin activator of prehallikrein, J. Immunol. 105:802–811.

    PubMed  CAS  Google Scholar 

  • Kaplan, A. P., and Austen, K. F., 1971, A prealbumin activator of prekallikrein II. Derivation of activators of prekallikrein from active Hageman factor by digestion with plasmin, J. Exp. Med. 133:696–712.

    PubMed  CAS  Google Scholar 

  • Kaplan, A. P., Kay, A. B., and Austen, K. F., 1972, A prealbumin activator of prekallikrein III. Appearance of chemotactic activity in human neutrophils by the conversion of human prekallikrein to kallikrein, J. Exp. Med. 135:81–97.

    PubMed  CAS  Google Scholar 

  • Kato, H., Han, Y. N., Iwanaga, S., Suzuki, T., and Komiya, M., 1976, Bovine plasma HMW and LMW kininogens. Structural differences between heavy and light chains derived from the kinin-free proteins, J. Biochem. 80:1299–1311.

    PubMed  CAS  Google Scholar 

  • Kay, A. B., Pepper, D. S., and Ewart, M. R., 1973, Generation of chemotactic activity for leukocytes by the action of thrombin on human fibrinogen, Nature (New Biol.) 243:56–57.

    CAS  Google Scholar 

  • Kellermeyer, R. W., and Breckenridge, R. T., 1965, The inflammatory process in acute gouty arthritis I. Activation of Hageman factor by sodium urate crystals, J. Lab. Clin. Med. 65:307–315.

    PubMed  CAS  Google Scholar 

  • Keribiriou, D. M., and Griffin, J. H., 1979, Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule during contact activation of plasma, J. Biol. Chem. 254:12020–12027.

    Google Scholar 

  • Khoory, M. S., Nesheim, M. E., Bowie, E. J. W., and Mann, K. G., 1980, Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder, J. Clin. Invest. 653:666–674.

    Google Scholar 

  • Kisiel, W., 1979, Human plasma protein C. Isolation, characterization, and mechanism of activation by a thrombin, J. Clin. Invest. 64:761–769.

    PubMed  CAS  Google Scholar 

  • Kitamura, N., Takagaki, Y., Furoto, S., Tanaka, T., Nawa, H., and Nakanishi, S., 1983, A single gene for bovine high molecular weight and low molecular weight kininogens, Nature 305:545–549.

    PubMed  CAS  Google Scholar 

  • Klickstein, L. B., Shapleigh, C., and Goetzl, E. J., 1980, Lipoxygenation of arachidonic acid as a source of PMN leucocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondylarthritis, J. Clin. Invest. 66:1166–1170.

    PubMed  CAS  Google Scholar 

  • Knauer, K. A., Lichtenstein, L. M., Adkinson, N. F., and Fish, J. E., 1981, Platelet activation during antigen- induced airway reactions in human asthmatics, N. Engl. J. Med. 304:1404–1406.

    PubMed  CAS  Google Scholar 

  • Knicker, W. J., 1972, Modulation of the inflammatory response in vivo:Prevention or amelioration of immune complex disease, in:Inflammation—Mechanisms and Control ( P. Ward and I. Lepow, eds.), Academic Press, New York, p. 335–367.

    Google Scholar 

  • Knicker, W. T., and Cochrane, G. G., 1968, Localization of circulating antigen-antibody complexes in serum sickness:The role of vasoactive amines and hydrodynamic forces, J. Exp. Med. 127:119–130.

    Google Scholar 

  • Kruithof, E. K. O., Ransijn, A., Tren-Thang, C., and Bachmann, F., 1983, Characteristics of a fast-acting inhibitor of plasminogen activator in human plasma, Thrombos. Haemostat. 50:193.

    Google Scholar 

  • Kurachi, K., Fujikawa, K., and Davie, E. W., 1980, Mechanism of activation of bovine factor XI by factor XII and factor Xlla, Biochemistry 19:1330–1338.

    PubMed  CAS  Google Scholar 

  • Larson, A. E., and Suttie, J. W., 1978, Vitamin K-dependent carboxylase:Evidence for a hydroperoxide intermediate in the reaction, Proc. Natl. Acad. Sci. U.S.A. 75:5413–5416.

    PubMed  CAS  Google Scholar 

  • Lawley, T. J., Hall, R. P., Fauci, A. S., Katz, S. I., Hamburger, M. I., and Frank, M. M., 1981, Defective Fc receptor functions associated with the HLA-B8/DRW3 haplotype, N. Engl. J. Med. 304:185–192.

    PubMed  CAS  Google Scholar 

  • Leung, L. L. K., and Nachman, R. L., 1984, Complex formation of platelet thrombospondin with fibrinogen, J. Clin. Invest. 73:5–12.

    PubMed  CAS  Google Scholar 

  • Lewin, M. F., Kaplan, A. P., and Harpel, P. C., 1983, Studies of Cl Inactivator-plasma kallikrein complexes in purified systems and in plasma. Quantification by an enzyme-linked differential antibody immunosorbent assay, J. Biol. Chem. 238:6415–6421.

    Google Scholar 

  • Lewis, R. A., Austen, K. F., Drazen, J. M., Clark, D. A., Marfat, A., and Corey, E. J., 1980, Slow reacting substances of anaphylaxis:Identification of leukotrienes C-l and D from human and rat sources, Proc. Natl. Acad. Sci. U.S.A. 77:3710–3714.

    CAS  Google Scholar 

  • Lewis, R. A., Soter, N. A., Diamond, P. T., Austen, K. F., Oates, J. A., and Roberts, L. J., II, 1982, Prostaglandin D2 generation after activation of rat and human mast cells with anti IgE, J. Immunol. 129:1627–1631.

    PubMed  CAS  Google Scholar 

  • Lijnen, H. R., Hoylaerts, M., and Collen, D., 1980, Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen, J. Biol. Chem. 255:10214–10222.

    PubMed  CAS  Google Scholar 

  • Lockwood, C. M., Worlledge, S., Nicholson, A., Cotton, C., and Peters, D. K., 1979, Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange, N. Engl. J. Med. 300:524–530.

    PubMed  CAS  Google Scholar 

  • Londsdale-Eccles, J. D., Neurath, H., and Walsh, K. A., 1978, Probes of the mechanism of zymogen catalysis, Biochemistry 17:2805–2809.

    Google Scholar 

  • Lorand, L., 1972, Fibrinoligase:The fibrin-stabilizing factor system of blood plasma, Ann. N.Y. Acad. Sci. 202:6–30.

    PubMed  CAS  Google Scholar 

  • Lotner, G. Z., Lynch, J. M., Betz, S. J., and Henson, P. M., 1980, Human neutrophil-derived platelet activating factor, J. Immunol. 124:676–684.

    PubMed  CAS  Google Scholar 

  • MacGlashan, D. W., Schleimer, R. P., Peters, S. P., Schulman, E. S., Adams, G. K., Sobotka, A. K., Newball, H. H., and Lichtenstein, L. M., 1983, Comparative studies of human basophils and mast cells, Fed. Proc. 42:2504–2509.

    PubMed  CAS  Google Scholar 

  • Mandle, R. J., and Kaplan, A. P., 1977, Hageman factor substrates:Human prekallikrein. Mechanism of activation by Hageman factor and participation in Hageman factor dependent fibrinolysis, J. Biol. Chem. 252:6097–6104.

    PubMed  CAS  Google Scholar 

  • Mandle, R. J., Jr., and Kaplan, A. P., 1979, Hageman-factor dependent fibrinolysis:Generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen, Blood 54:850–862.

    PubMed  CAS  Google Scholar 

  • Mandle, R. J., Colman, R. W., and Kaplan, A. P., 1976, Identification of prekallikrein and HMW-kininogen as a circulating complex in human plasma, Proc. Natl. Sci. U.S.A. 73:4179–4183.

    CAS  Google Scholar 

  • Manniok, M., Haakenstad, A. D., and Arend, W. P., 1974, The fate and detection of circulating immune complexes, Prog. Immunol. 5:91–101.

    Google Scholar 

  • Marcus, A. J., 1969, Platelet function, N. Engl. J. Med. 280:1213–1220, 1278–1284, 1330–1335.

    PubMed  CAS  Google Scholar 

  • Marder, V. J., Budzynski, A. Z., and James, H. L., 1982, High molecular weight derivative of human fibrinogen produced by plasma III. Their NH2-terminal amino acids and comparison with NH2-terminal disulfide knot, J. Biol. Chem. 247:4775–4781.

    Google Scholar 

  • Margalit, R., and Schiffman, S., 1980, Factor XI adsorption to surfaces:Interaction of high molecular weight kininiogen (HMWK) and a plasma adsorption inhibitor, Blood 56:168–172.

    PubMed  CAS  Google Scholar 

  • Marler, R. A., Kleiss, A. J., and Griffin, J. H., 1982a, An alternative extrinsic pathway of human blood coagulation, Blood 60:1353–1358.

    Google Scholar 

  • Marler, R. A., Kleiss, A. J., and Griffin, J. H., 1982b, Mechanism of action of human activated protein C, a thrombin dependent anticoagulant enzyme, Blood 59:1067–1072.

    Google Scholar 

  • Marr, J., Barboriak, J. J., and Johnson, S. A., 1965, Relationship of appearance of adenosine diphosphate, fibrin formation, and platelet aggregation in the haemostatic plus in vivo. Nature 205:259–262.

    CAS  Google Scholar 

  • Martin, M. F., Dowd, P., Ring, E., Cooke, E., Dieppe, P., and Kirby, J., 1981, Prostaglandin E-l infusions for vascular insufficiency in progressive systemic sclerosis, Ann. Rheum. Dis. 40:350–354.

    PubMed  CAS  Google Scholar 

  • McMillan, C. R., Saito, H., Ratnoff, O. D., and Walton, A. G., 1974, The secondary structure of human Hageman factor (factor XII) and its alteration by activating agents, J. Clin. Invest. 54:1312–1322.

    Google Scholar 

  • Meier, H. L., Pierce, J. V., Colman, R. W., and Kaplan, A. P., 1977a, Activation and function of human Hageman factor; the role of HMW-kininogen and prekallikrein, J. Clin. Invest. 60:18–31.

    PubMed  CAS  Google Scholar 

  • Meier, H. L., Thompson, R. E., and Kaplan, A. P., 1977b, Activation of Hageman factor by factor Xla-HMW- kininogen, Thromb. Haemostas. 38:14.

    Google Scholar 

  • Meuth, J. L., Morgan, E. L., DiScipio, R. G., and Hugli, T. E., 1983, Suppression of T lymphocyte functions by human C3 fragments I. Inhibition of human T cell proliferative responses by a kallikrein cleavage fragment of human i C3b, J. Immunol. 130:2605 - 2611.

    PubMed  CAS  Google Scholar 

  • Mikaelsson, M. E., Forsman, N., and Oswaldsson, D. M., 1983, Human factor VIII: A calcium-linked protein complex, Blood 62:1006–1015.

    PubMed  CAS  Google Scholar 

  • Miles, L. A., Burnier, J. P., Verlander, M. S., Goodman, M., Kleiss, A. J., and Griffin, J. H., 1981, Inactivation of purified human a2 antiplasmin and purified human C Inhibitor by synthetic fibrinolytic agents, Blood 57:1015–1024.

    PubMed  CAS  Google Scholar 

  • Miles, L. P., Rothschild, Z., and Griffin, J. H., 1983, Dextran sulfate-dependent fibrinolysis in whole human plasma, J. Lab. Clin. Med. 101:214–225.

    PubMed  CAS  Google Scholar 

  • Miletich, J. P., Kane, W. H., Hofmann, S. L., Stanford, N., and Majerus, P. W., 1979, Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder, Blood 54:1015–1022.

    PubMed  CAS  Google Scholar 

  • Miller, G., Silverberg, M., and Kaplan, A. P., 1980, Autoactivatability of human Hageman factor (factor XII), Biochem. Biophys. Res. Commun. 92:803–810.

    PubMed  CAS  Google Scholar 

  • Miyaka, Y., Yamada, A., Kosaka, K., Tsuda, F., Kosugi, E., and Mayami, M., 1981, Defective immune adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus, Lancet 2:493–497.

    Google Scholar 

  • Mori, K., and Nagasawa, S., 1981, Studies on human high molecular weight (HMW) kininogen II. Structural change of HMW-kininogen by the action of human plasma kallikrein, J. Biochem. 89:1465–1473.

    PubMed  CAS  Google Scholar 

  • Moroi, M., and Aoki, N., 1976, Isolation and characterization of a2 plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis, J. Biol. Chem. 251:5956–5965.

    PubMed  CAS  Google Scholar 

  • Morrison, D. C., and Cochrane, C. G., 1974, Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins), J. Exp. Med. 140:797–811.

    PubMed  CAS  Google Scholar 

  • Moser, D. F., 1976, Action of fibrin-stabilizing factor on cold-insoluble globulin and a2-macroglobulin in clotting plasma, J. Biol. Chem. 251:1639–1645.

    Google Scholar 

  • Mosesson, M. W., and Umfleet, R., 1980, The cold insoluble globulin of human plasma I. Purification, primary characterization, and relationship to fibrinogen and other cold insoluble fraction components, J. Biol. Chem. 245:5726–5736.

    Google Scholar 

  • Mosher, D. F., and Fucht, L. J., 1981, Fibronectin:Review of its structure and possible functions, J. Invest. Dermatol. 77:175–180.

    PubMed  CAS  Google Scholar 

  • Mullertz, S., and Clemmensen, I., 1976, The primary inhibitor of plasmin in human plasma, Biochem. J., 159:545–553.

    PubMed  CAS  Google Scholar 

  • Munns, T. W., Johnston, M. F. M., Liszewski, M. K., and Olson, R. E., 1976, Vitamin K-dependent synthesis and modification of precursor prothrombin in cultured H-35 hepatoma cells, Proc. Natl. Acad. Sci. U.S.A. 76:2803–2807.

    Google Scholar 

  • Murphy, R. C., Hammarstrom, S., and Samuelsson, B., 1979, Leucotriene C: A slow reacting substance from murine mastocytoma cells, Proc. Natl. Acad. Sci. U.S.A. 76:4275–4279.

    PubMed  CAS  Google Scholar 

  • Nachman, R. L., Weksler, B., and Ferris, B., 1970, Increased vascular permeability produced by human platelet granule cationic extract, J. Clin. Invest. 49:274–281.

    PubMed  CAS  Google Scholar 

  • Nagase, H., Jackson, R. C., Brickerhoff, C. E., Vater, C. A., and Harris, E. D., Jr., 1981, A precursor form of latent collagenase produced in a cell-free system with RNA from rabbit synovial cells, J. Biol. Chem. 256:11951–11954.

    PubMed  CAS  Google Scholar 

  • Nesheim, M. E., 1983, A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and heparin, J. Biol. Chem. 258:14708–14717.

    PubMed  CAS  Google Scholar 

  • Niemetz, J., 1972, Coagulant activity of leukocytes. Tissue factor activity, J. Clin. Invest. 51:307–313.

    PubMed  CAS  Google Scholar 

  • Nishimura, K., Alhene-Gelas, F., White, A., and Erdos, E.G., 1980, Activation of membrane-bound kallikrein and renin in the kidney, Proc. Natl. Acad. Sci. U.S.A. 77:4975–978.

    PubMed  CAS  Google Scholar 

  • Norris, D. A., Clark, R. A. F., Swigart, L. M., Huff, J. C., Weston, W. L., and Howell, S. E., 1982, Fibronectin fragment(s) are chemotactic for human peripheral blood monocytes, J. Immunol. 129:1612–1618.

    PubMed  CAS  Google Scholar 

  • Olson, S. T., and Shore, J. D., 1982, Demonstration of a two step reaction mechanism for inhibition of a thrombin by antithrombin in and identification of the step affected by heparin, J. Biol. Chem. 257:14891–14895.

    PubMed  CAS  Google Scholar 

  • Orning, L., Widegran, D., Hammarstrom, S., and Samuelsson, B., 1980, Leucotriene D, a slow reacting substance from rat basophilic leukemia cells, Proc. Natl. Acad. Sci. U.S.A. 77:2014–2017.

    PubMed  CAS  Google Scholar 

  • Orstavik, J. B., Brandtzaeg, P., Nustad, K., and Pierce, J. V., 1980, Immunohistochemical localization of kallikrein in human pancreas and salivary glands, J. Histochem. Cytochem. 28:557–562.

    PubMed  CAS  Google Scholar 

  • Osterud, B., and Rapaport, I., 1977, Activation of factor IX by the reaction product of tissue factor and factor VII: Additional pathway for initiating blood coagulation, Proc. Natl. Acad. Sci. U.S.A. 74:5260–5264.

    PubMed  CAS  Google Scholar 

  • Pareis, T. M., Kimberly, R. P., Inman, R. D., McDougal, S., Gibotsky, A., and Christian, C. L., 1982, Defective Fc receptor-mediated function of the mononuclear phagocyte system in lupus nephritis, Ann. Intern. Med. 98:526–532.

    Google Scholar 

  • Parker, C. W., Jakschik, B. A., Huber, M. G., and Falkenhein, S. F., 1979, Characterization of slow recting substance as a family of thiolipids derived from arachidonic acid, Biochem. Biophys. Res. Commun. 89:1186–1192.

    PubMed  CAS  Google Scholar 

  • Peters, S. P., MacGlashan, D. W., Jr., Schulman, E. S., Schleimer, R. P., Hayes, E. C., Rokach, J., AdkinsOn, N. F., Jr., and Lichtenstein, L. M., 1984, Arachidonic acid metabolism in purified human lung mast cells, J. Immunol. 132:1972 - 1979.

    PubMed  CAS  Google Scholar 

  • Pinckard, R. N., Knicker, W. T., Lee, L., Hanahan, D. J., and McManus, L. M., 1980, Vasoactive effects of l-0-alkyl-2-acetyl-M-glyceryl-3-phosphorylcholine (AGEPC) in human skin, J. Allergy Clin. Immunol. 65:196.

    Google Scholar 

  • Pisano, J. J., Bronzert, T. J., and Peyton, M. P., 1972, Cy-Glutamyl) lysine cross-links:Determination in fibrin from normals and factor XHI-deficient individuals, Ann. N.Y. Acad. Sci. 202:98 - 113.

    PubMed  CAS  Google Scholar 

  • Pletcher, C. H., and Nelsestuen, G. L., 1983, Two substrate reaction model for the heparin-catalyzed bovine antithrombin/protease reaction, J. Biol. Chem. 258:1086–1091.

    PubMed  CAS  Google Scholar 

  • Plummer, T. H., Jr., and Horwitz, M. Y., 1978, Human plasma carboxypeptidase N. Isolation and characterization, J. Biol. Chem. 253:3907–3912.

    CAS  Google Scholar 

  • Postlethwaite, A. E., and Kang, A. H., 1976, Collagen and collagen peptide induced chemotaxis of human blood monocytes, J. Exp. Med. 143:1299–1307.

    PubMed  CAS  Google Scholar 

  • Rankin, J. A., Hitchocck, M., Merrill, W. W., Huang, S. S., Brashler, J. R., Bach, M. K., and Askenase, P. W., 1984, IgE immune complexes induce immediate and prolonged release of leukotriene C4 (LTC4) from rat alveolar macrophages, J. Immunol. 132:1993–1999.

    PubMed  CAS  Google Scholar 

  • Ratnoff, O. D., and Cram, J. D., 1964, Activation of Hageman factor by solutions of ellagic acid, J. Lab. Clin. Med. 63:359–377.

    PubMed  CAS  Google Scholar 

  • Ratnoff, O. D., and Saito, H., 1979, Amidolytic properties of single-chain activated Hageman factor, Proc. Natl. Acad. Sci. U.S.A. 76:1461–1463.

    PubMed  CAS  Google Scholar 

  • Ratnoff, O. D., Davie, E. W., and Mallet, D. L., 1961, Studies on the action of Hageman factor. Evidence that activated Hageman factor in turn activates plasma thromboplastin antecedent, J. Clin. Invest. 40:803–819.

    PubMed  CAS  Google Scholar 

  • Revak, S. D., and Cochrane, C. G., 1976, The relationship of structure and function in human Hageman factor. The association of enzymatic and binding activities with separate regions of the molecule, J. Clin. Invest. 57:852–860.

    PubMed  CAS  Google Scholar 

  • Revak, S. D., Cochrane, C. G., and Griffin, J. H., 1977, The binding and cleavage characteristics of human Hageman factor during contact activation, J. Clin. Invest. 59:1167–1175.

    PubMed  CAS  Google Scholar 

  • Richardson, P. L., Pepper, D. S., and Kay, A. B., 1976, Chemotaxis for human monocytes by fibrinogen- derived peptides, Br. J. Haematol. 32:507–513.

    PubMed  CAS  Google Scholar 

  • Ridge, S. C., Oronsky, A. L., and Kerwar, S. S., 1980, Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages, Arthritis Rheum. 23:448–454.

    PubMed  CAS  Google Scholar 

  • Rijken, D. C., Wijngaards, G., Zaal-de Jong, M., and Wolbergen, J., 1979, Purification and partial characterization of plasminogen activator from human uterus tissue, Biochim. Biophys. Acta 580:140–153.

    PubMed  CAS  Google Scholar 

  • Robbins, K. C., Summaria, L., Hseih, B., and Shah, R., 1967, The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin, J. Biol. Chem. 242:2333–2342.

    PubMed  CAS  Google Scholar 

  • Roberts, L. J. II, Sweetman, B. J., Lewis, R. A., Austen, K. F., and Oates, J. A., 1980, Increased production of prostaglandin D2 in patients with systemic mastocytosis, N. Engl. J. Med. 303:1400–1404.

    PubMed  Google Scholar 

  • Rouzer, C. A., Scott, W. A., Hamill, A. L., and Cohn, Z. A., 1980, Dynamics of leukotriene C production by macrophages, J. Exp. Med. 152:1236–1247.

    PubMed  CAS  Google Scholar 

  • Saito, H., 1980, The participation of plasma thromboplastin antecedent (factor XI) in contact-activated fibrinolysis, Proc. Soc. Exp. Biol. Med. 164:153–157.

    PubMed  CAS  Google Scholar 

  • Saito, H., Ratnoff, O. D., and Donaldson, V. H., 1974, Defective activation of clotting, fibrinolytic, and permeability enhancing systems in human Fletcher trait plasma, Circ. Res. 34:641–651.

    PubMed  CAS  Google Scholar 

  • Salem, H. H., Esmon, N. L., Esmon, C. T., and Majerus, P. W., 1984, Effects of thrombomodalin and coagulation factor Va light chain on protein C activation in vitro, J. Clin. Invest. 73:968–972.

    CAS  Google Scholar 

  • Sanchez-Crespo, M., Alonso, F., and Egido, J., 1980, Platelet-activating factor in anaphylaxis and phagocytosis. I. Release from human peripheral polymorphonuclear and monocytes during the stimulation by ionophore A23187 and phagocytosis but not from degranulating basophils, Immunology 40:645–655.

    PubMed  CAS  Google Scholar 

  • Schapira, M., Despland, E., Scott, C. H., Boxer, L., and Colman, R. W., 1982a, Purified human plasma kallikrein aggregates human blood neutrophils, J. Clin. Invest. 69:1199–1202.

    PubMed  CAS  Google Scholar 

  • Schapira, M., Scott, C. F., and Colman, R. W., 1982b, Contribution of plasma protease inhibitors to the inactivation of kallikrein in plasma, J. Clin. Invest. 69:462–468.

    PubMed  CAS  Google Scholar 

  • Schapira, M., Scott, C. F., James, A., Silver, L. D., Kueppers, F., James, H. L., and Colman, R. W., 1982c, High molecular weight kininogen or its light chain protects human plasma kallikrein from inactivation by plasma protease inhibitors, Biochemistry 3:567–572.

    Google Scholar 

  • Schiffman, S., Mannhalter, C., and Tynerk, D., 1980, Human high molecular weight kininogen. Effects of cleavage by kallikrein on protein structural and procoagulant activity, J. Biol. Chem. 255:6433–6438.

    PubMed  CAS  Google Scholar 

  • Schreiber, A. D., and Frank, M. M., 1972, The role of antibody and complement in the clearance and destruction of erythrocytes. I. In vivo effects of IgG and IgM complement fixing sites, J. Clin. Invest. 51:575–582.

    PubMed  CAS  Google Scholar 

  • Schreiber, A. D., Kaplan, A. P., and Austen, K. F., 1973, Inhibition by Cl INH of Hageman factor fragment activation of coagulation, fibrinolysis, and kiningeneration, J. Clin. Invest. 52:1402–1409.

    PubMed  CAS  Google Scholar 

  • Schullek, J., Jordan, J., and Montgomery, R. R., 1984, Interaction of Von Willebrand factor with human platelets in the plasma milieu, J. Clin. Invest. 73:421–428.

    PubMed  CAS  Google Scholar 

  • Scicli, A. G., Mindroiu, T., Scicli, G., and Carretero, O. A., 1982, Blood kinins, their concentration in normal subjects and in patients with congenital deficiency in plasma prekallikrein and kininogen, J. Lab. Clin. Med. 100:81–93.

    PubMed  CAS  Google Scholar 

  • Scott, C. F., and Colman, R. W., 1980, Function and immunochemistry of prekallikreinhigh molecular weight kininogen complex in plasma, J. Clin. Invest. 656:413–421.

    Google Scholar 

  • Scott, C. F., Schapira, M., James, H. L., Cohen, A. B., and Colman, R. W., 1982, Inactivation of factor XIa by plasma protease inhibitors. Predominant role of α1 protease inhibitor and protective effect of high molecular weight kininogen, J. Clin. Invest. 69:844–852.

    PubMed  CAS  Google Scholar 

  • Scott, C. F., Silver, L. D., Purdon, A. D., and Colman, R. W., 1984a, Plasma Factor XIa regulates contact- activated coagulation, Fed. Proc. 43:775.

    Google Scholar 

  • Scott, C. F., Silver, L. D., Schapira, M., and Colman, R. W., 1984b, Cleavage of human high molecular weight kininogen markedly enhances its coagulant activity. Evidence that this molecule exists as a pro- cofactor, J. Clin. Invest. 73:954–962.

    PubMed  CAS  Google Scholar 

  • Sealey, J. E., Atlas, S. P., Laragh, J. H., Silverberg, M., and Kaplan, A. P., 1979, Initiation of plasma prorenin activation by Hageman factor dependent conversion of plasma prekallikrein to kallikrein, Proc. Natl. Acad. Sci. U.S.A. 76:5914–5918.

    PubMed  CAS  Google Scholar 

  • Senior, R. M., Griffin, G. L., and Mecham, R. P., 1980, Chemotactic activity of elastin derived peptides, J. Clin. Invest. 66:859–862.

    PubMed  CAS  Google Scholar 

  • Sharma, J. N., Zeitlin, I. J., Deodhar, S. D., and Buchanan, W. W., 1983, Arch. Int. Pharmacodyn. 262:279–286.

    PubMed  CAS  Google Scholar 

  • Shaw, J. O., Pinckard, R. N., Ferrigni, K. S., McManus, L. M., and Hanahan, D. J., 1981, Activation of human neutrophils with 1 -O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, the active moiety of platelet-activating factor, J. Immunol. 127:1250–1255.

    PubMed  CAS  Google Scholar 

  • Sheikh, I., and Kaplan, A. P., 1984, Assessment of kallidin, bradykinin, and bradykinin degradation products by high pressure liquid chromatography (HPLC), Fed. Proc. 44:1242 (abstract).

    Google Scholar 

  • Silverberg, M., and Kaplan, A. P., 1982b, Enzymatic activities of activated and zymogen form of human Hageman factor (factor XII) Blood 60:64–70.

    PubMed  CAS  Google Scholar 

  • Silverberg, M., Dunn, J. T., Garen, L., and Kaplan, A. P., 1980, Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate, J. Biol. Chem. 255:7281–7286.

    PubMed  CAS  Google Scholar 

  • Silverberg, M., Nicoll, J. E., and Kaplan, A. P., 1980, The mechanism by which the light chain of cleaved HMW-kininogen augments the activation of prekallikrein, factor XI, and Hageman factor, Thromb. Res. 70:173–189.

    Google Scholar 

  • Soter, N. A., Lewis, R. A., Corey, E. J., and Austen, K. F., 1983, Local effects of synthetic leucotrienes (LT C4, LT D4, LT E4, and LT B4) in human skin, J. Invest. Dermatol. 80:115–119.

    PubMed  CAS  Google Scholar 

  • Spragg, J., 1983, Characterization of purified human latent kallikrein, Kinins III, Adv. Exp. Med. Biol. 156:393–398.

    PubMed  CAS  Google Scholar 

  • Stead, N. W., Kaplan, A. P., and Rosenberg, R. D., 1976, The inhibition of human activated Hageman factor (HF) by human antithrombin-heparin cofactor (AT), J. Biol. Chem. 251:6481–6488.

    PubMed  CAS  Google Scholar 

  • Steinman, C. R., 1984, Circulating DNA in systemic lupus erythematosus. Isolation and characterization, J. Clin. Invest. 73:832–841.

    PubMed  CAS  Google Scholar 

  • Stenflo, J., 1976, A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization, J. Biol. Chem. 251:355–363.

    PubMed  CAS  Google Scholar 

  • Stenflo, J., Fernlund, P., Egan, W., and Roepstorff, P., 1974, Vitamin K dependent modifications of glutamic acid residues in prothrombin, Proc. Natl. Acad. Sci. U.S.A. 71:2730–2733.

    PubMed  CAS  Google Scholar 

  • Sueishi, K., Nanno, S., and Tanaka, K., 1981, Permeability enhancing and chemotactic activities of lower molecular weight degradation products of human fibrinogen, Thromb. Haemostas. 45:90–94.

    CAS  Google Scholar 

  • Summaria, L., Hsieh, B., Groskopf, W. R., and Robbins, K. C., 1967, The isolation and characterization of the S-carboxymethyl (3 (light) chain derivative of human plasmin. The localization of the active site on the p (light) chain, J. Biol Chem. 242:5046–5052.

    PubMed  CAS  Google Scholar 

  • Summaria, L., Arzadon, L., Bernabe, P., and Robbins, K. C., 1975, The activation of plasminogen by urokinase in the presence of the plasmin inhibitor trasylol. The preparation of plasmin with the same NH2-terminal heavy (A) chain sequence as the parent zymogen, J. Biol. Chem. 250:3486–3995.

    Google Scholar 

  • Takagi, T., and Doolittle, R. F., 1974, Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin, Biochemistry 13:750–756.

    PubMed  CAS  Google Scholar 

  • Talamo, R. C., Haber, E., and Austen, K. F., 1969, A radioimmunoassay for bradykinin in plasma and synovial fluid, J. Lab. Clin. Med. 74:816–827.

    PubMed  CAS  Google Scholar 

  • Tankersley, D. L., and Finlayson, J., 1984, Kinetics of activation and autoactivation of human factor XII, Biochemistry 23:273–279.

    PubMed  CAS  Google Scholar 

  • Tans, G., Rosny, J., and Griffin, J. H., 1983, Sulfatide-dependent autoactivation of human blood factor XII, (Hageman factor), J. Biol. Chem. 258:8215–8222.

    PubMed  CAS  Google Scholar 

  • Thompson, R. E., Mandle, R., Jr., and Kaplan, A. P., 1977, Association of factor XI and high molecular weight kininogen in human plasma, J. Clin. Invest. 60:1376–1380.

    PubMed  CAS  Google Scholar 

  • Thompson, R. E., Mandle, R., Jr., and Kaplan, A. P., 1978, Characterization of human HMW-kininogen. Procoagulant activity associated with the light chain of kinin-free HMW kininogen, J. Exp. Med. 147:488–499.

    PubMed  CAS  Google Scholar 

  • Thompson, R. E., Mandle, R., Jr., and Kaplan, A. P., 1979, Studies of the binding of prekallikrein and factor XI to high molecular weight kininogen and its light chain, Proc. Natl. Acad. Sci. U.S.A. 76:4862–4866.

    PubMed  CAS  Google Scholar 

  • Thorsen, S., Glas-Greenwalt, P., and Astrup, T., 1972, Difference in the binding to fibrin of urokinase and tissue plasminogen activator, Throm. Pathol Haemorrh. 28:65–74.

    CAS  Google Scholar 

  • Tollefson, D. M., Pestka, C. A., and Monafo, W. J., 1983, Activation of heparin cofactor II by dermatan sulfate, J. Biol Chem. 258:6713–6716.

    Google Scholar 

  • Ueno, A., Tanaka, K., Katori, M., Hayashi, M., and Arai, Y., 1981, Species differences in increased vascular permeability by synthetic leukotrienes C4 and D4, Prostaglandins 21:637–648.

    PubMed  CAS  Google Scholar 

  • Van der Graaf, F., Koedam, J. A., and Bouma, B. N., 1983a, Inactivation of kallikrein in human plasma, J. Clin. Invest. 71:149–158.

    PubMed  Google Scholar 

  • Van der Graaf, F., Koedam, J. A., Griffin, J. H., and Bouma, B. N., 1983b, Interaction of human plasma kallikrein and its light chain with CI– inhibitor, Biochemistry 22:4860–4866.

    PubMed  Google Scholar 

  • Vassalli, J. D., Hamilton, J., and Reich, E., 1976, Macrophage plasminogen activator modalation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides, Cell 8:271–281.

    PubMed  CAS  Google Scholar 

  • Vater, C. A., Nagase, H., and Harris, E. D., Jr., 1983, Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium, J. Biol. Chem. 258:9374–9382.

    PubMed  CAS  Google Scholar 

  • Verheyen, J. H., Chang, G. I. C., and Mullaart, E., 1983, Inhibition of extrinsic (tissue-type) plasminogen activator by human plasma:Evidence for the occurrence a fast-acting plasminogen activator inhibitor, Thromb. Haemostas. 50:294.

    Google Scholar 

  • Wachtfogel, Y. T., Kuchich, U., James, U. L., Scott, C. H., Schapira, M., Zimmerman, M., Cohen, A. B., and Colman, R. W., 1983, Human plasma kallikrein releases neutrophil elastase during blood coagulation, J. Clin. Invest. 72:1172–1677.

    Google Scholar 

  • Webster, M. E., and Pierce, J. V., 1963, The nature of kallidins released from human plasma by kallikreins and other enzymes, Ann. N.Y. Acad. Sci. 104:91–105.

    PubMed  CAS  Google Scholar 

  • Weinstein, M. J., and Chute, L. E., 1984, Two distinct forms of factor VIII coagulant protein in human plasma. Cleavage by thrombin and differences in coagulant activity and association with von Willebrand factor, J. Clin. Invest. 73:307–316.

    PubMed  CAS  Google Scholar 

  • Weiss, A. S., Gallin, J. I., and Kaplan, A. P., 1971, Fletcher factor deficiency. Abnormalities of coagulation, fibrinolysis, chemotactic activity, and kinin generation attributable to absence of prekallikrein, J. Clin. Invest. 53:622–633.

    Google Scholar 

  • Weiss, H. J., 1975, Platelet physiology and abnormalities of platelet function, N. Engl. J. Med. 293:531–544.

    PubMed  CAS  Google Scholar 

  • Weller, P. F., Lee, C. W., Foster, D. W., Corey, E. J., Austen, K. F., and Lewis, R. A., 1983, Generation and metabolism of 5 lipoxygenase pathway leucotrienes by human eosinophils predominant production of leucotriene C4, Proc. Natl. Acad. Sci. U.S.A. 80:7626–7630.

    PubMed  CAS  Google Scholar 

  • Werb, Z., Mainardi, C. L., Voter, C. A., and Harris, E. D., Jr., 1977, Endogenous activation of latent collagenase by rheumatoid synovial cells, N. Engl. J. Med. 296:1017–1023.

    PubMed  CAS  Google Scholar 

  • Wiggins, R. C., and Cochrane, C. G., 1979, The autoactivation of rabbit Hageman factor, J. Exp. Med. 150:1122–1133.

    PubMed  CAS  Google Scholar 

  • Wiggins, R. C., Bouma, B. N., Cochrane, C. G., and Griffin, J. H., 1977, Role of high molecular weight kininogen in surface-binding and activation of coagulation factor XI and prekallikrein, Proc. Natl. Acad. Sci. U.S.A. 74:4636–4640.

    PubMed  CAS  Google Scholar 

  • Williams, T. J., 1972, Prostaglandins E2, prostaglandin I2 and the vascular changes of inflammation, Br. J. Pharmacol. 65:517–524.

    Google Scholar 

  • Williams, T. J., and Peck, M. J., 1977, Role of prostaglandin-mediated vasodilatation in inflammation, Nature 270:530–532.

    PubMed  CAS  Google Scholar 

  • Wilner, G. D., Nossel, H. L., and LeRoy, E. C., 1968, Activation of Hageman factor by collagen, J. Clin. Invest. 47:2608–2615.

    PubMed  CAS  Google Scholar 

  • Wilson, J. G., Wong, W. W., Schur, P. H., and Fearon, D. T., 1982, Mode of inheritance of decreased C3b receptors on erythrocytes of patients with systemic lupus erythematosus, N. Engl. J. Med. 307:981–986.

    PubMed  CAS  Google Scholar 

  • Wiman, B., 1973, Primary structure of peptides released during activation of human plasminogen by urokinase, Eur. J. Biochem. 39:1–9.

    PubMed  CAS  Google Scholar 

  • Wuepper, K. D., 1973, Prekallikrein deficiency in man, J. Exp. Med. 138:1345–1355.

    PubMed  CAS  Google Scholar 

  • Wuepper, K. D., Miller, D. R., and LaCombe, M. J., 1975, Flaujeac trait. Deficiency of human plasma kininogen, J. Clin. Invest. 56:1663–1672.

    PubMed  CAS  Google Scholar 

  • Yecies, L. D., Wedner, H. J., and Parker, C. W., 1979, Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemia basophils. I. Evidence for a precursor role of arachidonic acid and initial characterization, J. Immunol. 123:2814–2816.

    PubMed  CAS  Google Scholar 

  • Zur, M., and Nemerson, Y., 1979, The esterase activity of coagulation factor VII. Evidence for intrinsic activity of the zymogen, J. Biol. Chem. 253:2203–2209.

    Google Scholar 

  • Zuraw, B. L., O’Hair, C. H., Vaughan, J. H., Mathison, D. A., Curd, J. G., and Katz, D. H., 1981, Immunoglobulin E-rheumatoid factor in the serum of patients with rheumatoid arthritis, asthma, and other diseases, J. Clin. Invest. 68:1610–1613.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Allergy, Rheumatology, and Clinical Immunology, Department of Medicine, The State University of New York at Stony Brook, Health Sciences Center, Stony Brook, New York, 11794, USA

    Allen P. Kaplan

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  1. Allen P. Kaplan
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  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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© 1985 Plenum Publishing Corporation

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Kaplan, A.P. (1985). Immune Complexes, Vasoactive Mediators, and Fibrinoid Necrosis in Connective Tissue Diseases. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_22

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  • DOI: https://doi.org/10.1007/978-1-4613-2493-5_22

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