Complement Components in Rheumatic Diseases

  • Peter H. Schur

Abstract

The complement system consists of a group of at least 18 serum proteins that interact sequentially to affect systems of inflammation (Fearon, 1981; Frank and Atkinson, 1975; Muller-Eberhard, 1974; Schur, 1977). Activation of complement is accompanied by a series of specific and limited enzymatic reactions that result in the cleavage of certain components, which subsequently generate new enzymatic activities and lead to the formation of complement complexes that have additional biological activities. Some of these activities are carried out on cells or immune complex surfaces and some in fluid; in some cases, other proteins inhibit these activities, at least in part.

Keywords

Arthritis Depression Anemia Osteoarthritis Malaria 

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Peter H. Schur
    • 1
  1. 1.Division of Rheumatology and ImmunologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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