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Heterogeneity of Human Thymus Epithelial Cells Revealed by Monoclonal Anti-Epithelial Cell Antibodies

  • Mary A. Ritter
  • Henk-Jan Schuurman
  • Wilma A. MacKenzie
  • Ruud A. de Maagd
  • Kevin M. Price
  • Roel Broekhuizen
  • Louis Kater

Abstract

The epithelial cell matrix of the thymus, which is involved in the generation of T lymphocyte immunocompetence, shows considerable (cytological) heterogeneity. This phenomenon has been well-established in ultrastructural morphology (this issue, p 288),2 but also in expression of thymic hormone components in the cytoplasm.3 We started the analysis of the thymic microenvironment for antigenic heterogeneity by raising monoclonal antibodies to thymus stromal cells.

Keywords

Bordetella Pertussis Freeze Tissue Section Human Thymus Thymus Stromal Cell Royal Postgraduate Medical School 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Mary A. Ritter
    • 1
    • 2
  • Henk-Jan Schuurman
    • 1
    • 2
  • Wilma A. MacKenzie
    • 1
    • 2
  • Ruud A. de Maagd
    • 1
    • 2
  • Kevin M. Price
    • 1
    • 2
  • Roel Broekhuizen
    • 1
    • 2
  • Louis Kater
    • 1
    • 2
  1. 1.Department of ImmunologyRoyal Postgraduate Medical School, Hammersmith HospitalLondonEngland
  2. 2.Division of Immunopathology, Departments of Internal Medicine and PathologyUniversity HospitalUtrechtThe Netherlands

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