The Long-Lasting State of Specific Nonresponsiveness Induced By Intravenous Immunization with Alloantigens is Due to the Generation of Recirculating Suppressor T Cells
We investigated whether the long-lasting state of nonresponsiveness that is induced by intravenous immunization with alloantigens is mediated by suppressor T cells, or is caused by inactivation or deletion of the relevant alloreactive T cell clones. The data from parabiosis and thoracic duct drainage experiments suggest that the state of nonresponsiveness depends on recirculating non-proliferating Ts memory cells.
KeywordsMigration Heparin Vinblastine DNFB
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- 1.M.I. Greene and B. Benacerraf, Studies on hapten specific T cell immunity and suppression. Immunol. Rev. 50: 163 (1980).Google Scholar
- 2.I.A. Ramshaw, P.A. Bretscher, and C.R. Parish, Regulation of the immune response. I. uppression of delayed-type-hyper- sensitivity by T cells from mice expressing humoral immunity. Eur. J. Immunol. 6: 674 (1976).Google Scholar
- 3.F.Y. Liew and J.G. Howard, Regulation of delayed-type-hyper-sensitivity. V. Suppressor cell memory in antigen-specific suppression of delayed-type hypersensitivity to sheep erythrocytes. Eur. J. Immunol. 10: 937 (1980).Google Scholar
- 7.A.T.J. Bianchi, L.M. Hussaarts-Odijk, E.A.J. Wolters, and R. Benner, Suppression of antigraft immunity by preimmunization. III. Characterization of the suppressor T cells involved in suppression of the efferent phase of DTH against alloantigens. Submitted for publication.Google Scholar
- 10.S.H.E. Kaufmann, J.S. Ahmed, and H. Hahn. Transferable suppression and intrinsic unresponsiveness in delayed-type hypersensitivity to sheep red blood cells of mice: two distinct mechanisms? Immunobiol. 157: 331 (1980).Google Scholar
- 13.R. Benner, A. van Oudenaren, and H. de Ruiter, Antibody formation in mouse bone marrow. VII. Evidence against the migration of plaque-forming cells as the underlying cause for bone marrow plaque-forming cell activity: a study with parabiotic mice. Cell. Immunol. 29: 28 (1977).Google Scholar
- 14.R. Benner, A. van Oudenaren, and H. de Ruiter, Antibody formation in mouse bone marrow. VII. Evidence against the migration of plaque-forming cells as the underlying cause for bone marrow plaque-forming cell activity: a study with parabiotic mice. Cell. Immunol. 29: 28 (1977).Google Scholar
- 16.L. Tolak and C. Rinck, Persistent activity of suppressor cells in T cell-mediated immune response. J. Immunol. 121: 762 (1978).Google Scholar
- 18.A.T.J. Bianchi, H. de Ruiter, L.M. Hussaarts-Odijk, and R. Benner, Secondary delayed-type hypersensitivity to sheep red blood cells and minor histocompatibility antigens in mice: transfer of memory by recirculating thoracic duct lymphocytes. Immunobiol. 165: 200 (1983).Google Scholar