Summary
We investigated whether the long-lasting state of nonresponsiveness that is induced by intravenous immunization with alloantigens is mediated by suppressor T cells, or is caused by inactivation or deletion of the relevant alloreactive T cell clones. The data from parabiosis and thoracic duct drainage experiments suggest that the state of nonresponsiveness depends on recirculating non-proliferating Ts memory cells.
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Bianchi, A.T.J., Hussaarts-Odijk, L.M., Bril, H., de Ruiter, H., Benner, R. (1985). The Long-Lasting State of Specific Nonresponsiveness Induced By Intravenous Immunization with Alloantigens is Due to the Generation of Recirculating Suppressor T Cells. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_64
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DOI: https://doi.org/10.1007/978-1-4613-2463-8_64
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