T-Lymphocytes in Rat Lymphoid Follicles are a Subset of T Helper Cells

  • F. G. M. Kroese
  • A. S. Wubbena
  • P. Joling
  • P. Nieuwenhuis


Germinal centres are well defined morphological structures found in peripheral lymphoid organs upon stimulation with antigen (for review see 1). Although their role in the generation of immunological memory seems to be well established, the mechanism of germinal centre reactivity is hardly understood. However, it is clear that T-lymphocytes play an important role in their generation, as indicated by the absence of germinal centres in nude (thymusless) animals (2). Moreover, reconstitution of lethally irradiated mice and rats requires both B and T-lymphocytes for germinal centres to develop (3) and T-independent antigens are poor inducers of germinal centre activity (4).


Natural Killer Cell Germinal Centre Lymphoid Follicle Splenic Tissue Primary Follicle 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • F. G. M. Kroese
    • 1
  • A. S. Wubbena
    • 1
  • P. Joling
    • 1
    • 2
  • P. Nieuwenhuis
    • 1
  1. 1.Dept. of HistologyState UniversityGroningenThe Netherlands
  2. 2.Dept. of Internal Medicine IErasmus UniversityRotterdamThe Netherlands

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