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Heterogeneity of Human Thymus Epithelial Cells Revealed by Monoclonal Anti-Epithelial Cell Antibodies

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Microenvironments in the Lymphoid System

Abstract

The epithelial cell matrix of the thymus, which is involved in the generation of T lymphocyte immunocompetence, shows considerable (cytological) heterogeneity. This phenomenon has been well-established in ultrastructural morphology (this issue, p 288),2 but also in expression of thymic hormone components in the cytoplasm.3 We started the analysis of the thymic microenvironment for antigenic heterogeneity by raising monoclonal antibodies to thymus stromal cells.

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References

  1. G. Janossy, M. Bofill, L.K. Trejdosiewicz, and M. Chilosi, Cellular differentiation of lymphoid subpopulations and their microenvironments in the human thymus, in: “The thymus, histophysiology and pathology,” H.K. Muller-Hermelink, ed., Springer Verlag, Berlin (1984).

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  2. F.P. van de Wijngaert, M.D. Kendall, H.-J. Schuurman, L.H.P.M. Rademakers, and L. Kater, Heterogeneity of epithelial cells in the human thymus. An ultrastructural study, Cell Tissue Res. 237: 227 (1984).

    Article  PubMed  Google Scholar 

  3. H.J. Schuurman, F.P. van de Wijngaert, L. Delvoye, R. Broekhuizen, J.E. McClure, A.L. Goldstein, and L. Kater, Heterogeneity and age dependency of human thymus reticulo-epithelium in production of thymosin components, Thymus in press

    Google Scholar 

  4. F.P. van de Wijngaert, L.H.P.M. Rademakers, H.J. Schuurman, R.A. de Weger, and L. Kater, Identification and in situ localization of the “Thymic Nurse Cell” in man, J. Immunol 130: 2348 (1983).

    PubMed  Google Scholar 

  5. M.A. Ritter, C.A. Sauvage, and S.F. Cotmore, The human thymus microenvironment: in vivo identification of thymic nurse cells and other antigenetically distinct subpopulations of epithelial cells, Immunology 44: 439 (1981).

    PubMed  CAS  Google Scholar 

  6. B.F. Haynes, R.M. Scearce, D.F. Lobach, and L.L. Hensley, Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment, J. exp. Med 159: 1149 (1984)

    CAS  Google Scholar 

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© 1985 Plenum Press, New York

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Ritter, M.A. et al. (1985). Heterogeneity of Human Thymus Epithelial Cells Revealed by Monoclonal Anti-Epithelial Cell Antibodies. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_34

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  • DOI: https://doi.org/10.1007/978-1-4613-2463-8_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9495-5

  • Online ISBN: 978-1-4613-2463-8

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