The Long-Lasting State of Specific Nonresponsiveness Induced By Intravenous Immunization with Alloantigens is Due to the Generation of Recirculating Suppressor T Cells
We investigated whether the long-lasting state of nonresponsiveness that is induced by intravenous immunization with alloantigens is mediated by suppressor T cells, or is caused by inactivation or deletion of the relevant alloreactive T cell clones. The data from parabiosis and thoracic duct drainage experiments suggest that the state of nonresponsiveness depends on recirculating non-proliferating Ts memory cells.
KeywordsSpleen Cell Thoracic Duct Delay Type Hypersensitivity Naive Mouse Delay Type Hypersensitivity Response
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