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Influence of Gel and Solute Structure on In Vitro and In Vivo Release Kinetics From Hydrogels

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Polymers as Biomaterials

Abstract

Drug release kinetics from polymer implants in vivo are influenced by the rate of drug diffusion within the polymer, and by the nature of the medium surrounding the implant. Our previous work has investigated the influence of gel structure on the diffusion characteristics of solutes through poly(2-hydroxyethyl methacrylate) (polyHEMA) hydrogels (1). The diffusion mechanism was found to be influenced by the nature of the water within the gel, and the average pore size of the network. Sorption of solutes was reported to have a marked effect on network structure (2).

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Author information

Authors and Affiliations

  1. Department of Pharmacy, University of Manchester, Manchester, M13 9PL, UK

    J. M. Wood, D. Attwood & J. H. Collett

Authors
  1. J. M. Wood
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  2. D. Attwood
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  3. J. H. Collett
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Editor information

Editors and Affiliations

  1. ETHICON, Inc., A Johnson & Johnson Company, Somerville, New Jersey, USA

    Shalaby W. Shalaby

  2. University of Washington, Seattle, Washington, USA

    Allan S. Hoffman , Buddy D. Ratner  & Thomas A. Horbett ,  & 

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© 1984 Plenum Press, New York

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Wood, J.M., Attwood, D., Collett, J.H. (1984). Influence of Gel and Solute Structure on In Vitro and In Vivo Release Kinetics From Hydrogels. In: Shalaby, S.W., Hoffman, A.S., Ratner, B.D., Horbett, T.A. (eds) Polymers as Biomaterials. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2433-1_25

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  • DOI: https://doi.org/10.1007/978-1-4613-2433-1_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9480-1

  • Online ISBN: 978-1-4613-2433-1

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