Skip to main content

The Role of Hydrophobicity in the Structure of the Human Plasma Lipoproteins

  • Chapter
Drugs Affecting Lipid Metabolism VIII

Abstract

The plasma lipoproteins can be divided into three major classes based upon their size, structure, density and function. Each of these classes plays an important role in the balance of vascular and intracellular lipid synthesis. In our study of relationship between lipoprotein composition and structure and the dynamics of lipid and protein transport among lipoproteins and cells, we have noted a number of correlations between lipoprotein structure and the transfer of lipoprotein components, within the lipoprotein or to cell membranes. Much of this discussion will focus upon the high- density lipoproteins (HDL), since their structure and properties have been relatively amenable to scientific probes. It is hoped that these studies will be useful in understanding the properties and behavior of the other lipoproteins.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H. J. Pownall, Q. Pao, M. Rohde, and A. M. Gotto, Jr., Biochem. Biophys. Res. Comm. 85: 408 – 414 (1978).

    Article  PubMed  CAS  Google Scholar 

  2. H. J. Pownall, D. L. Hickson, and A. M. Gotto, Jr., J. Biol. Chem. 256: 9849 – 9854 (1981).

    PubMed  CAS  Google Scholar 

  3. H. J. Pownall, Q. Pao, D. L. Hickson, J. T. Sparrow, and A. M. Gotto, Jr., Biophys. J. 37: 175 – 176 (1982).

    Article  PubMed  CAS  Google Scholar 

  4. M. E. Haberland and J. A. Reynolds, J. Biol. Chem. 250: 6636 – 6639 (1975).

    PubMed  CAS  Google Scholar 

  5. R. Smith and C. Tanford, J. Mol. Biol. 67 – 75 (1972).

    Google Scholar 

  6. M. E. Haberland and J. A. Reynolds, Fed. Proc. 32: 639 (abs.) (1973).

    Google Scholar 

  7. J. C. Osborne and H. B. Brewer, Adv. Protein Chem. 31: 253 – 231 (1977).

    Article  PubMed  CAS  Google Scholar 

  8. C. Tanford, “The Hydrophobic Effect,” Second Edition, Wiley Interscience, New York (1980).

    Google Scholar 

  9. J. P. Segrest, R. L. Jackson, J. P. Morrisett, and A. M. Gotto, Jr., FEBS Lett. 38: 247 – 258 (1974).

    Article  PubMed  CAS  Google Scholar 

  10. H. J. Pownall, D. L. Hickson, and A. M. Gotto, Jr., J. Biol. Chem. 256: 9849 – 9854 (1981).

    PubMed  CAS  Google Scholar 

  11. D. Eisenberg, R. M. Weiss, and T. C. Terwilliger, Nature 299: 371 – 374 (1982).

    Article  PubMed  CAS  Google Scholar 

  12. M. Levitt, J. Mol. Biol. 104: 59 – 107 (1976).

    Article  PubMed  CAS  Google Scholar 

  13. J. T. Sparrow and A. M. Gotto, Jr., Ann. N.Y. Acad. Sci. 348: 187 – 208 (1980).

    Article  PubMed  CAS  Google Scholar 

  14. J. T. Sparrow, J. D. Morrisett, H. J. Pownall: Chemistry, Structure and Biology, Proc. 4th Am. Peptide Symp., in: “Ann Arbor Science,” R. Walter and J. Meienhofer, eds., pp. 597 – 602, Ann Arbor, Michigan (1975).

    Google Scholar 

  15. F. J. Martin and R. C. McDonald, Biochemistry 15: 321 – 327 (1976)

    Article  PubMed  CAS  Google Scholar 

  16. H. J. Pownall, D. L. Hickson, and L. C. Smith, J. Amer. Chem. Soc. 105: 2440 – 2445 (1983).

    Article  CAS  Google Scholar 

  17. S. Mishkin and R. Turcotte, Biochem. Biophys. Res. Comm. 60: 376 381 (1974).

    Google Scholar 

  18. D. B. Zilversmit, L. B. Hughes, and J. Palmer, J. Biochim. Biophys. Acta 409: 393 – 398 (1978).

    Google Scholar 

  19. K. W. A. Wirtz, H. H. Kamp, and L. L. M. Van Deene, Biochim. Biophys. Acta 274: 606 – 617 (1972).

    Article  PubMed  CAS  Google Scholar 

  20. L. R. McLean and M. C. Phillips, Biochemistry 20: 2893 (1981).

    Article  PubMed  CAS  Google Scholar 

  21. M. C. Doody, H. J. Pownall, Y. J. Kao, and L. C. Smith, Biochemistry 19: 108 – 116 (1980).

    Article  PubMed  CAS  Google Scholar 

  22. J. B. Massey, A. M. Gotto, Jr., and H. J. Pownall, Biochemistry, 21: 3630 – 3636 (1982).

    Article  PubMed  CAS  Google Scholar 

  23. P. Wolkowicz, H. J. Pownall, and J. McMillan-Wood, unpublished.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Pownall, H.J., Gotto, A.M. (1985). The Role of Hydrophobicity in the Structure of the Human Plasma Lipoproteins. In: Kritchevsky, D., Holmes, W.L., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism VIII. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2459-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2459-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9493-1

  • Online ISBN: 978-1-4613-2459-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics