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Deoxyribonucleoside-Induced Selective Modulation of Cytotoxicity and Mutagenesis

  • Chapter
Genetic Consequences of Nucleotide Pool Imbalance

Part of the book series: Basic Life Sciences ((BLSC,volume 31))

Abstract

Treatment of Chinese hamster cells with deoxythymidine (dThd)‡ and deoxycytidine (dCyd) leads to phosphorylation of these nucleosides and imbalances of the cells’ deoxyribonucleotide (dNTP) pools [17, 36]. Treatment of the cells with alkylating agents leads to alkylation of bases in DNA, and the alkylated bases may mispair during DNA replication [39]. Imbalances of pyrimidine dNTP pools or alkylation of DNA can induce cytotoxicity and mutagenesis [17, 39]. Synergistic effects of alkylating agents and deoxyribonucleosides on mutagenesis and cytotoxicity have been demonstrated by us [30–32] and more recently by other groups [5, 22, 26]. In the present article we have collected the results of our studies in this area. We also report data pertaining to the mechanisms of the above synergistic effects, and we discuss some possible practical applications of our findings to the control of the development of drug resistance in cells treated with chemicals used in cancer chemotherapy.

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Author information

Authors and Affiliations

  1. The Cancer Research Laboratory, University of Southern California Cancer Center, USA

    A. R. Peterson

  2. School of Pharmacy, The Institute for Toxicology, 1303 N. Mission Road, Los Angeles, California, 90033, USA

    A. R. Peterson

  3. Department of Biochemistry, School of Medicine and the Cancer Center University of Southern California, Los Angeles, California, USA

    P. V. Danenberg

Authors
  1. A. R. Peterson
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  2. P. V. Danenberg
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  3. L. L. V. Ibric
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  4. H. Peterson
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Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

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© 1985 Plenum Press, New York

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Peterson, A.R., Danenberg, P.V., Ibric, L.L.V., Peterson, H. (1985). Deoxyribonucleoside-Induced Selective Modulation of Cytotoxicity and Mutagenesis. In: de Serres, F.J. (eds) Genetic Consequences of Nucleotide Pool Imbalance. Basic Life Sciences, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2449-2_19

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  • DOI: https://doi.org/10.1007/978-1-4613-2449-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9488-7

  • Online ISBN: 978-1-4613-2449-2

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