Skip to main content
SpringerLink
Log in

Hypertriglyceridemia: Lipoprotein Receptors and Atherosclerosis

  • Chapter
Book cover Drugs Affecting Lipid Metabolism VIII

  • 74 Accesses

Abstract

Some forms of atherosclerosis appear to be related to abnormalities in the metabolism of lipoproteins containing apoB and/or apoE. The uptake of these lipoproteins by specific lipoprotein receptors may be involved in atherogenesis. In Houston, we have been particularly interested in the abnormal receptor-mediated cellular uptake of very low density lipoproteins (VLDL) from subjects with hypertriglyceridemia that appears to account for certain VLDL catabolic abnormalties and may be involved in atherogenesis in these subjects.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. L. Goldstein and M. S. Brown, Ann. Rev. Biochem. 46: 897 – 930 (1977).

    Article  PubMed  CAS  Google Scholar 

  2. M. S. Brown and J. L. Goldstein, Ann. Rev. Biochem. 52: 223 – 61 (1983).

    Article  PubMed  CAS  Google Scholar 

  3. R.W. Mahley and T. L. Innerarity, Biochim. Biophy. Acta 737: 197 – 222 (1983).

    CAS  Google Scholar 

  4. S. H. Gianturco, A. M. Gotto, Jr., R. L. Jackson, J. R. Patsch, H. D. Sybers, O. D. Taunton, D. L. Yeshurun, and L. C. Smith J. Clin. Invest. 61: 320 – 328 (1978).

    Article  PubMed  CAS  Google Scholar 

  5. A. Poyser and P. J. Nestel, Artery 6: 122 – 143 (1979).

    CAS  Google Scholar 

  6. S. H. Gianturco, C. J. Packard, J. Shepherd, L. C. Smith, A. L. Catapano, H. D. Sybers, and A. M. Gotto, Jr., Lipids15:456– 463 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. S. H. Gianturco, F. B. Brown, A. M. Gotto, Jr., and W. A. Bradley, J. Lipid Research 23: 984 – 993 (1982).

    CAS  Google Scholar 

  8. S. H. Gianturco, W. A. Bradley, A. M. Gotto, Jr., J. D. Morrisett, and D. L. Peavy, J. Clin. Invest. 70: 168 – 178 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. S. H. Gianturco, S. G. Eskin, L. T. Navarro, C. J. Lahart, L. C. Smith, and A. M. Gotto, Jr., Biochim. Biophys. Acta 618: 143 – 152 (1980).

    PubMed  CAS  Google Scholar 

  10. J. F. Reardon, N. H. Fidge, and P. J. Nestel, J. Clin. Invest. 61: 850 – 860 (1978).

    Article  PubMed  CAS  Google Scholar 

  11. D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, in: “The Metabolic Basis of Inherited Diseases,” J. G. Stanbury, M. F Wyngaarden, and D. S. Fredrickson, eds., McGraw Hill, New York, 4th edition, pp. 604–655 (1978).

    Google Scholar 

  12. C. H. Floren, J. J. Albers, B. J. Kudchodkar, and E. L. Bierman J. Biol. Chem. 256: 425 – 433 (1981).

    PubMed  CAS  Google Scholar 

  13. F. Krempler, G. M. Kostner, A. Roscher, F. Haslauer, K. Bolzano and F. Sandhofer, J. Clin. Invest. 71: 1431 – 1441 (1983).

    Article  PubMed  CAS  Google Scholar 

  14. S. H. Gianturco, A. M. Gotto, Jr., S.-L. C. Hwang, J. B. Karlin A. H. Y. Lin, S. C. Prasad, and W. A. Bradley, J. Biol. Chem 258: 4526 – 4533 (1983).

    PubMed  CAS  Google Scholar 

  15. W. A. Bradley, E. B. Gilliam, A. M. Gotto, Jr., and S. H. Gianturco, Biochem. Biophys. Res. Comm. 109: 1360 – 1367 (1982)

    Article  PubMed  CAS  Google Scholar 

  16. S. C. Rall, Jr., K. H. Weisgraber, and R. W. Mahley, J. Biol. Chem. 257: 4171 – 4178 (1982).

    PubMed  CAS  Google Scholar 

  17. C. B. Blum, L. Aron, and R. Sciacca, J. Clin. Invest. 66: 1240 – 1250 (1980).

    Article  PubMed  CAS  Google Scholar 

  18. S. H. Gianturco, A. M. Gotto, Jr., J. B. Karlin, S. C. Prasad, and W. A. Bradley, Fed. Proc. 42: Abstract No. 366 (1983).

    Google Scholar 

  19. G. Schonfeld, W. Patsch, B. Pfleger, J. L. Witztum, and S. W. Weidman, J. Clin. Invest. 65: 1288 – 1297 (1979).

    Article  Google Scholar 

  20. B. J. VanLenten, A. M. Fogelman, M. M. Hokom, L. Benson, M. E. Haberland, and P. A. Edwards, J. Biol. Chem. 258: 5151 – 5157 (1983).

    PubMed  Google Scholar 

  21. P. Lindqvist, A. M. Ostlund-Lindqvist, J. L. Witztum, D. Steinberg, and J. A. Little, J. Biol. Chem. 258: 9086 – 9092 (1983).

    PubMed  CAS  Google Scholar 

  22. S. R. Bates, P. L. Murphey, Z. Feng, T. Kanazawa, and G. S. Getz, Arteriosclerosis Vol. 4, In Press (1984).

    Google Scholar 

  23. W. A. Bradley, D. L. Peavy, J. D. Morrisett, A. M. Gotto, Jr., and S. H. Gianturco, Fed. Proc. 42: Abstract No. 367 (1983).

    Google Scholar 

  24. F. Parker, J. D. Bagdade, G. F. Odland, and E. L. Bierman, J. Clin. Invest. 49: 2172 – 2187 (1970).

    Article  PubMed  CAS  Google Scholar 

  25. K.-S. Hahm, M. J. Tikkanen, R. Darger, T. G. Cole, J. M. Davie, and G. Schonfeld, J. Lipid Res. 24: 877 – 885 (1983).

    PubMed  CAS  Google Scholar 

  26. J. P. Kane, D. A. Hardman, and H. E. Paulus, Proc. Natl. Acad. Sci., U.S.A., 77: 2465 – 2469 (1980).

    Article  PubMed  CAS  Google Scholar 

  27. W. A. Bradley, A. M. Gotto, Jr., D. L. Peavy, and S. H. Gianturco, Circulation 68: 111 – 216 (1983).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Baylor College of Medicine and The Methodist Hospital, 6565 Fannin Street, Houston, Texas, 77030, USA

    S. H. Gianturco, A. M. Gotto Jr. & W. A. Bradley

Authors
  1. S. H. Gianturco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Gotto Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. A. Bradley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. West Chester, Pennsylvania, USA

    William L. Holmes

  3. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Gianturco, S.H., Gotto, A.M., Bradley, W.A. (1985). Hypertriglyceridemia: Lipoprotein Receptors and Atherosclerosis. In: Kritchevsky, D., Holmes, W.L., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism VIII. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2459-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2459-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9493-1

  • Online ISBN: 978-1-4613-2459-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation