Evidence of Differences Between Peyer’s Patches and Germinal Centers

  • John D. Reynolds


Ever since the first description of Peyer’s patches (PP), which was probably by Marco Severino in his treatise on comparative anatomy published in 1645 (cited by Schmidt, 1959), there have been changing views on the function of these lymphoid tissues found along the intestinal tract. The first detailed study by Peyer (1677) led to the concept, which survived for almost 2 centuries, that PP were involved in mucous secretion. The attention of the microscopists in the second half of the 19th century, however, correctly identified PP as sites where lymphocytes are being produced. In 1851 Bruecke described the “milky white area” which was the follicle filled with lymphocytes. In 1862 His described what he called “vacuoles” in the lymph nodes which appeared to be similar to the follicles in the PP. Then in 1885 Flemming noted that these areas in the lymph nodes and the PP were both sites of high mitotic activity. He coined the term “germinal center” (GC) and correctly suggested that they are breeding sites of lymphocytes.


Lymphoid Tissue Lymphoid Organ Proliferate Lymphocyte Mesenteric Lymph Node High Mitotic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John D. Reynolds
    • 1
  1. 1.Department of Medical PhysiologyThe University of CalgaryCalgaryCanada

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