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P1 Plasmid Maintenance: A Paradigm of Precise Control

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Plasmids in Bacteria

Overview

Certain bacterial plasmids, P1 prophage among them, are stably inherited despite their very low copy number (59). In each lysogenic Cell, the mechanisms that guarantee a P1 replication prior to Cell division and an equipartition of the daughter plasmids at Cell division operate with error frequencies comparable to rates of mutation (7,61). In reviewing what we know about how such fidelity is achieved, this article will concentrate on plasmid replication and its control; the accompanying one by Austin and Abeles will consider partitioning.

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Authors and Affiliations

  1. LBI-Basic Research Program NCI-Frederick Cancer Research Facility, Laboratory of Genetics and Recombinant DNA, Frederick, Maryland, 21701, USA

    Dhruba K. Chattoraj, Ann L. Abeles & Michael B. Yarmolinsky

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  1. Dhruba K. Chattoraj
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  2. Ann L. Abeles
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  3. Michael B. Yarmolinsky
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Editors and Affiliations

  1. University of California, San Diego, La Jolla, California, USA

    Donald R. Helinski

  2. Stanford University, Stanford, California, USA

    Stanley N. Cohen

  3. University of Michigan, Ann Harbor, Michigan, USA

    Don B. Clewell

  4. Genex Corporation, Gaithersburg, Maryland, USA

    David A. Jackson

  5. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender

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Chattoraj, D.K., Abeles, A.L., Yarmolinsky, M.B. (1985). P1 Plasmid Maintenance: A Paradigm of Precise Control. In: Helinski, D.R., Cohen, S.N., Clewell, D.B., Jackson, D.A., Hollaender, A. (eds) Plasmids in Bacteria. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2447-8_27

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