A Study of Lymph Node Lymphocytes in Rheumatoid Arthritis

  • Deborah Symmons
  • P. A. Bacon
  • M. Salmon
  • A. D. Blann


The role of lymphocytes in the pathogenesis of rheumatoid arthritis (RA) remains controversial. Patients with RA have increased levels of circulating activated lymphocytes, the levels of which correlate with the degree of active synovitis (1,2). It is not known whether these circulating lymphocytes are a spillover from the rheumatoid synovium, which contains lymphocytic infiltrates and follicles (3), or whether the lymphocytes are activated elsewhere and then migrate to the synovium, as the thoracic duct drainage experiments suggest (4).


Rheumatoid Arthritis Rheumatoid Arthritis Patient Thymidine Uptake Rheumatoid Synovium Sinus Histiocytosis 
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  1. 1.
    Bacon PA, Sewell RL and Crowther D. Reactive lymphoid cells (immunoblasts) in autoimmune and haemotological disorders. Clin. Exp. Immunol. (1975) 19: 201–8.PubMedGoogle Scholar
  2. 2.
    Alexander GJM, Bacon PA, Cavalcanti F, Blake DR and Hall ND. Low density lymphocytes: their relationship to disease activity and to anti-rheumatic therapy. Br. J. Rheum. (1984) 23: 6–14.CrossRefGoogle Scholar
  3. 3.
    Gardner DL. Pathology of rheumatoid arthritis in Copeman’s Textbook of the Rheumatic Diseases (1978). Ed. J T Scott p. 277–278.Google Scholar
  4. 4.
    Paulus HE, Machleder HI, Levine S, Yu DTY and MacDonald DS. Lymphocyte involvement in rheumatoid arthritis. Arthr. Rheum. (1977) 20: 1249–62.CrossRefGoogle Scholar
  5. 5.
    Robertson MDJ, Hart FD, White WF, Nuki G and Boardman P. Rheumatoid lymphadenopathy. Ann. Rheum. Dis. (1968) 27: 253–260.PubMedCrossRefGoogle Scholar
  6. 6.
    Cruikshank B. Lesions of lymph nodes in rheumatoid disease and in disseminated lupus erythematosus. Scot. Med. J. (1958)3: 110–119.Google Scholar
  7. 7.
    Park WM and Ward DJ. An evaluation of rheumatoid lymphadenopathy by follow-up lymphography. Proc. 2nd Congress Eur. Assn. Radiol. (1971) 225–230.Google Scholar
  8. 8.
    Salmon M, Bacon PA, Johnson GD, Walker L and Walton KW. The use of cytocentrifuge preparations for the demonstration of T cell surface antigens. J. Imm. Meths. (1984) 66: 327–330.CrossRefGoogle Scholar
  9. 9.
    Carter SD, Bacon PA and Hall ND. Characteristics of activated lymphocytes in the peripheral blood of patients with rheumatoid arthritis. Ann. Rheum. Dis. (1981) 40: 293–298.PubMedCrossRefGoogle Scholar
  10. 10.
    Hall JG and Morris B. The output of cells in lymph from the popliteal node of sheep. Quart. J. Exp. Physiol. (1962) 47: 360–369.PubMedGoogle Scholar
  11. 11.
    Galbraith G, Galbraith R and Page Faulk W. Transferrin binding by human lymphoblastoid cell lines and other transformed cells. Cell Immunol. (1980) 49: 215–222.PubMedCrossRefGoogle Scholar
  12. 12.
    Bacon PA, Alexander GJM, Lever J and Elson C. Activated lymphocytes in lymph nodes, blood and synovial fluid in RA. Revue de Rhum. (1981) Numéro Spécial Abstract 0590Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Deborah Symmons
    • 1
  • P. A. Bacon
    • 1
  • M. Salmon
    • 1
  • A. D. Blann
    • 1
  1. 1.Rheumatism Research WingThe Medical SchoolBirminghamUK

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