Abstract
Lipid composition was compared in liver and brain from genetically obese (ob/ob), heterozygote (ob/+) and normal (+/+) mice. In liver, but not in brain, a constitution favoring a “rigidification” of the membranes was found in (ob/ob) mice. In both organs a decrease of the total ganglioside sfalic acid concentration was observed. These results could be related to the reduced number of insulin receptors in (ob/ob) mice hepatocytes and to a different behaviour of their brain receptors. In addition, they suggest that an abnormal complex carbohydrate metabolism involving gangliosides may exist in this syndrome.
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© 1985 Plenum Press, New York
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Sena, A., Rebel, G., Bieth, R., Waksman, A. (1985). Contribution to the Study of the Lipid Constitution in Liver and Brain Homogenates of Mice Genetically Obese. In: Halpern, M.J. (eds) Lipid Metabolism and Its Pathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2445-4_14
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DOI: https://doi.org/10.1007/978-1-4613-2445-4_14
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