Dietary Regulation of Rat Serum Lipids and Lipoproteins
Effects of dietary manipulation on serum lipids and lipoproteins in rats of different age are reported:
Serum lipids (triglycerides, cholesterol and phospholipids) decreased on starvation. The decrease was more intense in young than in old individuals. In contrast, serum proteins decreased only in old animals.
Refeeding a balanced or a high-sucrose, fat-free diet increased serum lipids. Triglyceride changes followed oscillatory kinetics, while cholesterol and phospholipids exhibited an overshoot phenomenon. Cholesteron and phospholipids, after stravation responded to refeeding only with a 24h retardation, instead they continued to decline after initiation of refeeding. Refeeding a balanced diet produced marked differences of the serum lipid changes between young and old animals, while the changes were very similar in the two series of rats on refeeding a fat-free diet.
Serum lipid variations on starvation and refeeding were reflected in the lipoprotein profiles. Triglyceride changes in the chylomicron-and VLDL fractions followed precisely the oscillatory kinetics, cholesterol and phospholipid variations in the LDL and HDL fractions were exactly those of total serum. In addition, VLDL cholesterol and phospholipid strongly decreased during starvation and increased immediately after initiation of the refeeding period.
KeywordsSerum Lipid Lipoprotein Fraction Dietary Regulation Serum Phospholipid VLDL Cholesterol
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