Abstract
Reduction of plasma cholesterol and cholesterol-containing lipoproteins, or an increase in high density lipoproteins, is widely accepted as the desired goal for the whole population. It is time that a more critical appraisal is made of this aim in terms of the likely yield and practicability of such a policy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
I. Holme, S. C. Enger, A. Helgeland, I. Hjermann, Paul Leren, P. G. Lund-Larson, L. A. Solberg, and J. P. Strong, Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries, Statistical analysis from the Oslo Study, Arteriosclerosis 1: 250 – 256 (1981).
The Pooling Project Research Group, Relationship of blood pressure serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events, Final report of the Pooling Project, J. Chron. Dis. 31: 201 – 306 (1978).
G. Rose, P. J. S. Hamilton, H. Keen, D. D. Reed, P. McCartney, and R. J. Jarrett, Myocardial ischaemia, risk factors and death from coronary heart disease, Lancet 1: 105 – 109 (1977).
U. Goldbourt and J. H. Medalie, Lipoprotein cholesterol and the incidence of coronary heart disease - the Israeli Ischaemic Heart Disease Study, AMA. J. Epidemiol. 109: 296 – 307 (1975).
L. E. Bottiger and L. A. Carlson, Risk factors for ischaemic vascular death from men in the Stockholm Prospective Study, Atherosclerosis 36: 389 – 408 (1980).
W. P. Castelli, R. D. Abbott, and P. M. McNamara, Summary estimates of cholesterol used to predict coronary heart disease, Circulation 67: 730 – 734 (1983).
F. H. Epstein, in: “Prevention and Treatment of Coronary Heart Disease and its Complications”, Excerpta Medica, Amsterdam, pp. 1–11 (1980).
M. F. Oliver, The optimum serum cholesterol, Lancet 2: 655 (1982).
M. F. Oliver, Should we not forget about mass control of coronary risk factors? Lancet 2: 37 – 38 (1983).
S. Dayton, M. L. Pearce, S. Hashimoto, W. J. Dixon, and U. Tomiyasu, A controlled clinical trial of a diet high in unsaturated fat in preventing complications in atherosclerosis, Circulation 39,40; Suppl. 2: 1 – 63 (1969).
O. Turpeinen, M. J. Karvonen, M. Pekkarinen, M. Miettinen, R. Elosuo, and E. Paavilainen, Dietary prevention of coronary heart disease, The Finnish Mental Hospital Study, Int. J. Epidemiol. 8: 99 – 118 (1979).
Report from the Committee of Principal Investigators, A cooperative trial in the primary prevention of ischaemic heart disease using clofibrate, Brit. Heart J. 10: 1069 – 1118 (1978).
P. Puska, J. Tuomilehto, J. Salonen, L. Neittaaumaki, J. Maki, J. Virtamo, A. Nissinen, K. Koskela, and T. Takalo, Changes in coronary risk factors during comprehensive five-year community programme to control cardiovascular diseases (North Karelia Project), Brit. Med. J. 4: 1173 – 1178 (1979).
J. T. Salonen, P. Puska, and H. Mustaniemi, Changes in morbidity and mortality during comprehensive community programme to control cardiovascular diseases during 1972–77 in North Karelia, Brit. Med. J. 4: 1178 – 1183 (1979).
J. T. Salonen, P. Puska, T. E. Kottke, J. Tuomilehto, A. Nissinen, Decline in mortality from coronary heart disease in Finland from 1969–1979, Brit. Med. J. 286: 1857 – 1860 (1983).
Multiple Risk Factor Intervention Trial, JAMA 248: 1465 – 1468 (1982).
Report of a WHO Expert Committee, Prevention of coronary heart disease, World Health Organisation Technical Report Series 678 (1982)
A. Keys, J. T. Anderson, and F. Grande, Serum cholesterol response to changes in the diet. I. Iodine value of dietary fat versus 2S-P, Metabolism 14:747–758; 766 – 775 (1965).
World Health Organisation, European Collaborative Group, Multifactorial Trial in the Prevention of Coronary Heart Disease. 3. Incidence and Mortality Results, Eur. Heart J. 4: 141 – 147 (1983).
M. Kornitzer, G. DeBacker, M. Dramaix, F. Kittel, C. Thilly, M. Graffar, and K. Vaylsteek, Belgian Heart Disease Prevention Project: Incidence of mortality results, Lancet 1: 1066 – 1070 (1983).
G. Rose, H. D. Tunstall-Pedoe, and R. F. Heller, U. K. Heart Disease Prevention Project: Incidence and mortality results, Lancet 1: 1062 – 1065 (1983).
M. Feinleib and B. M. Rifkind, Changing patterns of cardiovascular disease mortality in the United States, Israel J. Med. Sci. 18: 1098 – 1105 (1982).
L. Wellin, B. Larsson, K. Svardsudd, L. Wilhelmsen, and G. Tibblin, Why is the incidence of ischaemic heart disease in Sweden increasing? Study of men born in 1913 and 1923, Lancet 1: 1087 – 1089 (1983).
L. Alfredsson and A. Ahlbom, Increasing incidence in mortality from myocardial infarction in Stockholm county, Brit. Med. J. 286: 1931 – 1933 (1983).
U. Goldburt and J. D. Kark, Changing patterns of cardiovascular disease mortality in the United States, Israel J. Med. Sci. 18: 1077 – 1097 (1982).
E. Guberan, Surprising decline of cardiovascular mortality in Switzerland, 1951–56, J. Epidemiol. Comm. Health 33: 114 – 120 (1979).
I. Hjermann, I. Holme, K. V. Byre, and P. Leren, The effect of diet and smoking intervention on the incidence of coronary heart disease, Lancet 2: 301 – 310 (1981).
Report of the Committee of Principal Investigators, In preparation.
H. O. Perry, R. K. Winkelmann, R. W. P. Achor, and T. J. Kirby, Side effects of triparanol therapy, Am. J. Med. Sci. 244: 556 – 563 (1962).
A. E. Dorr, K. Gunderson, J. C. Schneider, Jr., T. W. Spencer, and W. B. Martin, Colestipol hydrochloride in hypercholesterolaemic patients - effect on serum cholesterol and mortality, J. Chron. Dis. 31: 5 – 14 (1978).
Lipid Research Clinics Program, The Coronary Primary Prevention Trial: Pesign and Implementation, J. Chron. Dis. 32: 609 – 631 (1979).
M. F. Oliver, Risk of correcting the risk of coronary disease and stroke with drugs, New Engl. J. Med. 306: 297 – 298 (1982).
Medical Research Council Working Party on Mild to Moderate Hypertension, Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension, Lancet 2: 539 – 543 (1981).
P. K. Whelton, P. Brennan, W. E. Miall, G. Greenberg, B. Subramanian, Thiazide associated cardiac arrhythmias, Circulation 66:Suppl. 2 – 238 (1982).
M. F. Oliver, Poctors and the drug industry, Brit. Med. J. 286: 888 – 889 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Oliver, M.F. (1985). Strategy, Yield and Risks of Controlling Plasma Lipids in the Primary Prevention of Coronary Heart Disease. In: Kritchevsky, D., Holmes, W.L., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism VIII. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2459-1_18
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2459-1_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9493-1
Online ISBN: 978-1-4613-2459-1
eBook Packages: Springer Book Archive