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The Origin of B-Chronic Lymphocytic Leukaemia (B-CLL) and its Relationship to Hairy Cell Leukaemia (HCL)

  • F. Caligaris-Cappio
  • L. Bergui
  • G. Pizzolo
  • M. Chilosi
  • L. Tesio
  • D. Campana
  • G. Semenzato
  • F. Malavasi
  • M. Gobbi

Abstract

B-CLL is the prototype of B-cell chronic lymphoid leukaemias. The malignant cells have well defined features such as weak surface immunoglobulins (sIg), rosetting ability with Mouse red blood cells (Mrbc) and expression of the T-cell associated antigen TI (reviewed in ref. 1). HCL is an enigmatic disorder classified, in its typical form, among chronic B-cell malignancies. The leukaemic cells express monoclonal sIg 2,3 and exhibit the appropriate Ig gene rearrangement 4. Unique to HCL is the concomitant presence of four major characters: a) typical membrane irregularities with veils and microprocesses 5,6; b) strong cytoplasmic tartrate resistant acid phosphatase (TRAP) activity 5,6; c) positivity with the monoclonal antibody (Mc7Ab) SHCL3 which is negative on non-Hodgkin’s lymphomas and B-CLL 7; d) membrane reactivity with the Mc Ab anti-Tac 4,8 which detects the receptor for Interleukin 2 (IL 2; ref. 9).

Keywords

Chronic Lymphocytic Leukemia Tartrate Resistant Acid Phospha Hairy Cell Leukaemia Chronic Lymphocytic Leukemia Cell Hairy Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • F. Caligaris-Cappio
    • 1
  • L. Bergui
    • 1
  • G. Pizzolo
    • 2
  • M. Chilosi
    • 2
  • L. Tesio
    • 1
  • D. Campana
    • 1
  • G. Semenzato
    • 3
  • F. Malavasi
    • 4
  • M. Gobbi
    • 5
  1. 1.Cattedra Clinica Medica AUniversità di TorinoItaly
  2. 2.Catt. Ematologia e Anatomia PatologicaUniversità di VeronaItaly
  3. 3.Cattedra Clinica MedicaUniversità di PadovaItaly
  4. 4.Cattedra Genetica MedicaUniversità di TorinoItaly
  5. 5.Ist. Ematologia L. & A. SeragnoliUniversità di BolognaItaly

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