Antibody Responses to T-Dependent Antigens: Contributions of Dendritic Cells and Helper T Lymphocytes

  • Kayo Inaba
  • Ralph M. Steinman


The standard system for the study of antigen-specific, thymus dependent, antibody responses utilizes mouse spleen. B and T lymphocytes (Sephadex G10 nonadherent spleen) are cultured with accessory cells (plastic adherent spleen) and antigen (red cells or TNP/DNP-KLH) for 4-5 days to generate specific IgM PFC. The accessory cells likely induce functioning helper T cells, and the latter cooperate with B lymphocytes during antibody formation.


Dendritic Cell Antibody Response Helper Cell Accessory Cell Peripheral Lymphoid Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



dendritic cell


plaque forming cell


keyhole limpet hemocyanin


mixed leukocyte reaction


major histocompatibility complex




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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Kayo Inaba
    • 1
  • Ralph M. Steinman
    • 1
  1. 1.The Rockefeller University and Irvington House InstituteNew YorkUSA

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