Abstract
The replication of DNA requires a balanced supply of the four deoxyribonucleoside triphosphates (dNTPs) that is provided by reduction of the corresponding ribonucleotides through the action of the enzyme ribonucleotide reductase [24]. A single protein catalyzes the reduction of all four ribonucleotides. The evidence for this is two-fold: (i) Homogeneous proteins prepared from bacterial and mammalian sources catalyze the four reactions with about equal efficiency and (ii) single step mutations in the enzyme affect reductions of all ribonucleotides.
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© 1985 Plenum Press, New York
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Reichard, P. (1985). Ribonucleotide Reductase and Deoxyribonucleotide Pools. In: de Serres, F.J. (eds) Genetic Consequences of Nucleotide Pool Imbalance. Basic Life Sciences, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2449-2_3
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DOI: https://doi.org/10.1007/978-1-4613-2449-2_3
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