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Antiphospholipid Antibodies

  • Chapter
Immunology of Rheumatic Diseases

Abstract

Of the several types of antibodies described in autoimmune disorders, the antiphospholipid antibodies have received relatively little attention. There are two well-described groups of antiphospholipid antibodies, anticardiolipin antibodies (Pangborn, 1941; De Bruijn, 1966; Inoue and Nojima, 1969; Harris et al., 1983, 1985c) and the lupus anticoagulant (Conley and Hartmann, 1952; Margolius et al., 1961; Feinstein and Rapaport, 1972; Veltkamp et al1974; Byron, 1982; Shapiro and Thiagarajan, 1982). Based on the demonstration of cross reactivity of some monoclonal DNA antibodies with cardiolipin and other phospholipids (Lafer et al., 1981; Schoenfeld et al., 1983; Koike et al., 1984a,b), it is believed by some investigators that a subgroup of anti-DNA antibodies may bind to the repeating phosphodiester groups on the polynucleotide backbone of DNA and that these antibodies, too, may be antiphospholipid antibodies.

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  1. Rheumatology Unit, Royal Postgraduate Medical School, The Hammersmith Hospital, London, W12 OHS, England

    G. R. V. Hughes, E. N. Harris & A. E. Gharavi

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  1. G. R. V. Hughes
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  2. E. N. Harris
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  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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Hughes, G.R.V., Harris, E.N., Gharavi, A.E. (1985). Antiphospholipid Antibodies. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_10

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