Abstract
Cytochrome P-450 is a group of nonspecific hydroxylating systems that hydroxylate substrates of widely varying structure (Ullrich, 1979). Cytochrome P-450 is important in the degradative hydroxylation of drugs in the body (Gillette et al., 1972). The enzyme can hydroxylate steroids and hydrocarbons. For example,Corynebacterium utilizes P-450 to oxidize n-octane to 1-octanol (Cardini and Justishuk, 1970), and fatty acids are hydroxylated at the ω and (ω-1) positions (Bjorkhem and Danielson, 1970; Ellinet al., 1972; Ichihara et al., 1979). Either cytochrome P-450 or similar iron-containing monooxygenases cleave inositol to n-glucuronic acid (Charalampous, 1959, 1960).
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© 1985 Plenum Press, New York
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Ingraham, L.L., Meyer, D.L. (1985). Cytochrome P-450. In: Biochemistry of Dioxygen. Biochemistry of the Elements, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2475-1_15
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