Control of Chromosome Replication in Bacteria

  • R. H. Pritchard


The exciting progress that has recently been made in unravelling the replication control mechanisms that determine the copy numbers of several plasmids has been reviewed and updated by several contributors to this volume. In contrast, the control of chromosome replication in bacteria remains largely a closed book.


Chromosome Replication dnaA Strain Exciting Progress Initiation Control oriC Plasmid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yasuda, S., and Y. Hirota (1977) Cloning and mapping of the replication origin of Escherichia coli. Proc. Natl. Acad. Sci., USA 74:5458–5462.PubMedCrossRefGoogle Scholar
  2. 2.
    Yamaguchi, K., M. Yamaguchi, and J. Tomizawa (1982) Incompatibility of plasmids containing the replication origin of the Escherichia coli chromosome. Proc. Natl. Acad. Sci., USA 79:5347–5351.PubMedCrossRefGoogle Scholar
  3. 3.
    von Meyenburg, K., F.G. Hansen, E. Riise, H.E.N. Bergmans, M. Meijer, and W. Messer (1978) Origin of replication, oriC, of the Escherichia coli chromosome: Genetic mapping and minichromosome replication. Cold Spring Harbor Symp. Quant. Biol. 43:121–128.Google Scholar
  4. 4.
    Pritchard, R.H. (1978) Control of DNA replication in bacteria. In DNA Synthesis: Present and Future, I. Molineux and M. Kohijama, eds. Plenum, New York.Google Scholar
  5. 5.
    Pritchard, R.H. (1984) Control of DNA replication in bacteria. In The Microbial Cell Cycle, P. Nurse, and E. Streiblova, eds. CRC Press.Google Scholar
  6. 6.
    Fuller, R.S., and A. Kornberg (1983) Purified dnaA protein in initiation of replication at the Escherichia coli chromosomal origin of replication. Proc. Natl. Acad. Sci., USA. 80:5817–5821.PubMedCrossRefGoogle Scholar
  7. 7.
    Churchward, G., P. Holmans, and H. Bremer (1983) Increased expression of the dnaA gene has no effect on DNA replication in a dnaA strain of Escherichia coli. Mol. Gen. Genet. 192:506–508.PubMedCrossRefGoogle Scholar
  8. 8.
    Orr, E., P.A. Meacock, and R.H. Pritchard (1978) Genetic and physiological properties of an Escherichia coli strain carrying the dnaA gene mutation T46. In DNA Synthesis: Present and Future, I. Molineaux, and M. Kohimaja, eds. Plenum, New York.Google Scholar
  9. 9.
    Hansen, F.G. and K.V. Rasmussen (1977) Regulation of the dnaA product in Escherichia coli. Mol. Gen. Genet. 155:219–225.PubMedCrossRefGoogle Scholar
  10. 10.
    Lycett, G.W., E. Orr, and R.H. Pritchard (1980) Chloramphenicol releases the block in initiation of chromosome replication in a dnaA strain of Escherichia coli K12. Mil. Gen. Genet. 178:329–336.CrossRefGoogle Scholar
  11. 11.
    Shen, V., and H. Bremer (1977) Chloramphenicol induces changes in the synthesis of ribosomal transfer and messenger ribonucleic acids in Escherichia coliB/r. J. Bact. 130:1098–1108.PubMedGoogle Scholar
  12. 12.
    Choung, K.K., E. Estiva, and H. Bremer (1981) Genetic and physiological characterization of a spontaneous mutant of Escherichia coliB/r with aberrant control of deoxyribonucleic acid replication. J. Bact. 145:1239–1246.PubMedGoogle Scholar
  13. 13.
    Rasmussen, K.V., T. Atlung, G. Kersman, G.E. Hansen, and F.G. Hansen (1983) Conditional change of DNA replication control in an RNA polymerase mutant of Escherichia coli. J. Bact. 1564:443–451.Google Scholar
  14. 14.
    Tanaka, M., H. Ohmori, and S. Hiraga (1983) A novel type of E. coli mutants with increased chromosomal copy number. Mol. Gen. Genet. 192:51–60.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • R. H. Pritchard
    • 1
  1. 1.Department of GeneticsThe University of LeicesterLeicesterEngland

Personalised recommendations