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Interaction Between Blood Components and Hydrogels With Poly(Oxyethylene) Chains

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Abstract

When a biologically imcompatible material is in contact with blood, there takes place thrombus formation on it via a rapid adsorption of plasma proteins and the subsequent adhesion of platelets. Numerous approaches to supress the adhesion of blood components onto synthetic surfaces have been studied and hydrogels are found to be useful.

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References

  1. A. Abuchowski, T. van Es, N. C. Palczuk, and F. F. Davis, Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol, J. Biol. Chem., 252:3578 (1977).

    CAS  Google Scholar 

  2. S. Nagaoka, M. Shiota, Y. Mori, and T. Kikuchi, Kinetics of photo-induced graft copolymerization to poly(vinyl chloride) containing diethyldithiocarbamate groups, Kobunshi Ronbunshu, 38:571 (1981).

    Article  CAS  Google Scholar 

  3. K. Yokota, A. Abe, S. Hosaka, Y. Sakai, and H. Saito, A 13C nuclear magnetic resonance study of covalently cross-linked gels. Effect of chemical composition, degree of cross-linking, and temperature to chain mobility, Macromolecules, 11:95 (1978).

    Article  CAS  Google Scholar 

  4. F. Th. Hesslink, A Vrij, and J. Th. Overbeek, On the theory of the stabilization of dispersions by adsorbed macromolecules. II. Interaction between two flat particles, J. Phys. Chem., 75:2094 (1971).

    Article  Google Scholar 

  5. D. J. Meier, Theory of polymeric dispersants. Statistics of constrained polymer chains, J. Phys. Chem., 71:1861 (1967).

    Article  CAS  Google Scholar 

  6. N. G. Maroudas, Polymer exclusion, cell adhesion and membrane fusion, Nature, 254:695 (1975).

    Article  CAS  Google Scholar 

  7. Y. Noishiki, An in vivo test for evaluation of blood compatibility by insertion of the polymer coated suture into the peripheral vein, Jpn. J. Artif. Organs, 11:794 (1982).

    Google Scholar 

  8. Y. Mori, S. Nagaoka, H. Takiuchi, T. Kikuchi, N. Noguchi, H. Tanzawa, and Y. Noishiki, A new antithrombogenic material with long polyethyleneoxide chains, Trans. Am. Soc. Artif. Intern. Organs, 28:459 (1982).

    CAS  Google Scholar 

  9. Y. Mori, S. Nagaoka, H. Takiuchi, T. Kikuchi, N. Noguchi, H. Tanzawa, and Y. Noishiki, A new antithrombogenic material with long polyethyleneoxide chains, Trans. Am. Soc. Artif. Intern. Organs, 28:459 (1982).

    CAS  Google Scholar 

  10. Dr. D. Regoli and V. Clark, Prevention by adenosine of the effect of adenosine diphosphate on the concentration of circulating platelets, Nature, 200:546 (1963).

    Article  CAS  Google Scholar 

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© 1984 Plenum Press, New York

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Nagaoka, S., Mori, Y., Takiuchi, H., Yokota, K., Tanzawa, H., Nishiumi, S. (1984). Interaction Between Blood Components and Hydrogels With Poly(Oxyethylene) Chains. In: Shalaby, S.W., Hoffman, A.S., Ratner, B.D., Horbett, T.A. (eds) Polymers as Biomaterials. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2433-1_26

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  • DOI: https://doi.org/10.1007/978-1-4613-2433-1_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9480-1

  • Online ISBN: 978-1-4613-2433-1

  • eBook Packages: Springer Book Archive

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