Abstract
In ancient Rome mean human lifespan was about 22 years whereas nowadays in USA it is about 74 years. Although this dramatic difference actually reflects a substantial improvement in general health care measures it also brought about a huge and increasing concern on the so-called “diseases of aging”, namely cardiovascular diseases and cancer as these two conditions represent the leading causes of death and disability in developed countries as well as the major challenges facing medical research.
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The hypotheses and analogies in themselves have no value in scientific investigation except to the extent that they function as entering wedges for further investigation.
R. VIRCHOW
(“Standpoints in scientific medicine”1847)
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References
E.P. BENDITT and J.M. BENDITT. “Evidence for monoclonal origin of human atherosclerotic plaques”. Proc. Natl. Acad. Sci. USA. 70; 1753, 1973
.A. PEARSON, A, WANG, K. SOLEZ and R.H. HEPTINSTALL. “Clonal characteristics of fibrous plaques and fatty streaks from human aortas”, Am. J. Pathol. 81:379, 1975.
R.E. ALBERT, M. VANDERLAAN, F.J. BURNS and M. NISHIZUMI. “Effect of carcinogens on chicken atherosclerosis”. Cancer Res. 37: 2232, 1977.
H.P. SHU and A.V. NICHOLS. “Benzo (a) pyrene uptake by human plasma lipoproteins in vitro”. Cancer Res. 39: 1224, 1979.
B.N. AMES, J. McCANN and E. YAMASAKI. “Mthods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome test”. Mutation Res. 31: 347, 1975.
F.W. ROBERTSON, A.M. CUMMING, A.S. DOUGLAS, E.B. SMITH and A.C.F. KENMURE. “Coronary heart disease in North-East Scotland. A study of genetic and environmental variations in serum lipoproteins and other variables”. Scott. Med. J. 25; 212, 1980.
K.G. TAYLOR, T.J. CARTER, A.J. VALENTE, A.D. WRIGHT, J.H. SMITH and K.A. MATHEWS. “Sex differences in the relationships between obesity, alcohol consumption and cigarett/smoking and serum lipid and apolipoprotein concentrations in a normal population”. Atherosclerosis, 38: 11, 1981.
J.F. REMSEN and R.B. SHI REMAN. “Effect of low-density lipoprotein on the incorporation of benzo (a) pyrene by cultured cells”. Cancer Res. 41: 3179, 1981.
P. KQTIN, H.L. FALK and BUSSER. “Distribution, retention and elimination of 1 4C-3, 4-benzpyrene after administration to mice and rats”. J. Natl. Cancer.Inst. 23:541, 1959.
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© 1985 Plenum Press, New York
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Rueff, J., Halpern, M.J. (1985). Testing Human lipoproteins for Mutagenic Activity in the Salmonella/Microsome Assay. In: Halpern, M.J. (eds) Lipid Metabolism and Its Pathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2445-4_20
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DOI: https://doi.org/10.1007/978-1-4613-2445-4_20
Publisher Name: Springer, Boston, MA
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