Evidence of Differences Between Peyer’s Patches and Germinal Centers
Ever since the first description of Peyer’s patches (PP), which was probably by Marco Severino in his treatise on comparative anatomy published in 1645 (cited by Schmidt, 1959), there have been changing views on the function of these lymphoid tissues found along the intestinal tract. The first detailed study by Peyer (1677) led to the concept, which survived for almost 2 centuries, that PP were involved in mucous secretion. The attention of the microscopists in the second half of the 19th century, however, correctly identified PP as sites where lymphocytes are being produced. In 1851 Bruecke described the “milky white area” which was the follicle filled with lymphocytes. In 1862 His described what he called “vacuoles” in the lymph nodes which appeared to be similar to the follicles in the PP. Then in 1885 Flemming noted that these areas in the lymph nodes and the PP were both sites of high mitotic activity. He coined the term “germinal center” (GC) and correctly suggested that they are breeding sites of lymphocytes.
KeywordsGerminal Paraffin Methacrylate Ferritin Ileal
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- Brambell, F.W.R., 1970, “The Transmission of Passive Immunity from Mother to Young,” North-Holland Publ. Co., Amsterdam.Google Scholar
- Bruecke, E., 1851, Ueber den Bau und die Physiologische Bedeutung der Peyerischen Druesen. Denkschriften der kaiserlichen Akademie der Wissenschaften. Wein, 2:21.Google Scholar
- Cebra, J.J., Fuhrman, J.A., Gearhart, P.J., Hurwitz, J.L., and Shahin, R.D., 1982, B lymphocyte differentiation leading to a commitment to IgA expression may depend on cell division and may occur during antigen-stimulated clonal expansion, in: “Recent Advances in Mucosal Immunity,” W. Strober, L.A, Hanson, and K.W. Sell, eds, Raven Press, New York.Google Scholar
- Hellman, T., 1943, Lymphgefaesze, Lymphknoetchen und Lymphknoten. Handbuch f. d. Mik. Anat. d. Menschen, 6 /1:233.Google Scholar
- His, W., 1860–1862, Beitraege zur Kenntnis der zum Lymphsystem gehoerigen Druesen., Zeitschr. Wiss. Zool., 10:333, 11:65.Google Scholar
- Nieuwenhuis, P., Gastkemper, N.A., and Opstelten, D., 1981, Histo-physiology of follicular structures and germinal centres in relation to B cell differentiation, in: “Ciba Foundation Symposium” 84:246, Pitman, London.Google Scholar
- Peyer, J.C., 1677, “Exercitatio anat. de glandulis intestinorum earumque usu et affectionibus,” Schaffhausen.Google Scholar
- Reynolds, J.D., 1976, “The Development and Physiology of the Gut-Associated Lymphoid Tissues in Lambs” Ph.D. thesis, Australian National University.Google Scholar
- Schmidt, J.E., 1959, “Medical Discoveries,” Charles C. Thomas, Springfield. Google Scholar
- Silverstein, A.M., and Prendergast, R.A., 1971, The maturation of lymphoid tissue structure and function in ontogeny. Adv. Exp. Med. Biol., 29:383.Google Scholar