Abstract
The plasma lipoproteins can be divided into three major classes based upon their size, structure, density and function. Each of these classes plays an important role in the balance of vascular and intracellular lipid synthesis. In our study of relationship between lipoprotein composition and structure and the dynamics of lipid and protein transport among lipoproteins and cells, we have noted a number of correlations between lipoprotein structure and the transfer of lipoprotein components, within the lipoprotein or to cell membranes. Much of this discussion will focus upon the high- density lipoproteins (HDL), since their structure and properties have been relatively amenable to scientific probes. It is hoped that these studies will be useful in understanding the properties and behavior of the other lipoproteins.
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H. J. Pownall, Q. Pao, M. Rohde, and A. M. Gotto, Jr., Biochem. Biophys. Res. Comm. 85: 408 – 414 (1978).
H. J. Pownall, D. L. Hickson, and A. M. Gotto, Jr., J. Biol. Chem. 256: 9849 – 9854 (1981).
H. J. Pownall, Q. Pao, D. L. Hickson, J. T. Sparrow, and A. M. Gotto, Jr., Biophys. J. 37: 175 – 176 (1982).
M. E. Haberland and J. A. Reynolds, J. Biol. Chem. 250: 6636 – 6639 (1975).
R. Smith and C. Tanford, J. Mol. Biol. 67 – 75 (1972).
M. E. Haberland and J. A. Reynolds, Fed. Proc. 32: 639 (abs.) (1973).
J. C. Osborne and H. B. Brewer, Adv. Protein Chem. 31: 253 – 231 (1977).
C. Tanford, “The Hydrophobic Effect,” Second Edition, Wiley Interscience, New York (1980).
J. P. Segrest, R. L. Jackson, J. P. Morrisett, and A. M. Gotto, Jr., FEBS Lett. 38: 247 – 258 (1974).
H. J. Pownall, D. L. Hickson, and A. M. Gotto, Jr., J. Biol. Chem. 256: 9849 – 9854 (1981).
D. Eisenberg, R. M. Weiss, and T. C. Terwilliger, Nature 299: 371 – 374 (1982).
M. Levitt, J. Mol. Biol. 104: 59 – 107 (1976).
J. T. Sparrow and A. M. Gotto, Jr., Ann. N.Y. Acad. Sci. 348: 187 – 208 (1980).
J. T. Sparrow, J. D. Morrisett, H. J. Pownall: Chemistry, Structure and Biology, Proc. 4th Am. Peptide Symp., in: “Ann Arbor Science,” R. Walter and J. Meienhofer, eds., pp. 597 – 602, Ann Arbor, Michigan (1975).
F. J. Martin and R. C. McDonald, Biochemistry 15: 321 – 327 (1976)
H. J. Pownall, D. L. Hickson, and L. C. Smith, J. Amer. Chem. Soc. 105: 2440 – 2445 (1983).
S. Mishkin and R. Turcotte, Biochem. Biophys. Res. Comm. 60: 376 381 (1974).
D. B. Zilversmit, L. B. Hughes, and J. Palmer, J. Biochim. Biophys. Acta 409: 393 – 398 (1978).
K. W. A. Wirtz, H. H. Kamp, and L. L. M. Van Deene, Biochim. Biophys. Acta 274: 606 – 617 (1972).
L. R. McLean and M. C. Phillips, Biochemistry 20: 2893 (1981).
M. C. Doody, H. J. Pownall, Y. J. Kao, and L. C. Smith, Biochemistry 19: 108 – 116 (1980).
J. B. Massey, A. M. Gotto, Jr., and H. J. Pownall, Biochemistry, 21: 3630 – 3636 (1982).
P. Wolkowicz, H. J. Pownall, and J. McMillan-Wood, unpublished.
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© 1985 Plenum Press, New York
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Pownall, H.J., Gotto, A.M. (1985). The Role of Hydrophobicity in the Structure of the Human Plasma Lipoproteins. In: Kritchevsky, D., Holmes, W.L., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism VIII. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2459-1_7
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DOI: https://doi.org/10.1007/978-1-4613-2459-1_7
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