Abstract
The dendritic cell is a recently recognized new cell type having important immunological functions. It provides accessory activity required for responses of T lymphocytes, acts as a potent stimulator of a mixed leukocyte reaction and, owing to its richness in Ia antigens, serves as a critical “passenger cell” that elicits rejection of transplanted tissues. In rat, the dendritic cell is the principal accessory cell required for proliferation of Tx lymphocytes induced by treatment with sodium periodate. As measured by 3H-thymidine incorporation, proliferation shows a linear dose-response with the addition of dendritic cells, which provided a useful assay.
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References
Klinkert, W.E.F., LaBadie, J.H., O’Brien, J.P., Beyer, C.F., and Bowers, W.E., 1980, Rat Dendritic Cells Function as Accessory Cells and Control the Production of a Soluble Factor Required for Mitogenic Responses of T Lymphocytes, Proc. Natl. Acad. Sci, USA, 77:5414.
Klinkert, W.E.F., LaBadie, J.H., and Bowers, W.E., 1982, Accessory and Stimulating Properties of Dendritic Cells and Macrophages Isolated From Various Rat Tissues, J. Exp. Med., 156:1
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© 1985 Plenum Press, New York
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Bowers, W.E., Berkowitz, M.R. (1985). Development of Dendritic Cells from Rat Bone Marrow. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_45
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DOI: https://doi.org/10.1007/978-1-4613-2463-8_45
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9495-5
Online ISBN: 978-1-4613-2463-8
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